ZFIN ID: ZDB-LAB-980529-1835
Baker Lab
PI/Director: Baker, Robert
Gilland, Edwin
Co-PI / Senior
Researcher:
Straka, Hans
Contact Person: Baker, Robert
Email: bakerr01@popmail.med.nyu.edu
URL: http://www.med.nyu.edu/Research/R.Baker-res.html
Address: Department of Physiology and Neuroscience New York University School of Medicine 550 First Avenue New York, NY 10016 USA
Country: United States
Phone: (212) 263-5402
Fax: (212) 689-9060
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
CRANIAL MOTOR SYSTEMS IN VERTEBRATES:

Our goals address the evolution, embryology, ethology, and neurophysiology of cranial motor systems in vertebrates. The comparative anatomy and physiology of the visual, vestibular, and oculomotor systems are major fields of interests with experimental emphasis largely directed towards brainstem and cerebellar circuitry underlying eye and head movement. Current research projects center on establishing the intrinsic properties of vestibular, reticular, and cerebellar neurons both in vitro and in vivo with special emphasis on their role in oculomotor performance and motor learning. We use various single-cell microelectrode techniques to correlate excitatory and inhibitory synaptic responses with motor behavior. In complementary work, we address the ontogenetic assembly of cranial sensorimotor systems with contemporary chemical, molecular, and anatomical probes. We are also studying neuroepithelial and mesodermal cell lineage, fate, and tissue development in shark, zebrafish, bird, and mouse embryos. We investigate when and how eye muscles, motoneurons, and vestibular neurons become spatially programmed and functionally specified to produce eye movements. Overall, these experiments are designed to define the processes that coordinate development of sensory/motor networks to provide new insights into genetic blueprints, neuronal specification, and the role of hindbrain segmentation.


LAB MEMBERS
Beck, James Post-Doc Suwa, Hiroshi Post-Doc Debowy, Owen Graduate Student
Green, Andrea Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Miki, S., Urase, K., Baker, R., Hirata, Y. (2020) Velocity storage mechanism drives a cerebellar clock for predictive eye velocity control. Scientific Reports. 10:6944
Glasauer, S., Straka, H. (2017) Postural Control: Learning to Balance Is a Question of Timing. Current biology : CB. 27:R105-R107
Ulrich, F., Grove, C., Torres-Vázquez, J., Baker, R. (2016) Development of functional hindbrain oculomotor circuitry independent of both vascularization and neuronal activity in larval zebrafish. Current Neurobiology. 7:62-73
Rahmat, S., Gilland, E. (2014) Comparative Anatomy of the Carotid-Basilar Arterial Trunk and Hindbrain Penetrating Arteries in Vertebrates. The Open Anatomy Journal. 6:1-26
Ma, L.H., Grove, C.L., Baker, R. (2014) Development of oculomotor circuitry independent of hox3 genes. Nature communications. 5:4221
Straka, H., Baker, R. (2013) Vestibular blueprint in early vertebrates. Frontiers in neural circuits. 7:182
Phillips, C.D., Butler, B., Fondon, J.W., Mantilla-Meluk, H., and Baker, R.J. (2013) Contrasting Evolutionary Dynamics of the Developmental Regulator PAX9, among Bats, with Evidence for a Novel Post-Transcriptional Regulatory Mechanism. PLoS One. 8(2):e57649
Bianco, I.H., Ma, L.H., Schoppik, D., Robson, D.N., Orger, M.B., Beck, J.C., Li, J.M., Schier, A.F., Engert, F., and Baker, R. (2012) The Tangential Nucleus Controls a Gravito-inertial Vestibulo-ocular Reflex. Current biology : CB. 22(14):1285-1295
Ulrich, F., Ma, L.H., Baker, R.G., and Torres-Vazquez, J. (2011) Neurovascular development in the embryonic zebrafish hindbrain. Developmental Biology. 357(1):134-51
Lyons, P.J., Ma, L.H., Baker, R., and Fricker, L.D. (2010) Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. PLoS One. 5(9):e12967
