FIGURE SUMMARY
Title

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

Authors
Garcia, E.G., Veloso, A., Oliveira, M.L., Allen, J.R., Loontiens, S., Brunson, D., Do, D., Yan, C., Morris, R., Iyer, S., Garcia, S.P., Iftimia, N., Van Loocke, W., Matthijssens, F., McCarthy, K., Barata, J.T., Speleman, F., Taghon, T., Gutierrez, A., Van Vlierberghe, P., Haas, W., Blackburn, J.S., Langenau, D.M.
Source
Full text @ Leukemia
Figure 1.

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Figure 3.

Figure 4.

PRL3 is required for human T-ALL growth and maintenance in mouse xenograft studies.

(A) Western blot analysis following shRNA knockdown in Jurkat cells. (B) Luciferase bioluminescent imaging of representative animal engrafted with scramble control shRNA (shSCR, left flank) compared with shRNA to PRL3 (sh#2, right flank). High exposure images shown on 0 day to ensure equal injection of control and knockdown cells (left panels). Animals shown at different exposure from 14–35 days to highlight relative differences in growth between control and knockdown cells (right panels). (C) Quantification of growth at different time points. * denotes p<0.05, ** denotes p<0.01, Student’s t-test. Error bars denote standard error of the mean. N ≥ 5 mice/experimental arm.
Figure 5.

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Figure 7.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Leukemia
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