ZFIN Lab: Milano Developmental Biology Lab

ZFIN ID: ZDB-LAB-980227-2

Milano Developmental Biology Lab

PI/Director:	Cotelli, Franco
Contact Person:	Cotelli, Franco
Email:	cotelli@mailserver.unimi.it
URL:	http://www.unimi.it/engl/dipart/biodip/biodipin8.html#sci
Address:	Dipartimento di Biologia Via Celoria 26 20133 Milano ITALY
Country:	Italy
Phone:	39-2-26604470
Fax:	39-2-26604462
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Maternal genes; genes involved in CNS development; analysis of the expression of genes coding for the major egg chorion components.

LAB MEMBERS

Corradi, Nicoletta Graduate Student	Bonsignorio, Daniele Research Staff	Diani, Silvia Research Staff
Lora-Lamia, Carla Research Staff	Piccoli, Silvia Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Bragato, C., Pistocchi, A., Bellipanni, G., Confalonieri, S., Balciunie, J., Monastra, F.M., Carra, S., Vitale, G., Mantecca, P., Cotelli, F., Gaudenzi, G. (2023) Zebrafish dnm1a gene plays a role in the formation of axons and synapses in the nervous tissue. Journal of neuroscience research. 101(8):1345-1359

Fittipaldi, R., Floris, P., Proserpio, V., Cotelli, F., Beltrame, M., Caretti, G. (2021) The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development. Cells. 10(5):

Bragato, C., Carra, S., Blasevich, F., Salerno, F., Brix, A., Bassi, A., Beltrame, M., Cotelli, F., Maggi, L., Mantegazza, R., Mora, M. (2020) Glycogen storage in a zebrafish Pompe disease model is reduced by 3-BrPA treatment. Biochimica et biophysica acta. Molecular basis of disease. 1866(5):165662

Mazzola, M., Deflorian, G., Pezzotta, A., Ferrari, L., Fazio, G., Bresciani, E., Saitta, C., Ferrari, L., Fumagalli, M., Parma, M., Marasca, F., Bodega, B., Riva, P., Cotelli, F., Biondi, A., Marozzi, A., Cazzaniga, G., Pistocchi, A. (2019) NIPBL: a new player in myeloid cells differentiation. Haematologica. 104(7):1332-1341

Fenizia, C., Bottino, C., Corbetta, S., Fittipaldi, R., Floris, P., Gaudenzi, G., Carra, S., Cotelli, F., Vitale, G., Caretti, G. (2018) SMYD3 promotes the epithelial-mesenchymal transition in breast cancer. Nucleic acids research. 47(3):1278-1293

Bottai, D., Spreafico, M., Pistocchi, A., Fazio, G., Adami, R., Grazioli, P., Canu, A., Bragato, C., Rigamonti, S., Parodi, C., Cazzaniga, G., Biondi, A., Cotelli, F., Selicorni, A., Massa, V. (2018) Modeling Cornelia de Lange Syndrome in vitro and in vivo reveals a role for cohesin complex in neuronal survival and differentiation. Human molecular genetics. 28(1):64-73

Carra, S., Sangiorgio, L., Pelucchi, P., Cermenati, S., Mezzelani, A., Martino, V., Palizban, M., Albertini, A., Götte, M., Kehler, J., Deflorian, G., Beltrame, M., Giordano, A., Reinbold, R., Cotelli, F., Bellipanni, G., Zucchi, I. (2018) Zebrafish Tmem230a cooperates with the Delta/Notch signaling pathway to modulate endothelial cell number in angiogenic vessels. Journal of Cellular Physiology. 233(2):1455-1467

Barbieri, A., Carra, S., De Blasio, P., Cotelli, F., Biunno, I. (2017) Sel1l knockdown negatively influences zebrafish embryos endothelium. Journal of Cellular Physiology. 233(7):5396-5404

Celauro, E., Carra, S., Rodriguez, A., Cotelli, F., Dimitri, P. (2017) Functional analysis of the cfdp1 gene in zebrafish provides evidence for its crucial role in craniofacial development and osteogenesis. Experimental cell research. 361(2):236-245

