ZFIN Lab: Guillemin Lab

ZFIN ID: ZDB-LAB-050228-1

Guillemin Lab

PI/Director:	Guillemin, Karen
Contact Person:	Guillemin, Karen
Email:	guillemin@molbio.uoregon.edu
URL:
Address:	Institute of Molecular Biology 1229 University of Oregon Eugene, OR 97403-1229 USA
Country:	United States
Phone:	(541) 346-5999
Fax:	(541) 346-5891
Line Designation:	b

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 13 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Cheesman, Sarah Post-Doc	Milligan-Myhre, Kathy Post-Doc	Bates, Jennifer M. Graduate Student
Mittge, Erika K. Research Staff	Neal, J. T.

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Smith, T.J., Sundarraman, D., Melancon, E., Desban, L., Parthasarathy, R., Guillemin, K. (2023) A mucin-regulated adhesin determines the spatial organization and inflammatory character of a bacterial symbiont in the vertebrate gut. Cell Host & Microbe. 31(8):1371-1385.e6

Massaquoi, M.S., Kong, G.L., Chilin-Fuentes, D., Ngo, J.S., Horve, P.F., Melancon, E., Hamilton, M.K., Eisen, J.S., Guillemin, K. (2023) Cell-type-specific responses to the microbiota across all tissues of the larval zebrafish. Cell Reports. 42:112095112095

Banse, A.V., VanBeuge, S., Smith, T.J., Logan, S.L., Guillemin, K. (2023) Secreted Aeromonas GlcNAc binding protein GbpA stimulates epithelial cell proliferation in the zebrafish intestine. Gut microbes. 15:21836862183686

Bruckner, J.J., Stednitz, S.J., Grice, M.Z., Zaidan, D., Massaquoi, M.S., Larsch, J., Tallafuss, A., Guillemin, K., Washbourne, P., Eisen, J.S. (2022) The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons. PLoS Biology. 20:e3001838

Hill, J.H., Massaquoi, M.S., Sweeney, E.G., Wall, E.S., Jahl, P., Bell, R., Kallio, K., Derrick, D., Murtaugh, L.C., Parthasarathy, R., Remington, S.J., Round, J.L., Guillemin, K. (2022) BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass. Cell Metabolism. 34(11):1779-1791.e9

Sundarraman, D., Smith, T.J., Kast, J.V.Z., Guillemin, K., Parthasarathy, R. (2022) Disaggregation as an interaction mechanism among intestinal bacteria. Biophysical journal. 121(18):3458-3473

Jawahar, J., McCumber, A.W., Lickwar, C.R., Amoroso, C.R., de la Torre Canny, S.G., Wong, S., Morash, M., Thierer, J.H., Farber, S.A., Bohannan, B.J.M., Guillemin, K., Rawls, J.F. (2022) Starvation causes changes in the intestinal transcriptome and microbiome that are reversed upon refeeding. BMC Genomics. 23:225

Hamilton, M.K., Wall, E.S., Robinson, C.D., Guillemin, K., Eisen, J.S. (2022) Enteric nervous system modulation of luminal pH modifies the microbial environment to promote intestinal health. PLoS pathogens. 18:e1009989

Robinson, C.D., Sweeney, E.G., Ngo, J., Ma, E., Perkins, A., Smith, T.J., Fernandez, N.L., Waters, C.M., Remington, S.J., Bohannan, B.J.M., Guillemin, K. (2021) Host-emitted amino acid cues regulate bacterial chemokinesis to enhance colonization. Cell Host & Microbe. 29(8):1221-1234.e8

Hinman, M.N., Richardson, J.I., Sockol, R.A., Aronson, E.D., Stednitz, S.J., Murray, K.N., Berglund, J.A., Guillemin, K. (2021) Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy. Disease models & mechanisms. 14(6):

Kent, M.L., Wall, E.S., Sichel, S., Watral, V., Stagaman, K., Sharpton, T.J., Guillemin, K. (2021) Pseudocapillaria tomentosa, Mycoplasma spp., and Intestinal Lesions in Experimentally Infected Zebrafish Danio rerio. Zebrafish. 18(3):207-220

Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):

Loes, A.N., Hinman, M.N., Farnsworth, D.R., Miller, A.C., Guillemin, K., Harms, M.J. (2021) Identification and Characterization of Zebrafish Tlr4 Coreceptor Md-2. Journal of immunology (Baltimore, Md. : 1950). 206(5):1046-1057

Solis, C.J., Hamilton, M.K., Caruffo, M., Garcia-Lopez, J.P., Navarrete, P., Guillemin, K., Feijoo, C.G. (2020) Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish. Frontiers in immunology. 11:1330

Stagaman, K., Sharpton, T.J., Guillemin, K. (2020) Zebrafish microbiome studies make waves. Lab animal. 49(7):201-207

Wiles, T.J., Schlomann, B.H., Wall, E.S., Betancourt, R., Parthasarathy, R., Guillemin, K. (2020) Swimming motility of a gut bacterial symbiont promotes resistance to intestinal expulsion and enhances inflammation. PLoS Biology. 18:e3000661

