Fig. 1

PCA (A) and PLS-DA (B) plots representing the metabolite profiling of zebrafish embryos at 4, 24, 48, 72, and 120 hpf.

Fig. 2

The relative response of metabolites representative of various classes in zebrafish embryos at different developmental stages: 4 hpf (darkgrey), 24 hpf (orange), 48 hpf (darkblue), 72 hpf (red), and 120 hpf (black). All of the shown metabolites are significant compared to 4 hpf, for more details about significant differences between groups see Supplementary Materials.

Fig. 3

In zebrafish at 120 hpf, (A): Example of significantly affected metabolites by exposure to PFHxS at 0.3 μM (green), 1 μM (purple), 3 μM (blue), and 10 μM (pink), compared to the controls (red). (B): The four most affected metabolic pathways by 3 μM PFHxS. Other significantly affects metabolites can be found in Supplemental Materials.

Fig. 4

An overview of the dysregulated metabolic pathways by PFHxS and the affected metabolites by 3 μM PFHxS in zebrafish embryos at 120 hpf.

Acknowledgments
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