ZFIN ID: ZDB-LAB-981015-6
Whitfield Lab
PI/Director: Whitfield, Tanya T.
Co-PI / Senior
Researcher:
Baxendale, Sarah
Contact Person: Whitfield, Tanya T.
Email: t.whitfield@sheffield.ac.uk
URL: https://www.sheffield.ac.uk/bms/research/whitfield
Address: Department of Biomedical Science University of Sheffield SHEFFIELD S10 2TN UK
Country: United Kingdom
Phone: 44-114-222-2350
Fax: +44 114 222 2787
Line Designation: sh


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 4 genomic features


STATEMENT OF RESEARCH INTERESTS
Development of vertebrate sensory systems, including the inner ear, lateral line and olfactory system.

Please see my web page for details.


LAB MEMBERS
Van Hateren, Nicholas J. Post-Doc Almeida Jones, Ana Graduate Student Asad, Anzar Graduate Student
Cheung, King Yee Graduate Student Glendenning, Emily Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Asad, A., Shahidan, N.O., de la Vega de León, A., Wiggin, G.R., Whitfield, T.T., Baxendale, S. (2023) A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126 signalling pathway in zebrafish embryos. Basic & Clinical Pharmacology & Toxicology. 133(4):364-377
Morsli, S., Henriques, C.M., Ellis, P.S., Mortiboys, H., Baxendale, S., Loynes, C.A., Renshaw, S.A., Bellantuono, I. (2023) A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo. Aging Cell. 22(6):e13835
Baldera, D., Baxendale, S., van Hateren, N.J., Marzo, M., Glendenning, E., Geng, F.S., Yokoya, K., Knight, R.D., Whitfield, T.T. (2023) Enhancer trap lines with GFP driven by smad6b and frizzled1 regulatory sequences for the study of epithelial morphogenesis in the developing zebrafish inner ear. Journal of anatomy. 243(1):78-89
Jones, A.A., Diamantopoulou, E., Baxendale, S., Whitfield, T.T. (2022) Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear. Frontiers in cell and developmental biology. 10:959624
Crouzier, L., Richard, E.M., Diez, C., Alzaeem, H., Denus, M., Cubedo, N., Delaunay, T., Glendenning, E., Baxendale, S., Liévens, J.C., Whitfield, T.T., Maurice, T., Delprat, B. (2022) Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines. Human molecular genetics. 31(16):2711-2727
Mendonca, T., Jones, A.A., Pozo, J.M., Baxendale, S., Whitfield, T.T., Frangi, A.F. (2021) Origami: Single-cell 3D shape dynamics oriented along the apico-basal axis of folding epithelia from fluorescence microscopy data. PLoS Computational Biology. 17:e1009063
Baxendale, S., Asad, A., Shahidan, N.O., Wiggin, G.R., Whitfield, T.T. (2021) The adhesion GPCR Adgrg6 (Gpr126): Insights from the zebrafish model. Genesis (New York, N.Y. : 2000). 59(4):e23417
Kenyon, E.J., Kirkwood, N.K., Kitcher, S.R., Goodyear, R.J., Derudas, M., Cantillon, D.M., Baxendale, S., de la Vega de León, A., Mahieu, V.N., Osgood, R.T., Donald Wilson, C., Bull, J.C., Waddell, S.J., Whitfield, T.T., Ward, S.E., Kros, C.J., Richardson, G.P. (2021) Identification of a novel series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity. JCI insight. 6(7)
Cheung, K.Y., Jesuthasan, S.J., Baxendale, S., van Hateren, N.J., Marzo, M., Hill, C.J., Whitfield, T.T. (2021) Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection. Frontiers in Physiology. 12:626080
Jones, A., Barker-Haliski, M., Ilie, A.S., Herd, M.B., Baxendale, S., Holdsworth, C.J., Ashton, J.P., Placzek, M., Jayasekera, B.A.P., Cowie, C.J.A., Lambert, J.J., Trevelyan, A.J., White, H.S., Marson, A.G., Cunliffe, V.T., Sills, G.J., Morgan, A. (2020) A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant. Epilepsia. 61(10):2106-2118
Whitfield, T.T. (2020) Cilia in the developing zebrafish ear. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 375:20190163
Toms, M., Dubis, A.M., de Vrieze, E., Tracey-White, D., Mitsios, A., Hayes, M., Broekman, S., Baxendale, S., Utoomprurkporn, N., Bamiou, D., Bitner-Glindzicz, M., Webster, A.R., Van Wijk, E., Moosajee, M. (2020) Clinical and preclinical therapeutic outcome metrics for USH2A-related disease. Human molecular genetics. 29(11):1882-1899