Ceffa, N.G., Cesana, I., Collini, M., D'Alfonso, L., Carra, S., Cotelli, F., Sironi, L., Chirico, G. (2017) Spatiotemporal image correlation analysis of blood flow in branched vessel networks of zebrafish embryos. Journal of Biomedical Optics. 22:1-7

Gaudenzi, G., Albertelli, M., Dicitore, A., Würth, R., Gatto, F., Barbieri, F., Cotelli, F., Florio, T., Ferone, D., Persani, L., Vitale, G. (2017) Patient-derived xenograft in zebrafish embryos: a new platform for translational research in neuroendocrine tumors. Endocrine. 57(2):214-219

Marelli, F., Carra, S., Rurale, G., Cotelli, F., Persani, L. (2017) In vivo functional consequences of human THRA variants expressed in the zebrafish. Thyroid : official journal of the American Thyroid Association. 27(2):279-291

Marquezin, C.A., Ceffa, N.G., Cotelli, F., Collini, M., Sironi, L., Chirico, G. (2016) Image Cross-Correlation Analysis of time varying flows. Analytical chemistry. 88(14):7115-22

Marelli, F., Carra, S., Agostini, M., Cotelli, F., Peeters, R., Chatterjee, K., Persani, L. (2016) Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action. Molecular and Cellular Endocrinology. 424:102-17

Fazio, G., Gaston-Massuet, C., Bettini, L.R., Graziola, F., Scagliotti, V., Cereda, A., Ferrari, L., Mazzola, M., Cazzaniga, G., Giordano, A., Cotelli, F., Bellipanni, G., Biondi, A., Selicorni, A., Pistocchi, A., Massa, V. (2016) CyclinD1 Down Regulation and Increased Apoptosis Are Common Features of Cohesinopathies. Journal of Cellular Physiology. 231(3):613-22

Bragato, C., Gaudenzi, G., Blasevich, F., Pavesi, G., Maggi, L., Giunta, M., Cotelli, F., Mora, M. (2016) Zebrafish as a Model to Investigate Dynamin 2-Related Diseases. Scientific Reports. 6:20466

Colombo, E.A., Carra, S., Fontana, L., Bresciani, E., Cotelli, F., Larizza, L. (2015) A zebrafish model of Poikiloderma with Neutropenia recapitulates the human syndrome hallmarks and traces back neutropenia to the myeloid progenitor. Scientific Reports. 5:15814

Turola, E., Petta, S., Vanni, E., Milosa, F., Valenti, L., Critelli, R., Miele, L., Maccio, L., Calvaruso, V., Fracanzani, A.L., Bianchini, M., Raos, N., Bugianesi, E., Mercorella, S., Di Giovanni, M., Craxì, A., Fargion, S., Grieco, A., Cammà, C., Cotelli, F., Villa, E. (2015) Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis. Disease models & mechanisms. 8(9):1037-46

Noce, I.D., Carra, S., Brusegan, C., Critelli, R., Frassine, A., De Lorenzo, C., Giordano, A., Bellipanni, G., Villa, E., Cotelli, F., Pistocchi, A., Schepis, F. (2015) The Coiled-Coil Domain Containing 80 (ccdc80) Gene Regulates gadd45β2 Expression in the Developing Somites of Zebrafish as a New Player of the Hedgehog Pathway. Journal of Cellular Physiology. 230(4):821-30

Valenti, F., Ibetti, J., Komiya, Y., Baxter, M., Lucchese, A.M., Derstine, L., Covaciu, C., Rizzo, V., Vento, R., Russo, G., Macaluso, M., Cotelli, F., Castiglia, D., Gottardi, C.J., Habas, R., Giordano, A., Bellipanni, G. (2015) The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype. Journal of cellular biochemistry. 116(3):418-30

Fieramonti, L., Foglia, E.A., Malavasi, S., D'Andrea, C., Valentini, G., Cotelli, F., and Bassi, A. (2015) Quantitative measurement of blood velocity in zebrafish with optical vector field tomography. Journal of biophotonics. 8(1-2):52-9

