FIGURE SUMMARY
Title

De novo genesis of retinal ganglion cells by targeted expression of Klf4 in vivo

Authors
Rocha-Martins, M., de Toledo, B.C., Santos-França, P.L., Oliveira-Valença, V.M., Vieira-Vieira, C.H., Matos-Rodrigues, G.E., Linden, R., Norden, C., Martins, R.A.P., Silveira, M.S.
Source
Full text @ Development
Fig. 1

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Fig. S1

Characterization of conditional Klf4 mice and zebrafish knockout. (A) Klf4 RNA content from E15.5 to P60 in wild type mice. (B) qRT-PCR for Klf4 of RNA isolated from Klf4CTR and Klf4Cre. (C) Measurements of eye volume in Klf4CTR (n=8) and Klf4Cre (n=5). (D, E) Eyes from Klf4CTR and Klf4Cre show no apparent difference. (F, G) Histological comparison between retinal sections from Klf4CTR and Klf4Cre. (H, I) No difference is seen in the optic nerve or optic chiasma. (J, K) Zebrafish embryos 48hpf from Klf4+/+ and Klf4del/del genotypes. (L) Detailed characterization of deletion and comparison with aligned sequences from mice and humans. Scale bar = 500 μm (D, E, H, I), 25 μm (F, G) or 200 μm (J, K).

PHENOTYPE:
Fish:
Observed In:
Stage: Long-pec
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development
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