ZFIN Lab: Wingert Lab

ZFIN ID: ZDB-LAB-110801-1

Wingert Lab

PI/Director:	Wingert, Rebecca
Contact Person:	Wingert, Rebecca
Email:	rwingert@nd.edu
URL:
Address:	University of Notre Dame Department of Biological Sciences 100 Galvin Life Sciences Building Notre Dame IN 46556 USA
Country:	United States
Phone:	(574) 631-0907
Fax:	(574) 631-7413
Line Designation:	nt

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 2 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Chambers, Brooke Graduate Student	Chambers, Joseph Graduate Student	Cheng, Christina Graduate Student
Drummond, Bridgette Graduate Student	Love, Janice Graduate Student	Marra, Amanda Graduate Student
Morales, Elvin Graduate Student	Poureetezadi, Shahram Graduate Student	White, Audra Graduate Student
Chen, Karen	Handa, Nicole	Levesque, Anna
Springer, Meghan	Ulrich, Marisa

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Wesselman, H.M., Flores-Mireles, A.L., Bauer, A., Pei, L., Wingert, R.A. (2023) Esrrγa regulates nephron and ciliary development by controlling prostaglandin synthesis. Development (Cambridge, England). 150(10):

Nguyen, T.K., Petrikas, M., Chambers, B.E., Wingert, R.A. (2023) Principles of Zebrafish Nephron Segment Development. Journal of developmental biology. 11(1):

Wesselman, H.M., Gatz, A.E., Pfaff, M.R., Arceri, L., Wingert, R.A. (2023) Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney. Cells. 12(4):

Weaver, N.E., Healy, A., Wingert, R.A. (2022) gldc Is Essential for Renal Progenitor Patterning during Kidney Development. Biomedicines. 10(12):

Drummond, B.E., Chambers, B.E., Wesselman, H.M., Gibson, S., Arceri, L., Ulrich, M.N., Gerlach, G.F., Kroeger, P.T., Leshchiner, I., Goessling, W., Wingert, R.A. (2022) osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2. Biomedicines. 10(11):

Demery-Poulos, C., Chambers, J.M. (2022) Identification, conservation, and expression of tiered pharmacogenes in zebrafish. PLoS One. 17:e0273582

Chambers, J.M., Addiego, A., Flores-Mireles, A.L., Wingert, R.A. (2020) Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis. Cell Reports. 33:108370

Chambers, B.E., Clark, E.G., Gatz, A.E., Wingert, R.A. (2020) Kctd15 regulates nephron segment development by repressing Tfap2a activity. Development (Cambridge, England). 147(23):

Chambers, B.E., Wingert, R.A. (2019) A zebrafish tale of parabiosis, podocytes, and proteinuria. Kidney International. 96:272-275

Chambers, B.E., Wingert, R.A. (2019) Mechanisms of Nephrogenesis Revealed by Zebrafish Chemical Screen: Prostaglandin Signaling Modulates Nephron Progenitor Fate. Nephron. 143(1):68-76

Chambers, B.E., Gerlach, G.F., Clark, E.G., Chen, K.H., Levesque, A.E., Leshchiner, I., Goessling, W., Wingert, R.A. (2019) Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Development (Cambridge, England). 146(13):

Marra, A.N., Cheng, C.N., Adeeb, B., Addiego, A., Wesselman, H.M., Chambers, B.E., Chambers, J.M., Wingert, R.A. (2019) Iroquois transcription factor irx2a is required for multiciliated and transporter cell fate decisions during zebrafish pronephros development. Scientific Reports. 9:6454

Marra, A.N., Adeeb, B.D., Chambers, B.E., Drummond, B.E., Ulrich, M., Addiego, A., Springer, M., Poureetezadi, S.J., Chambers, J.M., Ronshaugen, M., Wingert, R.A. (2019) Prostaglandin signaling regulates renal multiciliated cell specification and maturation. Proceedings of the National Academy of Sciences of the United States of America. 116(17):8409-8418