Sironi, L., Bouzin, M., Inverso, D., D'Alfonso, L., Pozzi, P., Cotelli, F., Guidotti, L.G., Iannacone, M., Collini, M., Chirico, G. (2014) In vivo flow mapping in complex vessel networks by single image correlation. Scientific Reports. 4:7341

Ferrari, L., Pistocchi, A., Libera, L., Boari, N., Mortini, P., Bellipanni, G., Giordano, A., Cotelli, F., Riva, P. (2014) FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation. Oncotarget. 5(14):5712-5724

Venturin, M., Carra, S., Gaudenzi, G., Brunelli, S., Gallo, G.R., Moncini, S., Cotelli, F., Riva, P. (2014) ADAP2 in heart development: a candidate gene for the occurrence of cardiovascular malformations in NF1 microdeletion syndrome. Journal of Medical Genetics. 51(7):436-43

Pozzi, P., Sironi, L., D'Alfonso, L., Bouzin, M., Collini, M., Chirico, G., Pallavicini, P., Cotelli, F., Foglia, E.A. (2014) Electron multiplying charge-coupled device-based fluorescence cross-correlation spectroscopy for blood velocimetry on zebrafish embryos. Journal of Biomedical Optics. 19:67007

Vitale, G., Gaudenzi, G., Dicitore, A., Cotelli, F., Ferone, D., and Persani, L. (2014) Zebrafish as an innovative model for neuroendocrine tumors. Endocrine-related cancer. 21(1):R67-83

Pistocchi, A., Fazio, G., Cereda, A., Ferrari, L., Bettini, L.R., Messina, G., Cotelli, F., Biondi, A., Selicorni, A., and Massa, V. (2013) Cornelia de Lange Syndrome: NIPBL haploinsufficiency downregulates canonical Wnt pathway in zebrafish embryos and patients fibroblasts. Cell Death & Disease. 4:e866

Conforti, P., Zuccato, C., Gaudenzi, G., Ieraci, A., Camnasio, S., Buckley, N.J., Mutti, C., Cotelli, F., Contini, A., and Cattaneo, E. (2013) Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models. Journal of neurochemistry. 127(1):22-35

Cermenati, S., Moleri, S., Neyt, C., Bresciani, E., Carra, S., Grassini, D.R., Omini, A., Goi, M., Cotelli, F., François, M., Hogan, B.M., and Beltrame, M. (2013) Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 33(6):1238-47

Pistocchi, A., Gaudenzi, G., Foglia, E., Monteverde, S., Moreno-Fortuny, A., Pianca, A., Cossu, G., Cotelli, F., and Messina, G. (2013) Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution. Development (Cambridge, England). 140(7):1528-1536

Parente, V., Balasso, S., Pompilio, G., Verduci, L., Colombo, G.I., Milano, G., Guerrini, U., Squadroni, L., Cotelli, F., Pozzoli, O., and Capogrossi, M.C. (2013) Hypoxia/Reoxygenation cardiac injury and regeneration in zebrafish adult heart. PLoS One. 8(1):e53748

Sessa, R., Seano, G., di Blasio, L., Gagliardi, P.A., Isella, C., Medico, E., Cotelli, F., Bussolino, F., and Primo, L. (2012) The miR-126 regulates Angiopoietin-1 signaling and vessel maturation by targeting p85beta. Biochimica et biophysica acta. Molecular cell research. 1823(10):1925-1935

Rissone, A., Foglia, E., Sangiorgio, L., Cermenati, S., Nicoli, S., Cimbro, S., Beltrame, M., Bussolino, F., Cotelli, F., and Arese, M. (2012) The Synaptic Proteins beta-Neurexin and Neuroligin Synergize With Extracellular Matrix-Binding Vascular Endothelial Growth Factor A During Zebrafish Vascular Development. Arterioscler. Thromb. Vasc. Biol.. 32(7):1563-1572

