FIGURE SUMMARY
- Title
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Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1
- Authors
- Miyata, N., Steffen, J., Johnson, M.E., Fargue, S., Danpure, C.J., Koehler, C.M.
- Source
- Full text @ Proc. Natl. Acad. Sci. USA
A high concentration of DECA is required to inhibit zebrafish development. (A) DECA at the indicated concentrations was dissolved in 0.5% DMSO and incubated with zebrafish embryos 3 h postfertilization (hpf). Larvae were photographed at 3 d postfertilization (dpf) (B) As in A, but DECA was dissolved in a ratio of 10% H2O/90% DMSO (vol/vol) because of limited solubility in DMSO. Embryos were treated as in A. (C) Embryos were incubated as in A with CCCP. PHENOTYPE:
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Acknowledgments
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Full text @ Proc. Natl. Acad. Sci. USA