FIGURE SUMMARY
- Title
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The role of histone modification and a regulatory single-nucleotide polymorphism (rs2071166) in the Cx43 promoter in patients with TOF
- Authors
- Gu, R., Xu, J., Lin, Y., Sheng, W., Ma, D., Ma, X., Huang, G.
- Source
- Full text @ Sci. Rep.
A regulatory variant in Cx43 abrogates RARE function. pCNE-Cx43-A (A allele) or pCNE-Cx43-C (C allele) was injected into zebrafish with Tol2 mRNA. The plasmid containing a 500 bp promoter region within the WT-RARE drove cardiac expression in zebrafish. When mutated, it lost RARE activity. (a,b,c) Wild-type zebrafish without vector injection. (d,e,f) Zebrafish injected with pCNE-Cx43-A. (g,h,i) Zebrafish injected with pCNE-Cx43-C. |
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Full text @ Sci. Rep.