Schlomann, B.H., Wiles, T.J., Wall, E.S., Guillemin, K., Parthasarathy, R. (2019) Sublethal antibiotics collapse gut bacterial populations by enhancing aggregation and expulsion. Proceedings of the National Academy of Sciences of the United States of America. 116(43):21392-21400

Chia, J.S.M., Wall, E.S., Wee, C.L., Rowland, T.A.J., Cheng, R.K., Cheow, K., Guillemin, K., Jesuthasan, S. (2019) Bacteria evoke alarm behaviour in zebrafish. Nature communications. 10:3831

Wiles, T.J., Guillemin, K. (2019) The Other Side of the Coin: What Beneficial Microbes Can Teach us about Pathogenic Potential. Journal of molecular biology. 431(16):2946-2956

Robinson, C.D., Klein, H.S., Murphy, K.D., Parthasarathy, R., Guillemin, K., Bohannan, B.J.M. (2018) Experimental bacterial adaptation to the zebrafish gut reveals a primary role for immigration. PLoS Biology. 16:e2006893

Rolig, A.S., Sweeney, E.G., Kaye, L.E., DeSantis, M.D., Perkins, A., Banse, A.V., Hamilton, M.K., Guillemin, K. (2018) A bacterial immunomodulatory protein with lipocalin-like domains facilitates host-bacteria mutualism in larval zebrafish. eLIFE. 7:

Schlomann, B.H., Wiles, T.J., Wall, E.S., Guillemin, K., Parthasarathy, R. (2018) Bacterial Cohesion Predicts Spatial Distribution in the Larval Zebrafish Intestine. Biophysical journal. 115(11):2271-2277

Wiles, T.J., Wall, E.S., Schlomann, B.H., Hay, E.A., Parthasarathy, R., Guillemin, K. (2018) Modernized Tools for Streamlined Genetic Manipulation and Comparative Study of Wild and Diverse Proteobacterial Lineages. mBio. 9(5)

Troll, J.V., Hamilton, M.K., Abel, M.L., Ganz, J., Bates, J.M., Stephens, W.Z., Melancon, E., van der Vaart, M., Meijer, A.H., Distel, M., Eisen, J.S., Guillemin, K. (2018) Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling. Development (Cambridge, England). 145(4)

Burns, A.R., Miller, E., Agarwal, M., Rolig, A.S., Milligan-Myhre, K., Seredick, S., Guillemin, K., Bohannan, B.J.M. (2017) Interhost dispersal alters microbiome assembly and can overwhelm host innate immunity in an experimental zebrafish model. Proceedings of the National Academy of Sciences of the United States of America. 114(42):11181-11186

Burns, A.R., Watral, V., Sichel, S., Spagnoli, S., Banse, A.V., Mittge, E., Sharpton, T.J., Guillemin, K., Kent, M.L. (2017) Transmission of a common intestinal neoplasm in zebrafish by cohabitation. Journal of fish diseases. 41(4):569-579

Stagaman, K., Burns, A.R., Guillemin, K., Bohannan, B.J. (2017) The role of adaptive immunity as an ecological filter on the gut microbiota in zebrafish. The ISME Journal. 11:1630-1639

Burns, A.R., Guillemin, K. (2017) The scales of the zebrafish: host-microbiota interactions from proteins to populations. Current opinion in microbiology. 38:137-141

Rolig, A.S., Mittge, E.K., Ganz, J., Troll, J.V., Melancon, E., Wiles, T.J., Alligood, K., Stephens, W.Z., Eisen, J.S., Guillemin, K. (2017) The enteric nervous system promotes intestinal health by constraining microbiota composition. PLoS Biology. 15:e2000689

Melancon, E., Gomez De La Torre Canny, S., Sichel, S., Kelly, M., Wiles, T.J., Rawls, J.F., Eisen, J.S., Guillemin, K. (2017) Best practices for germ-free derivation and gnotobiotic zebrafish husbandry. Methods in cell biology. 138:61-100

Hill, J.H., Franzosa, E.A., Huttenhower, C., Guillemin, K. (2016) A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development. eLIFE. 5

Wiles, T.J., Jemielita, M., Baker, R.P., Schlomann, B.H., Logan, S.L., Ganz, J., Melancon, E., Eisen, J.S., Guillemin, K., Parthasarathy, R. (2016) Host Gut Motility Promotes Competitive Exclusion within a Model Intestinal Microbiota. PLoS Biology. 14:e1002517

Mason, T., Snell, K., Mittge, E., Melancon, E., Montgomery, R., McFadden, M., Camoriano, J., Kent, M.L., Whipps, C.M., Peirce, J. (2016) Strategies to Mitigate a Mycobacterium marinum Outbreak in a Zebrafish Research Facility. Zebrafish. 13 Suppl 1:S77-87

Burns, A.R., Zac Stephens, W., Stagaman, K., Wong, S., Rawls, J.F., Guillemin, K., Bohannan, B.J. (2016) Contribution of neutral processes to the assembly of gut microbial communities in the zebrafish over host development. The ISME Journal. 10(3):655-64

