FIGURE SUMMARY
Title

Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking

Authors
Lyu, J., Yang, E.J., Head, S.A., Ai, N., Zhang, B., Wu, C., Li, R.J., Liu, Y., Chakravarty, H., Zhang, S., Tam, K.Y., Dang, Y., Kwon, H.J., Ge, W., Liu, J.O., Shim, J.S.
Source
Full text @ Int. J. Biol. Sci.
Fig. 6

Astemizole inhibits zebrafish angiogenesis in a cholesterol-dependent manner. The Tg(fli1:EGFP)y1 zebrafish embryos (8 hpf) were microinjected with astemizole (AST, final dosage of 0.3 ng or 0.6 ng/embryo) with or without cholesterol-cyclodextrin complex (CHOL, final dosage of 3.7 ng in 10% cyclodextrin/embryo). (A) The representative zebrafish images were taken at 72 hpf. Scale bar = 500 μm. The image inlets (white square) magnifying sub-intestinal vessels (SIV) are shown at the bottom of each image. Scale bar = 200 μm. (B) Zebrafish SIV angiogenesis was quantified by counting the number of SIV branch points. *P<0.05; **P<0.01 between two groups.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Biol. Sci.
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