ZFIN ID: ZDB-PERS-160212-1
Astin, Jonathan
Email: j.astin@auckland.ac.nz
URL:
Affiliation: Astin Lab
Address: Department of Molecular Medicine and Pathology Faculty of Medical and Health Sciences The University of Auckland 85 Park Road, Grafton 1023 Auckland, New Zealand
Country: New Zealand
Phone: +64 9 923 4480
Fax:
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Darroch, H., Astin, J.W., Hall, C.J. (2023) Microinjection of β-glucan Into Larval Zebrafish (Danio rerio) for the Assessment of a Trained-Like Immunity Phenotype. Bio-protocol. 13:e4888e4888
Riisom, M., Morrow, S.J., Herbert, C.D., Tremlett, W.D.J., Astin, J.W., Jamieson, S.M.F., Hartinger, C.G. (2023) In vitro and in vivo accumulation of the anticancer Ru complexes [RuII(cym)(HQ)Cl] and [RuII(cym)(PCA)Cl]Cl. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 28(8):767-775
Darroch, H., Keerthisinghe, P., Sung, Y.J., Rolland, L., Prankerd-Gough, A., Crosier, P.S., Astin, J.W., Hall, C.J. (2023) Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity. Science advances. 9:eadf9904eadf9904
Sullivan, M.P., Adams, M., Riisom, M., Herbert, C.D., Tong, K.K.H., Astin, J.W., Jamieson, S.M.F., Hanif, M., Goldstone, D.C., Hartinger, C.G. (2023) Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo. Dalton transactions (Cambridge, England : 2003). 52(5):1388-1392
Linnerz, T., Sung, Y.J., Rolland, L., Astin, J.W., Dalbeth, N., Hall, C.J. (2022) Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence. Genes. 13(12):
Britto, D.D., He, J., Misa, J.P., Chen, W., Kakadia, P.M., Grimm, L., Herbert, C.D., Crosier, K.E., Crosier, P.S., Bohlander, S.K., Hogan, B.M., Hall, C.J., Torres-Vázquez, J., Astin, J.W. (2022) Plexind1 negatively regulates zebrafish lymphatic development. Development (Cambridge, England). 149(21)
Hall, C.J., Astin, J.W., Mumm, J.S., Ackerley, D.F. (2022) A New Transgenic Line for Rapid and Complete Neutrophil Ablation. Zebrafish. 19(3):109-113
Darroch, H., Astin, J.W., Hall, C.J. (2022) Towards a new model of trained immunity: Exposure to bacteria and β-glucan protects larval zebrafish against subsequent infections. Developmental and comparative immunology. 132:104400
Hanif, M., Arshad, J., Astin, J., Rana, Z., Zafar, A., Movassaghi, S., Leung, E., Patel, K., Soehnel, T., Reynisson, J., Sarojini, V., Rosengren, R., Jamieson, S., Hartinger, C. (2020) A Multitargeted Approach in the Discovery of an Organorhodium Anticancer Agent Based On Vorinostat as a Potent Histone Deacetylase Inhibitor. Angewandte Chemie (International ed. in English). 59(34):14609-14614
Linnerz, T., Kanamala, M., Astin, J.W., Dalbeth, N., Wu, Z., Hall, C.J. (2020) Targeting Drugs to Larval Zebrafish Macrophages by Injecting Drug-Loaded Liposomes. Journal of visualized experiments : JoVE. (156):
Parveen, S., Hanif, M., Leung, E., Tong, K.K.H., Yang, A., Astin, J., De Zoysa, G.H., Steel, T.R., Goodman, D., Movassaghi, S., Söhnel, T., Sarojini, V., Jamieson, S.M.F., Hartinger, C.G. (2019) Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity. Chemical communications (Cambridge, England). 55(80):12016-12019
Britto, D.D., Hall, C.J., Astin, J.W. (2019) In Vivo Imaging and Quantitation of the Host Angiogenic Response in Zebrafish Tumor Xenografts. Journal of visualized experiments : JoVE. (150):
Eng, T.C., Chen, W., Okuda, K.S., Misa, J.P., Padberg, Y., Crosier, K.E., Crosier, P.S., Hall, C.J., Schulte-Merker, S., Hogan, B.M., Astin, J.W. (2019) Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors. EMBO reports. 20(5):
Wu, Z., Koh, B., Lawrence, L.M., Kanamala, M., Pool, B., Svirskis, D., Dalbeth, N., Astin, J.W., Crosier, K.E., Crosier, P.S., Hall, C.J. (2019) Liposome-Mediated Drug Delivery in Larval Zebrafish to Manipulate Macrophage Function. Zebrafish. 16(2):171-181
Britto, D.D., Wyroba, B., Chen, W., Lockwood, R.A., Tran, K.B., Shepherd, P.R., Hall, C.J., Crosier, K.E., Crosier, P.S., Astin, J.W. (2018) Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model. Disease models & mechanisms. 11(12):
Hall, C.J., Sanderson, L.E., Lawrence, L.M., Pool, B., van der Kroef, M., Ashimbayeva, E., Britto, D., Harper, J.L., Lieschke, G.J., Astin, J.W., Crosier, K.E., Dalbeth, N., Crosier, P.S. (2018) Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. The Journal of Clinical Investigation. 128(5):1752-1771
Eng, T.C.Y., Astin, J.W. (2018) Characterization of Zebrafish Facial Lymphatics. Methods in molecular biology (Clifton, N.J.). 1846:71-83
Du, L.Y., Darroch, H., Keerthisinghe, P., Ashimbayeva, E., Astin, J.W., Crosier, K.E., Crosier, P.S., Warman, G., Cheeseman, J., Hall, C.J. (2017) The innate immune cell response to bacterial infection in larval zebrafish is light-regulated. Scientific Reports. 7:12657
Astin, J.W., Keerthisinghe, P., Du, L., Sanderson, L.E., Crosier, K.E., Crosier, P.S., Hall, C.J. (2017) Innate immune cells and bacterial infection in zebrafish. Methods in cell biology. 138:31-60
Astin, J.W., Crosier, P.S. (2016) Lymphatics, Cancer and Zebrafish. Advances in experimental medicine and biology. 916:199-218

NON-ZEBRAFISH PUBLICATIONS