Human and zebrafish heart repair. Phases of repair/regeneration in human and zebrafish hearts post-injury, showing that initial inflammatory and scarring responses are similar, but the final stages diverge, with humans exhibiting persistent scar tissue and poor renewal of CMs. Zebrafish models of MI (e.g. cryoinjury shown here) exhibit a regenerative phase of scar resolution and CM proliferation, terminating in a return to healthy myocardium

Immune cell population and ECM dynamics during zebrafish cardiac repair/regeneration. Diagram adapted from data published by Bevan et al. (2020), showing relative waves of immune cell populations and collagen (specifically Collagen I) deposition as detected over a 60-day time period following cardiac cryoinjury. A colour-coded legend, including markers used to define the relative populations, is shown below the graph

Heart repair and regeneration requires a concerted effort by many different cell types. Representation of the numerous cell populations required throughout heart repair and regeneration in the adult zebrafish. Sample publications detailing the roles of these different cell types are listed in Table 1