FIGURE SUMMARY
Title

Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups

Authors
Tu, J., Svatunek, D., Parvez, S., Eckvahl, H.J., Xu, M., Peterson, R.T., Houk, K.N., Franzini, R.M.
Source
Full text @ Chem Sci
Fig. 7

Dual release of two orthogonal fluorophores from ICPr- and TzMe-caged dyes in live zebrafish. (a) Cartoon representation of experiment demonstrating the dual release and fluorescence turn-on of <italic>O</italic>-carboxymethyl fluorescein and resorufin upon reaction of <bold>4b</bold> and <bold>ICPr-rsf</bold>, and the corresponding control experiment with non-injected fish. (b) Visualization of fluorescein and resorufin fluorescence signal in live zebrafish (scale bar = 200 μm) injected with <bold>4b</bold> after a 2 h incubation with 10 μM <bold>ICPr-rsf</bold>. (c) Visualization of fluorescein and resorufin fluorescence signal in non-<bold>4b</bold> injected control live zebrafish (scale bar = 200 μm) after a 2 h incubation with 10 μM <bold>ICPr-rsf</bold>.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Chem Sci
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