Marra, A.N., Chambers, B.E., Chambers, J.M., Drummond, B.E., Adeeb, B.D., Wesselman, H.M., Morales, E.E., Handa, N., Pettini, T., Ronshaugen, M., Wingert, R.A. (2019) Visualizing gene expression during zebrafish pronephros development and regeneration. Methods in cell biology. 154:183-215

Morales, E.E., Handa, N., Drummond, B.E., Chambers, J.M., Marra, A.N., Addiego, A., Wingert, R.A. (2018) Homeogene emx1 is required for nephron distal segment development in zebrafish. Scientific Reports. 8:18038

Chambers, J.M., Poureetezadi, S.J., Addiego, A., Lahne, M., Wingert, R.A. (2018) ppargc1a controls nephron segmentation during zebrafish embryonic kidney ontogeny. eLIFE. 7:

Drummond, B.E., Wingert, R.A. (2018) Scaling up to study brca2: the zeppelin zebrafish mutant reveals a role for brca2 in embryonic development of kidney mesoderm.. Cancer cell & microenvironment. 5(1)

Marra, A.N., Ulrich, M., White, A., Springer, M., Wingert, R.A. (2017) Visualizing Multiciliated Cells in the Zebrafish Through a Combined Protocol of Whole Mount Fluorescent In Situ Hybridization and Immunofluorescence. Journal of visualized experiments : JoVE. (129)

Kroeger, P.T., Drummond, B.E., Miceli, R., McKernan, M., Gerlach, G.F., Marra, A.N., Fox, A., McCampbell, K.K., Leshchiner, I., Rodriguez-Mari, A., BreMiller, R., Thummel, R., Davidson, A.J., Postlethwait, J., Goessling, W., Wingert, R.A. (2017) The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Developmental Biology. 428(1):148-163

Drummond, B.E., Li, Y., Marra, A.N., Cheng, C.N., Wingert, R.A. (2017) The tbx2a/b transcription factors direct pronephros segmentation and corpuscle of Stannius formation in zebrafish. Developmental Biology. 421(1):52-66

Morales, E.E., Wingert, R.A. (2017) Zebrafish as a Model of Kidney Disease. Results and problems in cell differentiation. 60:55-75

Poureetezadi, S.J., Cheng, C.N., Chambers, J.M., Drummond, B.E., Wingert, R.A. (2016) Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development. eLIFE. 5

Chambers, B.E., Wingert, R.A. (2016) Renal progenitors: Roles in kidney disease and regeneration. World journal of stem cells. 8:367-375

Marra, A.N., Li, Y., Wingert, R.A. (2016) Antennas of organ morphogenesis: The roles of cilia in vertebrate kidney development. Genesis (New York, N.Y. : 2000). 54(9):457-69

McKee, R.A., Wingert, R.A. (2016) Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury. Journal of visualized experiments : JoVE. (113)

Poureetezadi, S.J., Wingert, R.A. (2016) Little fish, big catch: zebrafish as a model for kidney disease. Kidney International. 89(6):1204-10

Marra, A.N., Wingert, R.A. (2016) Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development. Developmental Biology. 411(2):231-45

Drummond, B.E., Wingert, R.A. (2016) Insights into kidney stem cell development and regeneration using zebrafish. World journal of stem cells. 8:22-31

Gerlach, G.F., Morales, E.E., Wingert, R.A. (2015) Microbead Implantation in the Zebrafish Embryo. Journal of visualized experiments : JoVE. (101):e52943

Cheng, C.N., Verdun, V.A., Wingert, R.A. (2015) Recent Advances in Elucidating the Genetic Mechanisms of Nephrogenesis Using Zebrafish. Cells. 4:218-233

Cheng, C.N., Wingert, R.A. (2015) Nephron proximal tubule patterning and corpuscles of Stannius formation are regulated by the sim1a transcription factor and retinoic acid in zebrafish. Developmental Biology. 399(1):100-16