Lo Sardo, V., Zuccato, C., Gaudenzi, G., Vitali, B., Ramos, C., Tartari, M., Myre, M.A., Walker, J.A., Pistocchi, A., Conti, L., Valenza, M., Drung, B., Schmidt, B., Gusella, J., Zeitlin, S., Cotelli, F., and Cattaneo, E. (2012) An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin. Nature Neuroscience. 15(5):713-721

Brusegan, C., Pistocchi, A., Frassine, A., Della Noce, I., Schepis, F., and Cotelli, F. (2012) ccdc80-l1 Is Involved in Axon Pathfinding of Zebrafish Motoneurons. PLoS One. 7(2):e31851

Carra, S., Foglia, E., Cermenati, S., Bresciani, E., Giampietro, C., Lora Lamia, C., Dejana, E., Beltrame, M., and Cotelli, F. (2012) Ve-ptp Modulates Vascular Integrity by Promoting Adherens Junction Maturation. PLoS One. 7(12):e51245

Fieramonti, L., Bassi, A., Foglia, E.A., Pistocchi, A., D'Andrea, C., Valentini, G., Cubeddu, R., De Silvestri, S., Cerullo, G., and Cotelli, F. (2012) Time-gated optical projection tomography allows visualization of adult zebrafish internal structures. PLoS One. 7(11):e50744

Pozzoli, O., Vella, P., Iaffaldano, G., Parente, V., Devanna, P., Lacovich, M., Lamia, C.L., Fascio, U., Longoni, D., Cotelli, F., Capogrossi, M.C., and Pesce, M. (2011) Endothelial Fate and Angiogenic Properties of Human CD34+ Progenitor Cells in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 31(7):1589-97

Moleri, S., Cappellano, G., Gaudenzi, G., Cermenati, S., Cotelli, F., Horner, D.S., and Beltrame, M. (2011) The HMGB protein gene family in zebrafish: Evolution and embryonic expression patterns. Gene expression patterns : GEP. 11(1-2):3-11

Bresciani, E., Confalonieri, S., Cermenati, S., Cimbro, S., Foglia, E., Beltrame, M., Di Fiore, P.P., and Cotelli, F. (2010) Zebrafish numb and numblike are involved in primitive erythrocyte differentiation. PLoS One. 5(12):e14296

Geudens, I., Herpers, R., Hermans, K., Segura, I., Ruiz de Almodovar, C., Bussmann, J., De Smet, F., Vandevelde, W., Hogan, B.M., Siekmann, A., Claes, F., Moore, J.C., Pistocchi, A.S., Loges, S., Mazzone, M., Mariggi, G., Bruyere, F., Cotelli, F., Kerjaschki, D., Noel, A., Foidart, J.M., Gerhardt, H., Ny, A., Langenberg, T., Lawson, N.D., Duckers, H.J., Schulte-Merker, S., Carmeliet, P., and Dewerchin, M. (2010) Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler. Thromb. Vasc. Biol.. 30(9):1695-1702

Zizioli, D., Forlanelli, E., Guarienti, M., Nicoli, S., Fanzani, A., Bresciani, R., Borsani, G., Preti, A., Cotelli, F., and Schu, P. (2010) Characterization of the AP-1 mu1A and mu1B adaptins in zebrafish (Danio rerio). Developmental Dynamics : an official publication of the American Association of Anatomists. 239(9):2404-2412

Donnini, S., Solito, R., Cetti, E., Corti, F., Giachetti, A., Carra, S., Beltrame, M., Cotelli, F., and Ziche, M. (2010) A{beta} peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(7):2385-2395

Rissone, A., Sangiorgio, L., Monopoli, M., Beltrame, M., Zucchi, I., Bussolino, F., Arese, M., and Cotelli, F. (2010) Characterization of the neuroligin gene family expression and evolution in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(2):688-702

Pistocchi, A., Feijoo, C.G., Cabrera, P., Villablanca, E.J., Allende, M.L., and Cotelli, F. (2009) The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line. BMC Developmental Biology. 9:58