Ma, L.H., Punnamoottil, B., Rinkwitz, S., and Baker, R. (2009) Mosaic hoxb4a neuronal pleiotropism in zebrafish caudal hindbrain. PLoS One. 4(6):e5944
Lambert, F.M., Beck, J.C., Baker, R., and Straka, H. (2008) Semicircular canal size determines the developmental onset of angular vestibuloocular reflexes in larval Xenopus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(32):8086-8095
Hadrys, T., Punnamoottil, B., Pieper, M., Kikuta, H., Pezeron, G., Becker, T.S., Prince, V., Baker, R., and Rinkwitz, S. (2006) Conserved co-regulation and promoter sharing of hoxb3a and hoxb4a in zebrafish. Developmental Biology. 297(1):26-43
Beck, J.C., Gilland, E., Tank, D.W., and Baker, R. (2004) Quantifying the Ontogeny of Optokinetic and Vestibuloocular Behaviors in Zebrafish, Medaka, and Goldfish. Journal of neurophysiology. 92(6):3546-3561
Hadrys, T., Prince, V., Hunter, M., Baker, R., and Rinkwitz, S. (2004) Comparative genomic analysis of vertebrate Hox3 and Hox4 genes. The Journal of experimental zoology. 302(2):147-164
Beck, J.C., Gilland, E., Baker, R., and Tank, D.W. (2004) Instrumentation for measuring oculomotor performance and plasticity in larval organisms. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:385-413
Gilland, E., Baker, R., and Denk, W. (2003) Long duration three-dimensional imaging of calcium waves in zebrafish using multiphoton fluorescence microscopy. The Biological bulletin. 205(2):176-177
Barton, L.M., Gottgens, B., Gering, M., Gilbert, J.G., Grafham, D., Rogers, J., Bentley, D., Patient, R., and Green, A.R. (2001) Regulation of the stem cell leukemia (SCL) gene: a tale of two fishes. Proceedings of the National Academy of Sciences of the United States of America. 98(12):6747-6752
Suwa, H., Saint-Amant, L., Triller, A., Drapeau, P., and Legendre, P. (2001) High-affinity zinc potentiation of inhibitory postsynaptic glycinergic currents in the zebrafish hindbrain. Journal of neurophysiology. 85(2):912-925
Beck, J.C., Murray, J.A., Willows, A.O.D., and Cooper,M.S. (2000) Computer-assisted visualizations of neural networks: expanding the field of view using seamless confocal montaging. Journal of Neuroscience Methods. 98(2):155-163
Durbin, L., Sordino, P., Barrios, A., Gering, M., Thisse, C., Thisse, B., Brennan, C., Green, A., Wilson, S., and Holder, N. (2000) Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish. Development (Cambridge, England). 127(8):1703-1713
Göttgens, B., Barton, L.M., Grafham, D., Vaudin, M., and Green, A.R. (1999) Tdr2, a new zebrafish transposon of the Tc1 family. Gene. 239(2):373-379
Sinclair, A.M., Göttgens, B., Barton, L.M., Stanley, M.L., Pardanaud, L., Klaine, M., Gering, M., Bahn, S., Sanchez, M.-J., Bench, A.J., Fordham, J.L., Bockamp, E.-O., and Green, A.R. (1999) Distinct 5' SCL enhancers direct transcription to developing brain, spinal cord, and endothelium: neural expression is mediated by GATA factor binding sites. Developmental Biology. 209(1):128-142
Gilland, E., Miller, A.L., Karplus, E., Baker, R., Webb, S.E. (1999) Imaging of multicellular large-scale rhythmic calcium waves during zebrafish gastrulation. Proceedings of the National Academy of Sciences of the United States of America. 96:157-161
Lee, K.W., Baker, R., Galione, A., Gilland, E.H., Hanlon, R.T., and Miller, A.L. (1996) Ionophore-induced calcium waves activate unfertilized zebrafish (Danio rerio) eggs. The Biological bulletin. 191(2):265-267
Suwa, H., Gilland, E., and Baker, R. (1996) Segmental organization of vestibular and reticular projections to spinal and oculomotor nuclei in the zebrafish and goldfish. The Biological bulletin. 191(2):257-259
Gilland, E. and Baker, R. (1993) Conservation of neuroepithelial and mesodermal segments in the embryonic vertebrate head. Acta anatomica. 148:110-123