McCampbell, K.K., Springer, K.N., Wingert, R.A. (2015) Atlas of Cellular Dynamics during Zebrafish Adult Kidney Regeneration. Stem Cells International. 2015:547636

McKee, R.A., Wingert, R.A. (2015) Zebrafish Renal Pathology: Emerging Models of Acute Kidney Injury. Current pathobiology reports. 3:171-181

Gerlach, G.F., Wingert, R.A. (2014) Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta. Developmental Biology. 396(2):183-200

Poureetezadi, S.J., Donahue, E.K., Wingert, R.A. (2014) A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos. Journal of visualized experiments : JoVE. (93):e52063

McKee, R., Gerlach, G.F., Jou, J., Cheng, C.N., Wingert, R.A. (2014) Temporal and spatial expression of tight junction genes during zebrafish pronephros development. Gene expression patterns : GEP. 16:104-113

Morales, E.E., Wingert, R.A. (2014) Renal stem cell reprogramming: Prospects in regenerative medicine. World journal of stem cells. 6:458-66

Kroeger, P.T., Wingert, R.A. (2014) Using Zebrafish to Study Podocyte Genesis During Kidney Development and Regeneration. Genesis (New York, N.Y. : 2000). 52(9):771-92

McCampbell, K.K., Springer, K.N., Wingert, R.A. (2014) Analysis of nephron composition and function in the adult zebrafish kidney. Journal of visualized experiments : JoVE. (90):e51644

Cheng, C.N., Li, Y., Marra, A.N., Verdun, V., Wingert, R.A. (2014) Flat Mount Preparation for Observation and Analysis of Zebrafish Embryo Specimens Stained by Whole Mount In situ Hybridization. Journal of visualized experiments : JoVE. (89)

Kroeger, P.T., Poureetezadi, S.J., McKee, R., Jou, J., Miceli, R., Wingert, R.A. (2014) Production of Haploid Zebrafish Embryos by In Vitro Fertilization. Journal of visualized experiments : JoVE. (89)

Li, Y., Cheng, C.N., Verdun, V.A., and Wingert, R.A. (2014) Zebrafish nephrogenesis is regulated by interactions between retinoic acid, mecom, and Notch signaling. Developmental Biology. 386(1):111-122

McCampbell, K.K., and Wingert, R.A. (2014) New tides: using zebrafish to study renal regeneration. Translational research : the journal of laboratory and clinical medicine. 163(2):109-122

Marra, A.N., Wingert, R.A. (2014) Roles of Iroquois Transcription Factors in Kidney Development. Cell & developmental biology. 3(1):1000131

Miceli, R., Kroeger, P., Wingert, R. (2014) Molecular Mechanisms of Podocyte Development Revealed by Zebrafish Kidney Research. Cell & developmental biology. 3:353-7

Gerlach, G.F., and Wingert, R.A. (2013) Kidney organogenesis in the zebrafish: insights into vertebrate nephrogenesis and regeneration. Wiley Interdisciplinary Reviews: Developmental Biology. 2(5):559-585

Poureetezadi, S.J., Wingert, R.A. (2013) Congenital and Acute Kidney Disease: Translational Research Insights from Zebrafish Chemical Genetics. General medicine (Los Angeles, Calif.). 1:112

O'Brien, L.L., Grimaldi, M., Kostun, Z., Wingert, R.A., Selleck, R., and Davidson, A.J. (2011) Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish. Developmental Biology. 358(2):318-30

Gerlach, G.F., Schrader, L.N., and Wingert, R.A. (2011) Dissection of the adult zebrafish kidney. Journal of visualized experiments : JoVE. (54)

Johnson, C.S., Holzemer, N.F., and Wingert, R.A. (2011) Laser ablation of the zebrafish pronephros to study renal epithelial regeneration. Journal of visualized experiments : JoVE. (54)

Wingert, R.A., and Davidson, A.J. (2011) Zebrafish nephrogenesis involves dynamic spatiotemporal expression changes in renal progenitors and essential signals from retinoic acid and irx3b. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(8):2011-2027