Diamantopoulou, E., Baxendale, S., de la Vega de León, A., Asad, A., Holdsworth, C.J., Abbas, L., Gillet, V.J., Wiggin, G.R., Whitfield, T.T. (2019) Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant. eLIFE. 8:
Hartwell, R.D., England, S.J., Monk, N.A.M., van Hateren, N.J., Baxendale, S., Marzo, M., Lewis, K.E., Whitfield, T.T. (2019) Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression. PLoS Genetics. 15:e1008051
Kenyon, E.J., Kirkwood, N.K., Kitcher, S.R., O'Reilly, M., Derudas, M., Cantillon, D.M., Goodyear, R.J., Secker, A., Baxendale, S., Bull, J.C., Waddell, S.J., Whitfield, T.T., Ward, S.E., Kros, C.J., Richardson, G.P. (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. JCI insight. 2(24)
Alsina, B., Whitfield, T.T. (2017) Sculpting the labyrinth: morphogenesis of the developing inner ear. Seminars in cell & developmental biology. 65:47-59
Gurung, R., Ono, Y., Baxendale, S., Lee, S.L., Moore, S., Calvert, M., Ingham, P.W. (2017) The Zebrafish frozen Mutant Is a Model for Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B. Genetics. 205(2):725-735
Baxendale, S., van Eeden, F., Wilkinson, R. (2017) The Power of Zebrafish in Personalised Medicine. Advances in experimental medicine and biology. 1007:179-197
Baxendale, S., Whitfield, T.T. (2016) Methods to study the development, anatomy, and function of the zebrafish inner ear across the life course. Methods in cell biology. 134:165-209
Stooke-Vaughan, G.A., Obholzer, N.D., Baxendale, S., Megason, S.G., Whitfield, T.T. (2015) Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin. Development (Cambridge, England). 142(6):1137-45
Maier, E.C., Whitfield, T.T. (2014) RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities. PLoS Genetics. 10:e1004858
Geng, F.S., Abbas, L., Baxendale, S., Holdsworth, C.J., Swanson, A.G., Slanchev, K., Hammerschmidt, M., Topczewski, J., and Whitfield, T.T. (2013) Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development (Cambridge, England). 40(21):4362-4374
Whitfield, T.T. (2013) Shedding new light on the origins of olfactory neurons. eLIFE. 2:e00648
Baxendale, S., Holdsworth, C.J., Santoscoy, P.M., Harrison, M.R., Fox, J., Parkin, C.A., Ingham, P.W., and Cunliffe, V.T. (2012) Identification of compounds with novel anti-convulsant properties in a zebrafish model of epileptic seizures. Disease models & mechanisms. 5(6):773-784
Stooke-Vaughan, G.A., Huang, P., Hammond, K.L., Schier, A.F., and Whitfield, T.T. (2012) The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development (Cambridge, England). 139(10):1777-1787
Buck, L.M., Winter, M.J., Redfern, W.S., and Whitfield, T.T. (2012) Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish. Hearing Research. 284(1-2):67-81
Hammond, K.L., and Whitfield, T.T. (2011) Fgf and Hh signalling act on a symmetrical pre-pattern to specify anterior and posterior identity in the zebrafish otic placode and vesicle. Development (Cambridge, England). 138:3977-3987
Thompson, M.J., Louth, J.C., Ferrara, S., Jackson, M.P., Sorrell, F.J., Cochrane, E.J., Gever, J., Baxendale, S., Silber, B.M., Roehl, H.H., and Chen, B. (2011) Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity. European Journal of Medicinal Chemistry. 46(9):4125-32
Abbas, L., Hajihashemi, S., Stead, L.F., Cooper, G.J., Ware, T.L., Munsey, T.S., Whitfield, T.T., and White, S.J. (2011) Functional and developmental expression of a zebrafish Kir1.1 (ROMK) potassium channel homologue Kcnj1. The Journal of physiology. 589(Pt 6):1489-503
Hammond, K.L., van Eeden, F.J., and Whitfield, T.T. (2010) Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle. Development (Cambridge, England). 137(8):1361-1371
Hammond, K.L., and Whitfield, T.T. (2009) Expression of zebrafish hip: response to Hedgehog signalling, comparison with ptc1 expression, and possible role in otic patterning. Gene expression patterns : GEP. 9(6):391-396
Abbas, L., and Whitfield, T.T. (2009) Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva. Development (Cambridge, England). 136(16):2837-2848
