ZFIN Company: ZECLINICS

ZFIN ID: ZDB-COMPANY-200115-1

ZFIN ID: ZDB-COMPANY-200115-1

ZECLINICS

Contact Person:	Miñana, Rafael
Email:	rafael.minana@zeclinics.com
URL:	http://www.zeclinics.com
Address:	c/ Marina 25-27 Baixos; 08005 BARCELONA
Country:	Spain
Phone:	+34 937 376 114
Fax:
Line Designation:	ze

PRODUCTS AND SERVICES

ZeClinics is a biotech Contract Research Organization (CRO) and early-phase biopharmaceutical
(PHARMA) company using zebrafish for safety and efficacy screenings of novel chemical
molecules and target genes. As leading CRISPR-licensed CRO using zebrafish as a model for
drug discovery, its core competencies are CRISPR-mediated genetic disease models, Target
validation, High Throughput Screening (HTS) of novel molecules, we perform toxicity and efficacy assays in several therapeutic areas:
cardiovascular, CNS and oncological, ophthalmology and muscular.

COMPANY REPRESENTATIVES

Miñana, Rafael Executive

Terriente, Javier Senior Scientist

Calzolari, Simone Technical

ZEBRAFISH PUBLICATIONS OF COMPANY REPRESENTATIVES

Hamm, J.T., Hsieh, J.H., Roberts, G.K., Collins, B., Gorospe, J., Sparrow, B., Walker, N.J., Truong, L., Tanguay, R.L., Dyballa, S., Miñana, R., Schiavone, V., Terriente, J., Weiner, A., Muriana, A., Quevedo, C., Ryan, K.R. (2024) Interlaboratory Study on Zebrafish in Toxicology: Systematic Evaluation of the Application of Zebrafish in Toxicology's (SEAZIT's) Evaluation of Developmental Toxicity. Toxics. 12(1):

Jarque, S., Rubio-Brotons, M., Ibarra, J., Ordoñez, V., Dyballa, S., Miñana, R., Terriente, J. (2020) Morphometric analysis of developing zebrafish embryos allows predicting teratogenicity modes of action in higher vertebrates. Reproductive toxicology (Elmsford, N.Y.). 96:337-348

Rubbini, D., Cornet, C., Terriente, J., Di Donato, V. (2020) CRISPR Meets Zebrafish: Accelerating the Discovery of New Therapeutic Targets. SLAS discovery : advancing life sciences R & D. 25(6):552-567

Younes, N., Pintus, G., Al-Asmakh, M., Rasool, K., Younes, S., Calzolari, S., Mahmoud, K.A., Nasrallah, G.K. (2020) "Safe" Chitosan/Zinc Oxide Nanocomposite Has Minimal Organ-Specific Toxicity in Early Stages of Zebrafish Development. ACS biomaterials science & engineering. 6:38-47

Cornet, C., Dyballa, S., Terriente, J., Di Giacomo, V. (2019) ZeOncoTest: Refining and Automating the Zebrafish Xenograft Model for Drug Discovery in Cancer. Pharmaceuticals (Basel, Switzerland). 13(1):

Dyballa, S., Miñana, R., Rubio-Brotons, M., Cornet, C., Pederzani, T., Escaramis, G., Garcia-Serna, R., Mestres, J., Terriente, J. (2019) Comparison of zebrafish larvae and hiPSC cardiomyocytes for predicting drug induced cardiotoxicity in humans. Toxicological sciences : an official journal of the Society of Toxicology. 171(2):283-95

Jarque, S., Ibarra, J., Rubio-Brotons, M., García-Fernández, J., Terriente, J. (2019) Multiplex Analysis Platform for Endocrine Disruption Prediction Using Zebrafish. International Journal of Molecular Sciences. 20(7):

Pant, D.C., Dorboz, I., Schlüter, A., Fourcade, S., Launay, N., Joya, J., Aguilera-Albesa, S., Yoldi, M.E., Casasnovas, C., Willis, M.J., Ruiz, M., Ville, D., Lesca, G., Siquier-Pernet, K., Desguerre, I., Yan, H., Wang, J., Burmeister, M., Brady, L., Tarnopolsky, M., Cornet, C., Rubbini, D., Terriente, J., James, K.N., Musaev, D., Zaki, M.S., Patterson, M.C., Lanpher, B.C., Klee, E.W., Pinto E Vairo, F., Wohler, E., Sobreira, N.L.M., Cohen, J.S., Maroofian, R., Galehdari, H., Mazaheri, N., Shariati, G., Colleaux, L., Rodriguez, D., Gleeson, J.G., Pujades, C., Fatemi, A., Boespflug-Tanguy, O., Pujol, A. (2019) Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy. The Journal of Clinical Investigation. 129(3):1240-1256

Cornet, C., Di Donato, V., Terriente, J. (2018) Combining Zebrafish and CRISPR/Cas9: Toward a More Efficient Drug Discovery Pipeline. Frontiers in pharmacology. 9:703

Cornet, C., Calzolari, S., Miñana-Prieto, R., Dyballa, S., van Doornmalen, E., Rutjes, H., Savy, T., D'Amico, D., Terriente, J. (2017) ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish. International Journal of Molecular Sciences. 18(4)

D'Amico, D., Estivill, X., Terriente, J. (2015) Switching to zebrafish neurobehavioral models: The obsessive-compulsive disorder paradigm. European Journal of Pharmacology. 759:142-50