Lengerke, C., Wingert, R., Beeretz, M., Grauer, M., Schmidt, A.G., Konantz, M., Daley, G.Q., and Davidson, A.J. (2011) Interactions between Cdx genes and retinoic acid modulate early cardiogenesis. Developmental Biology. 354(1):134-142

Diep, C.Q., Ma, D., Deo, R.C., Holm, T.M., Naylor, R.W., Arora, N., Wingert, R.A., Bollig, F., Djordjevic, G., Lichman, B., Zhu, H., Ikenaga, T., Ono, F., Englert, C., Cowan, C.A., Hukriede, N.A., Handin, R.I., and Davidson, A.J. (2011) Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 470(7332):95-100

Fraenkel, P.G., Gibert, Y., Holzheimer, J.L., Lattanzi, V.J., Burnett, S.F., Dooley, K.A., Wingert, R.A., and Zon, L.I. (2009) Transferrin-a modulates hepcidin expression in zebrafish embryos. Blood. 113(12):2843-2850

Dooley, K.A., Fraenkel, P.G., Langer, N.B., Schmid, B., Davidson, A.J., Weber, G., Chiang, K., Foott, H., Dwyer, C., Wingert, R.A., Zhou, Y., Paw, B.H., Zon, L.I., and Tübingen 2000 Screen Consortium . (2008) montalcino, A zebrafish model for variegate porphyria. Experimental hematology. 36(9):1132-1142

Wingert, R.A., and Davidson, A.J. (2008) The zebrafish pronephros: A model to study nephron segmentation. Kidney International. 73(10):1120-1127

Galloway, J.L., Wingert, R.A., Thisse, C., Thisse, B., and Zon, L.I. (2008) Combinatorial regulation of novel erythroid gene expression in zebrafish. Experimental hematology. 36(4):424-432

Wingert, R.A., Selleck, R., Yu, J., Song, H.D., Chen, Z., Song, A., Zhou, Y., Thisse, B., Thisse, C., McMahon, A.P., and Davidson, A.J. (2007) The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros. PLoS Genetics. 3(10):1922-1938

Shaw, G.C., Cope, J.J., Li, L., Corson, K., Hersey, C., Ackermann, G.E., Gwynn, B., Lambert, A.J., Wingert, R.A., Traver, D., Trede, N.S., Barut, B.A., Zhou, Y., Minet, E., Donovan, A., Brownlie, A., Balzan, R., Weiss, M.J., Peters, L.L., Kaplan, J., Zon, L.I., and Paw, B.H. (2006) Mitoferrin is essential for erythroid iron assimilation. Nature. 440(7080):96-100

Wingert, R.A., Zon, L.I., Godin, I. (ed) and Cumano, A. (ed) (2006) Genetic Dissection of Hematopoiesis Using the Zebrafish. Hematopoietic Stem Cell Development. 2:12p

Wingert, R.A., Galloway, J.L., Barut, B., Foott, H., Fraenkel, P., Axe, J.L., Weber, G.J., Dooley, K., Davidson, A.J., Schmid, B., Paw, B.H., Shaw, G.C., Kingsley, P., Palis, J., Schubert, H., Chen, O., Kaplan, J., Zon, L.I., Tübingen 2000 Screen Consortium. (2005) Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature. 436(7053):1035-1039

Galloway, J.L., Wingert, R.A., Thisse, C., Thisse, B., and Zon, L.I. (2005) Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Developmental Cell. 8(1):109-116

Wingert, R.A. (2005) Genetic analysis of vertebrate hemoglobin synthesis : characterization of the zebrafish hypochromic mutants chianti and shiraz. Ph.D. Thesis. :143p

Wingert, R.A., Brownlie, A., Galloway, J.L., Dooley, K., Fraenkel, P., Axe, J.L., Davidson, A.J., Barut, B., Noriega, L., Sheng, X., Zhou, Y., Tübingen 2000 Screen Consortium, and Zon, L.I. (2004) The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1. Development (Cambridge, England). 131(24):6225-6235