Zac Stephens, W., Burns, A.R., Stagaman, K., Wong, S., Rawls, J.F., Guillemin, K., Bohannan, B.J. (2016) The composition of the zebrafish intestinal microbial community varies across development. The ISME Journal. 10(3):644-54

Rolig, A.S., Parthasarathy, R., Burns, A.R., Bohannan, B.J., Guillemin, K. (2015) Individual Members of the Microbiota Disproportionately Modulate Host Innate Immune Responses. Cell Host & Microbe. 18:613-20

Stephens, W.Z., Wiles, T.J., Martinez, E.S., Jemielita, M., Burns, A.R., Parthasarathy, R., Bohannan, B.J., Guillemin, K. (2015) Identification of Population Bottlenecks and Colonization Factors during Assembly of Bacterial Communities within the Zebrafish Intestine. mBio. 6(6):e01163-15

Wong, S., Stephens, W.Z., Burns, A.R., Stagaman, K., David, L.A., Bohannan, B.J., Guillemin, K., Rawls, J.F. (2015) Ontogenetic Differences in Dietary Fat Influence Microbiota Assembly in the Zebrafish Gut. mBio. 6(5):e00687-15

Yang, Y., Millán, J.L., Mecsas, J., Guillemin, K. (2015) Intestinal alkaline phosphatase deficiency leads to lipopolysaccharide desensitization and faster weight gain. Infection and Immunity. 83(1):247-58

Jemielita, M., Taormina, M.J., Burns, A.R., Hampton, J.S., Rolig, A.S., Guillemin, K., Parthasarathy, R. (2014) Spatial and Temporal Features of the Growth of a Bacterial Species Colonizing the Zebrafish Gut. mBio. 5(6):1698-710

Paquette, C.E., Kent, M.L., Buchner, C., Tanguay, R.L., Guillemin, K., Mason, T.J., and Peterson, T.S. (2013) A Retrospective Study of the Prevalence and Classification of Intestinal Neoplasia in Zebrafish (Danio rerio). Zebrafish. 10(2):228-36

Neal, J.T., Peterson, T.S., Kent, M.L., and Guillemin, K. (2013) H. pylori Virulence Factor CagA Increases Intestinal Cell Proliferation by Wnt Pathway Activation in a Transgenic Zebrafish Model. Disease models & mechanisms. 6(3):802-10

Yang, Y., Wandler, A.M., Postlethwait, J.H., and Guillemin, K. (2012) Dynamic Evolution of the LPS-Detoxifying Enzyme Intestinal Alkaline Phosphatase in Zebrafish and Other Vertebrates. Frontiers in Molecular Innate Immunity. 3:314

Taormina, M.J., Jemielita, M., Stephens, W.Z., Burns, A.R., Troll, J.V., Parthasarathy, R., and Guillemin, K. (2012) Investigating bacterial-animal symbioses with light sheet microscopy. The Biological bulletin. 223(1):7-20

Roeselers, G., Mittge, E.K., Stephens, W.Z., Parichy, D.M., Cavanaugh, C.M., Guillemin, K., and Rawls, J.F. (2011) Evidence for a core gut microbiota in the zebrafish. The ISME Journal. 5(10):1595-608

Cheesman, S.E., Neal, J.T., Mittge, E., Seredick, B.M., and Guillemin, K. (2011) Epithelial cell proliferation in the developing zebrafish intestine is regulated by the Wnt pathway and microbial signaling via Myd88. Proceedings of the National Academy of Sciences of the United States of America. 108(Suppl 1):4570-4577

Milligan-Myhre, K., Charette, J.R., Phennicie, R.T., Stephens, W.Z., Rawls, J.F., Guillemin, K., and Kim, C.H. (2011) Study of host-microbe interactions in zebrafish. Methods in cell biology. 105:87-116

Bates, J.M., Akerlund, J., Mittge, E., and Guillemin, K. (2007) Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell Host & Microbe. 2(6):371-382

Baden, K.N., Murray, J., Capaldi, R.A., and Guillemin, K. (2007) Early developmental pathology due to cytochrome c oxidase deficiency is revealed by a new zebrafish model. The Journal of biological chemistry. 282(48):34839-34849

Hutchinson, S.A., Cheesman, S.E., Hale, L.A., Boone, J.Q., and Eisen, J.S. (2007) Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Development (Cambridge, England). 134(9):1671-1677

Bates, J.M. (2007) Molecular dialogues between the gut and its resident microbiota affect the development of the zebrafish intestine. Ph.D. Thesis. :82p

Cheesman, S.E., and Guillemin, K. (2007) We know you are in there: Conversing with the indigenous gut microbiota. Research in Microbiology. 158(1):2-9

Bates, J.M., Mittge, E., Kuhlman, J., Baden, K.N., Cheesman, S.E., and Guillemin, K. (2006) Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation. Developmental Biology. 297(2):374-386

Cheesman, S.E., and Eisen, J.S. (2004) gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafish. Gene expression patterns : GEP. 5(1):107-112

Cheesman, S.E., Layden, M.J., Von Ohlen, T., Doe, C.Q., and Eisen, J.S. (2004) Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation. Development (Cambridge, England). 131(21):5221-5232