Baxendale, S., Chen, C.K., Tang, H., Davison, C., Hateren, L.V., Croning, M.D., Humphray, S.J., Hubbard, S.J., and Ingham, P.W. (2009) Expression screening and annotation of a zebrafish myoblast cDNA library. Gene expression patterns : GEP. 9(2):73-82
Dutton, K., Abbas, L., Spencer, J., Brannon, C., Mowbray, C., Nikaido, M., Kelsh, R.N., and Whitfield, T.T. (2009) A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle. Disease models & mechanisms. 2(1-2):68-83
Hammond, K.L., Baxendale, S., McCauley, D.W., Ingham, P.W., and Whitfield, T.T. (2009) Expression of patched, prdm1 and engrailed in the lamprey somite reveals conserved responses to Hedgehog signaling. Evolution & development. 11(1):27-40
Hammond, K.L., Loynes, H.E., Mowbray, C., Runke, G., Hammerschmidt, M., Mullins, M.C., Hildreth, V., Chaudhry, B., and Whitfield, T.T. (2009) A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear. PLoS One. 4(2):e4368
Whitfield, T.T., and Hammond, K.L. (2007) Axial patterning in the developing vertebrate inner ear. The International journal of developmental biology. 51(6-7):507-520
Hammond, K.L., and Whitfield, T.T. (2006) The developing lamprey ear closely resembles the zebrafish otic vesicle: otx1 expression can account for all major patterning differences. Development (Cambridge, England). 133(7):1347-1357
Whitfield, T.T., Mburu, P., Hardisty-Hughes, R.E., and Brown, S.D.M. (2005) Models of congenital deafness: Mouse and zebrafish. Drug discovery today. 2(2):85-92
Whitfield, T.T. (2005) Lateral line: precocious phenotypes and planar polarity. Current biology : CB. 15(2):R67-70
Kozlowski, D.J., Whitfield, T.T., Hukriede, N.A., Lam, W.K., and Weinberg, E.S. (2005) The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line. Developmental Biology. 277(1):27-41
Baxendale, S., Davison, C., Muxworthy, C., Wolff, C., Ingham, P.W., and Roy, S. (2004) The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling. Nature Genetics. 36(1):88-93
Hammond, K.L., Loynes, H.E., Folarin, A.A., Smith, J., and Whitfield, T.T. (2003) Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesicle. Development (Cambridge, England). 130(7):1403-1417
Whitfield, T.T. (2002) Zebrafish as a model for hearing and deafness. Journal of neurobiology. 53(2):157-171
Whitfield, T.T., Riley, B.B., Chiang, M.-Y., and Phillips, B. (2002) Development of the zebrafish inner ear. Developmental Dynamics : an official publication of the American Association of Anatomists. 223(4):427-458
Hammond, K.L., Hill, R.E., Whitfield, T.T., and Currie, P.D. (2002) Isolation of three zebrafish dachshund homologues and their expression in sensory organs, the central nervous system and pectoral fin buds. Mechanisms of Development. 112(1-2):183-189
Mowbray, C., Hammerschmidt, M., and Whitfield, T.T. (2001) Expression of BMP signalling pathway members in the developing zebrafish inner ear and lateral line. Mechanisms of Development. 108(1-2):179-184
Whitfield-T. (1999) The New Fish Cook Books: The Zebrafish: Biology (Methods in Cell Biology, Vol. 59), The Zebrafish: Genetics and Genomics (Methods in Cell Biology, Vol. 60) edited by H. William Detrich, III, Monte Westerfield and Leonard I. Zon. Trends in cell biology. 9(11):464-465
Haddon, C., Mowbray, C., Whitfield, T., Jones, D., Gschmeissner, S., and Lewis, J. (1999) Hair cells without supporting cells: further studies in the ear of the zebrafish mind bomb mutant. Journal of neurocytology. 28(10-11):837-850
Parichy, D.M., Rawls, J.F., Pratt, S.J., Whitfield, T.T., and Johnson, S.L. (1999) Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Development (Cambridge, England). 126(15):3425-3436
Whitfield, T., Haddon, C., and Lewis, J. (1997) Intercellular signals and cell-fate choices in the developing inner ear: origins of global and of fine-grained pattern. Seminars in cell & developmental biology. 8(3):239-247
Whitfield, T.T., Granato, M., van Eeden, F.J., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the zebrafish inner ear and lateral line. Development (Cambridge, England). 123:241-254