FIGURE SUMMARY
Title

Identification of Small Molecule Activators of BMP Signaling

Authors
Vrijens, K., Lin, W., Cui, J., Farmer, D., Low, J., Pronier, E., Zeng, F.Y., Shelat, A.A., Guy, K., Taylor, M.R., Chen, T., and Roussel, M.F.
Source
Full text @ PLoS One
Fig. 7

Effects of small molecules on zebrafish embryonic development.

(A1.) Zebrafish embryos were treated from 2 to 50 hpf with DMSO as a negative control, (A2.) with 10 μM dorsomorphin to dorsalize the embryos, or (A3.) injected with a chordin morpholino to ventralize the embryos. (B-E.) treatment with 5 and 10 μM isoliquiritigenin (B1,2), 5 and 10 μM 4′-hydroxychalcone (C1, 2), 10 and 20 μM apigenin (D1, 2), and 5 and 10 μM diosmetin (E1, 2) ventralized the embryos. Embryos were imaged at 50 hpf. At least 15 animals were analyzed per concentration and per compound. Images represent the phenotype found in e33% of animals in the respective groups. Arrow indicates the loss of the ventral tail fin. Scale bar, 500 μm.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One
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