FIGURE SUMMARY
- Title
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Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation
- Authors
- Chen, M.B., Hajal, C., Benjamin, D.C., Yu, C., Azizgolshani, H., Hynes, R.O., Kamm, R.D.
- Source
- Full text @ Proc. Natl. Acad. Sci. USA
Inflamed PMNs are sequestered at TC–PMN clusters and enhance extravasation rates of A375 and MA2 in vivo. (A) Intravascular cluster-associated and free PMNs (pink) when coinjected with MA2 cells (green) in flk:dsRed (red) zebrafish embryos. (B) Migration tracks of cluster-associated or free PMNs in vessels of zebrafish embryos. (C) Extravasation rates of A375 and MA2 cells with or without coperfusion with inflamed PMNs at 6 h and 24 h (n = 7–12 embryos for A375, n = 18–23 embryos for MA2). Error bars indicate SEM, **P < 0.01, ***P < 0.001. |
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Full text @ Proc. Natl. Acad. Sci. USA