ZFIN ID: ZDB-PERS-050516-3
Pei, Wuhong
Email: peiw@mail.nih.gov
URL:
Affiliation: Burgess Lab
Address: Medical Genetics Branch National Institutes of Health DHHS Building 35, Room 1B-209 35 Convent Drive MSC 3717 Bethesda, MD 20892 USA
Country: United States
Phone:
Fax:
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Weinstein, R., Bishop, K., Broadbridge, E., Yu, K., Carrington, B., Elkahloun, A., Zhen, T., Pei, W., Burgess, S.M., Liu, P., Bresciani, E., Sood, R. (2022) Zrsr2 Is Essential for the Embryonic Development and Splicing of Minor Introns in RNA and Protein Processing Genes in Zebrafish. International Journal of Molecular Sciences. 23(18)
Wang, L., Astone, M., Alam, S.K., Zhu, Z., Pei, W., Frank, D.A., Burgess, S.M., Hoeppner, L.H. (2021) Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability. Disease models & mechanisms. 14(11):
Pei, W., Xu, L., Chen, Z., Slevin, C.C., Pettie, K.P., Wincovitch, S., NISC Comparative Sequencing Program, Burgess, S.M. (2020) A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation. NPJ Regenerative medicine. 5:6
McElderry, J., Carrington, B., Bishop, K., Kim, E., Pei, W., Chen, Z., Ramanagoudr-Bhojappa, R., Prakash, A., Burgess, S.M., Liu, P.P., Sood, R. (2019) Splicing factor DHX15 affects tp53 and mdm2 expression via alternate splicing and promoter usage. Human molecular genetics. 28(24):4173-4185
Pei, W., Burgess, S.M. (2019) Microinjection in Zebrafish for Genome Editing and Functional Studies. Methods in molecular biology (Clifton, N.J.). 1874:459-474
Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
Tseng, W.C., Loeb, H.E., Pei, W., Tsai-Morris, C.H., Xu, L., Cluzeau, C.V., Wassif, C.A., Feldman, B., Burgess, S.M., Pavan, W.J., Porter, F.D. (2018) Modeling Niemann-Pick disease type C1 in zebrafish: a robust platform for in vivo screening of candidate therapeutic compounds.. Disease models & mechanisms. 11(9)
Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
Giannelou, A., Wang, H., Zhou, Q., Park, Y.H., Abu-Asab, M.S., Ylaya, K., Stone, D.L., Sediva, A., Sleiman, R., Sramkova, L., Bhatla, D., Serti, E., Tsai, W.L., Yang, D., Bishop, K., Carrington, B., Pei, W., Deuitch, N., Brooks, S., Edwan, J.H., Joshi, S., Prader, S., Kaiser, D., Owen, W.C., Sonbul, A.A., Zhang, Y., Niemela, J.E., Burgess, S.M., Boehm, M., Rehermann, B., Chae, J., Quezado, M.M., Ombrello, A.K., Buckley, R.H., Grom, A.A., Remmers, E.F., Pachlopnik, J.M., Su, H.C., Gutierrez-Cruz, G., Hewitt, S.M., Sood, R., Risma, K., Calvo, K.R., Rosenzweig, S.D., Gadina, M., Hafner, M., Sun, H.W., Kastner, D.L., Aksentijevich, I. (2018) Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors. Annals of the rheumatic diseases. 77(4):612-619
Li, H., Pei, W., Vergarajauregui, S., Zerfas, P.M., Raben, N., Burgess, S.M., Puertollano, R. (2017) Novel Degenerative and Developmental Defects in a Zebrafish Model of Mucolipidosis Type IV. Human molecular genetics. 26(14):2701-2718
Varshney, G.K., Carrington, B., Pei, W., Bishop, K., Chen, Z., Fan, C., Xu, L., Jones, M., LaFave, M.C., Ledin, J., Sood, R., Burgess, S.M. (2016) A high-throughput functional genomics workflow based on CRISPR/Cas9-mediated targeted mutagenesis in zebrafish. Nature Protocols. 11:2357-2375
Pei, W., Huang, S.C., Xu, L., Pettie, K., Ceci, M.L., Sánchez, M., Allende, M.L., Burgess, S.M. (2016) Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish.. Cell regeneration (London, England). 5:3
Pei, W., Xu, L., Varshney, G.K., Carrington, B., Bishop, K., Jones, M., Huang, S.C., Idol, J., Pretorius, P.R., Beirl, A., Schimmenti, L.A., Kindt, K.S., Sood, R., Burgess, S.M. (2016) Additive reductions in zebrafish PRPS1 activity result in a spectrum of deficiencies modeling several human PRPS1-associated diseases. Scientific Reports. 6:29946
Varshney, G.K., Zhang, S., Pei, W., Adomako-Ankomah, A., Fohtung, J., Schaffer, K., Carrington, B., Maskeri, A., Slevin, C., Wolfsberg, T., Ledin, J., Sood, R., Burgess, S.M. (2016) CRISPRz: a database of zebrafish validated sgRNAs. Nucleic acids research. 44(D1):D822-6
Varshney, G.K., Pei, W., LaFave, M.C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S.C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S.M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research. 25(7):1030-42
Zhou, Q., Yang, D., Ombrello, A.K., Zavialov, A.V., Toro, C., Zavialov, A.V., Stone, D.L., Chae, J.J., Rosenzweig, S.D., Bishop, K., Barron, K.S., Kuehn, H.S., Hoffmann, P., Negro, A., Tsai, W.L., Cowen, E.W., Pei, W., Milner, J.D., Silvin, C., Heller, T., Chin, D.T., Patronas, N.J., Barber, J.S., Lee, C.C., Wood, G.M., Ling, A., Kelly, S.J., Kleiner, D.E., Mullikin, J.C., Ganson, N.J., Kong, H.H., Hambleton, S., Candotti, F., Quezado, M.M., Calvo, K.R., Alao, H., Barham, B.K., Jones, A., Meschia, J.F., Worrall, B.B., Kasner, S.E., Rich, S.S., Goldbach-Mansky, R., Abinun, M., Chalom, E., Gotte, A.C., Punaro, M., Pascual, V., Verbsky, J.W., Torgerson, T.R., Singer, N.G., Gershon, T.R., Ozen, S., Karadag, O., Fleisher, T.A., Remmers, E.F., Burgess, S.M., Moir, S.L., Gadina, M., Sood, R., Hershfield, M.S., Boehm, M., Kastner, D.L., Aksentijevich, I. (2014) Early-onset stroke and vasculopathy associated with mutations in ADA2. The New England Journal of Medicine. 370(10):911-920
Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
Pei, W., Kratz, L.E., Bernardini, I., Sood, R., Yokogawa, T., Dorward, H., Ciccone, C., Kelley, R.I., Anikster, Y., Burgess, H.A., Huizing, M., and Feldman, B. (2010) A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3. Development (Cambridge, England). 137(15):2587-2596
Pei, W., and Feldman, B. (2009) Identification of common and unique modifiers of zebrafish midline bifurcation and cyclopia. Developmental Biology. 326(1):201-211
Pei, W., Noushmehr, H., Costa, J., Ouspenskaia, M.V., Elkahloun, A.G., and Feldman, B. (2007) An early requirement for maternal FoxH1 during zebrafish gastrulation. Developmental Biology. 310(1):10-22
Pei, W., Williams, P.H., Clark, M.D., Stemple, D.L., and Feldman, B. (2007) Environmental and genetic modifiers of squint penetrance during zebrafish embryogenesis. Developmental Biology. 308(2):368-378

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