- Title
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Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer
- Authors
- Murphy, A.G., Casey, R., Maguire, A., Tosetto, M., Butler, C.T., Conroy, E., Reynolds, A.L., Sheahan, K., O'Donoghue, D., Gallagher, W.M., Fennelly, D., Kennedy, B.N., O'Sullivan, J.
- Source
- Full text @ Sci. Rep.
Quininib reduces intersegmental blood vessel formation in zebrafish larvae. (A) Chemical structure of 2-[(E)-2-(Quinolin-2-yl) vinyl] phenol (quininib). (B,C) Representative images of larvae treated with vehicle control (B) and 10 μM quininib (C). The white arrows in (C) demonstrate the absence of ISV and the green arrow shows the presence of pericardial oedema and magnified views of ISVs are inset in the right upper corner of each panel. (D) Quininib reduced ISV number at 5 μM (12%), 7.5 μM (18.8%) and 10 μM concentration (33%). (E) Quininib reduced larval length at 10 μM. Error bars are mean + SEM. Statistical analysis performed by ANOVA and Dunnett’s multiple comparison test. N = 3 experiments with 10 embryos per concentration *p < 0.05, **p < 0.01, ***p < 0.001. |