FIGURE SUMMARY
Title

Automated, high-throughput, in vivo analysis of visual function using the zebrafish

Authors
Scott, C.A., Marsden, A.N., Slusarski, D.C.
Source
Full text @ Dev. Dyn.
Fig. 6

Knockdown of cone-rod homeobox shows VSR defects. Wild-type (A) and CRX morphant (B) larvae were subjected to the automated VSR and analyzed with VIZN. CRX morphant larvae responded less than WT to the visual stimuli (C), box-and-whisker plot representing minimum, maximum, and quartiles, t-test P-value < 0.05.
Fig. 7

Eyeless embryos do not respond to VSR. By 2dpf, uninjected embryos have begun to develop eyes (A). Wnt8 injection prevents proper development of these structures (B). These larvae were raised to 5dpf and analyzed with VIZN along with wild-type siblings. These “eyeless” larva have an average VSR of 0.4, indicating VIZN does not detect spontaneous movements as responses (C), box-and-whisker plot showing minimum, maximum, and quartiles, t-test P-value < 0.0001.
Acknowledgments
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