FIGURE SUMMARY
Title

New Phocoenamicin and Maklamicin Analogues from Cultures of Three Marine-Derived Micromonospora Strains

Authors
Kokkini, M., Oves-Costales, D., Sánchez, P., Melguizo, Á., Mackenzie, T.A., Pérez-Bonilla, M., Martín, J., Giusti, A., de Witte, P., Vicente, F., Genilloud, O., Reyes, F.
Source
Full text @ Mar. Drugs
Figure 1

Compounds 1–7 isolated from culture broths of Micromonospora sp. CA-214671, CA-214658 and CA-218877.
Figure 2

1H-1H COSY and key HMBC correlations for 1.
Figure 3

Key NOESY correlations observed in the structure of phocoenamicin D (1).
Figure 4

1H-1H COSY and key HMBC correlations for 6.
Figure 5

Key coupling constants (blue dashed) and NOESY (red) correlations establishing the configuration at C-31 for 6.
Figure 6

Mean scores of toxicity of the 5 dpf zebrafish eleuthero embryos after their exposure with (a) phocoenamicin, (b) phocoenamicin B and (c) maklamicin in five different concentrations (1.6–25 μM) and the control group (VHC). Three independent experiments were performed, the data were pooled and the mean ± SD was calculated. For the statistical analysis, the mean score of each concentration was compared with the mean scores of every other by using one-way ANOVA with Tukey’s multiple comparison test, p < 0.05.
Figure 7

Lateral view of 5 dpf eleuthero-embryos with no developmental abnormalities, after 48 h exposure, (a) with 25 μM of phocoenamicin (b) with 25 μM of phocoenamicin B, (c) with 25 μM of maklamicin and (d) Vehicle-treated Control eleuthero embryo (VHC).
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mar. Drugs
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