- Title
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Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
- Authors
- Pozo-Morales, M., Cobham, A.E., Centola, C., McKinney, M.C., Liu, P., Perazzolo, C., Lefort, A., Libert, F., Bai, H., Rohner, N., Singh, S.P.
- Source
- Full text @ Life Sci Alliance
Response of cavefish and surface fish larvae to starvation. |
Reduction in the size of liver upon accumulation of lipid droplets during starvation. |
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FATP2 is an evolutionarily conserved regulator of starvation-induced lipidosis. |
A representative chromatogram of the |
Macrophages in the liver of 8 dpf zebrafish upon normal feeding. |
Accumulation of hepatic lipid droplets after removal of lipofermata. |
Transcriptional changes in the liver of 6 dpf fasting zebrafish upon lipofermata treatment. |
Lipofermata treatment does not impact animal growth, liver size in fed animals, or starvation resistance. |