- Title
-
Evidence for Adverse Effects on Liver Development and Regeneration in Zebrafish by Decabromodiphenyl Ethane
- Authors
- Li, F., Song, G., Wang, X., Sun, Y., Zhou, S., Zhang, Y., Hua, J., Zhu, B., Yang, L., Zhang, W., Zhou, B.
- Source
- Full text @ Env. Sci. Tech.
Effects of DBDPE on zebrafish larva liver development. (A) Liver morphology of Tg (fabp10a: dsRed; ela3l: EGFP) transgenic zebrafish larvae. Liver area (B) and fluorescence intensity (C) statistics of zebrafish larvae (n = 15). Data are expressed as the mean ± SEM. *P < 0.05 indicates significant differences between the exposure groups and their corresponding control. |
Transcription of genes related to liver development in zebrafish larvae. (A) WISH of fabp10a (n = 10). (B) Heat map of the qRT-PCR assay results. The red color indicates upregulation, the blue color indicates downregulation, and the color intensity is proportional to the magnitude of changes. (C) KEGG chord diagrams for genes. Regulatory relationships between genes in 1 nM (D) and 10 nM (E). The double helix represents gene transcription. Red and blue colors indicate upregulation and downregulation, respectively. Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 mean a significant difference between the exposure groups and the control. |
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