FIGURE SUMMARY
Title

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

Authors
Louphrasitthiphol, P., Siddaway, R., Loffreda, A., Pogenberg, V., Friedrichsen, H., Schepsky, A., Zeng, Z., Lu, M., Strub, T., Freter, R., Lisle, R., Suer, E., Thomas, B., Schuster-Böckler, B., Filippakopoulos, P., Middleton, M., Lu, X., Patton, E.E., Davidson, I., Lambert, J.P., Wilmanns, M., Steingrímsson, E., Mazza, D., Goding, C.R.
Source
Full text @ Mol. Cell
Figure 4

K243 Controls MITF Function In Vivo

(A) Complementation of neural crest MITFa-null nacre zebrafish using MITF WT and K238 (equivalent to K243 in human MITF) mutants (left) and quantification of numbers of melanocytes (right). The dots in the plots represent numbers of melanocytes in each rescued embryo with at least one melanocyte. See also Figure S3.

(B) Western blot of 501mel cells stably expressing HA-MITF WT and mutants (from the same gel).

(C) Tumor formation after subcutaneous inoculation of indicated cell lines into athymic nude mice.

(D) Example tumors.

(E) Tumor size over time using indicated cell lines. Error bars indicate S.E.M.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Cell
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