ZFIN Person: Roca, Francisco Jose

ZFIN ID: ZDB-PERS-110228-3

Roca, Francisco Jose

Email:	froca@mrc-lmb.cam.ac.uk
URL:
Affiliation:	Ramakrishnan Lab
Address:	Molecular Immunity Unit Department of Medicine University of Cambridge MRC-Laboratory of Molecular Biology Francis Crick Avenue Cambridge Biomedical Campus Cambridge, CB2 0HQ
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BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Fan, J., Hale, V.L., Lelieveld, L.T., Whitworth, L.J., Busch-Nentwich, E.M., Troll, M., Edelstein, P.H., Cox, T.M., Roca, F.J., Aerts, J.M.F.G., Ramakrishnan, L. (2023) Gaucher disease protects against tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 120:e2217673120e2217673120

Roca, F.J., Whitworth, L.J., Prag, H.A., Murphy, M.P., Ramakrishnan, L. (2022) Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport. Science (New York, N.Y.). 376:eabh2841

Takaki, K.K., Roca, F.J., Schramm, G., Wilbers, R.H.P., Ittiprasert, W., Brindley, P.J., Rinaldi, G., Berriman, M., Ramakrishnan, L., Pagán, A.J. (2021) Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response. PLoS neglected tropical diseases. 15:e0008814

Roca, F.J., Whitworth, L.J., Redmond, S., Jones, A.A., Ramakrishnan, L. (2019) TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit. Cell. 178(6):1344-1361.e11

Espín-Palazón, R., Martínez-López, A., Roca, F.J., López-Muñoz, A., Tyrkalska, S.D., Candel, S., García-Moreno, D., Falco, A., Meseguer, J., Estepa, A., Mulero, V. (2016) TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response. PLoS pathogens. 12:e1005699

Roca, F.J., and Ramakrishnan, L. (2013) TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species. Cell. 153(3):521-34

Espín, R., Roca, F.J., Candel, S., Sepulcre, M.P., González-Rosa, J.M., Alcaraz-Pérez, F., Meseguer, J., Cayuela, M.L., Mercader, N., and Mulero, V. (2013) TNF receptors regulate vascular homeostasis through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Disease models & mechanisms. 6(2):383-396

Tobin, D.M., Roca, F.J., Oh, S.F., McFarland, R., Vickery, T.W., Ray, J.P., Ko, D.C., Zou, Y., Bang, N.D., Chau, T.T., Vary, J.C., Hawn, T.R., Dunstan, S.J., Farrar, J.J., Thwaites, G.E., King, M.C., Serhan, C.N., and Ramakrishnan, L. (2012) Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 148(3):434-446

NON-ZEBRAFISH PUBLICATIONS