Montero-Balaguer, M., Swirsding, K., Orsenigo, F., Cotelli, F., Mione, M., and Dejana, E. (2009) Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos. PLoS One. 4(6):e5772

Schnapp, E., Pistocchi, A.S., Karampetsou, E., Foglia, E., Lamia, C.L., Cotelli, F., and Cossu, G. (2009) Induced early expression of mrf4 but not myog rescues myogenesis in the myod/myf5 double-morphant zebrafish embryo. Journal of Cell Science. 122(Pt 4):481-488

Pistocchi, A., Bartesaghi, S., Cotelli, F., and Del Giacco, L. (2008) Identification and expression pattern of zebrafish prox2 during embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3916-3920

Pistocchi, A., Gaudenzi, G., Carra, S., Bresciani, E., Del Giacco, L., and Cotelli, F. (2008) Crucial role of zebrafish prox1 in hypothalamic catecholaminergic neurons development. BMC Developmental Biology. 8:27

Cermenati, S., Moleri, S., Cimbro, S., Corti, P., Del Giacco, L., Amodeo, R., Dejana, E., Koopman, P., Cotelli, F., and Beltrame, M. (2008) Sox18 and Sox7 play redundant roles in vascular development. Blood. 111(5):2657-2666

Villablanca, E.J., Pistocchi, A., Court, F.A., Cotelli, F., Bordignon, C., Allende, M.L., Traversari, C., and Russo, V. (2007) Abrogation of Prostaglandin E2/EP4 Signaling Impairs the Development of rag1+ Lymphoid Precursors in the Thymus of Zebrafish Embryos. Journal of immunology (Baltimore, Md. : 1950). 179(1):357-364

Nicoli, S., Ribatti, D., Cotelli, F., and Presta, M. (2007) Mammalian tumor xenografts induce neovascularization in zebrafish embryos. Cancer research. 67(7):2927-2931

Rissone, A., Monopoli, M., Beltrame, M., Bussolino, F., Cotelli, F., and Arese, M. (2007) Comparative Genome Analysis of the Neurexin Gene Family in Danio rerio: Insights into Their Functions and Evolution. Mol. Biol. Evol.. 24(1):236-252

Del Giacco, L., Sordino, P., Pistocchi, A., Andreakis, N., Tarallo, R., Di Benedetto, B., and Cotelli, F. (2006) Differential regulation of the zebrafish orthopedia1 gene during fate determination of diencephalic neurons. BMC Developmental Biology. 6:50

Belleri, M., Ribatti, D., Nicoli, S., Cotelli, F., Forti, L., Vannini, V., Stivala, L.A., and Presta, M. (2005) Antiangiogenic and Vascular-Targeting Activity of the Microtubule-Destabilizing trans-Resveratrol Derivative 3,5,4′-Trimethoxystilbene. Molecular pharmacology. 67(5):1451-1459

Nicoli, S., Gilardelli, C.N., Pozzoli, O., Presta, M., and Cotelli, F. (2005) Regulated expression pattern of gremlin during zebrafish development. Gene expression patterns : GEP. 5(4):539-544

Pozzoli, O., Gilardelli, C.N., Sordino, P., Doniselli, S., Lamia, C.L., and Cotelli, F. (2004) Identification and expression pattern of mago nashi during zebrafish development. Gene expression patterns : GEP. 5(2):265-272

Gilardelli, C.N., Pozzoli, O., Sordino, P., Matassi, G., and Cotelli, F. (2004) Functional and hierarchical interactions among zebrafish vox/vent homeobox genes. Developmental Dynamics : an official publication of the American Association of Anatomists. 230(3):494-508

Argenton, F., Giudici, S., Deflorian, G., Cimbro, S., Cotelli, F., and Beltrame, M. (2004) Ectopic expression and knockdown of a zebrafish sox21 reveal its role as a transcriptional repressor in early development. Mechanisms of Development. 121(2):131-142

Biava, P.M., Bonsignorio, D., and Hoxha, M. (2001) Cell proliferation curves of different human tumor lines after in vitro treatment with zebrafish embryonic extracts. J. Tumor Mark. Oncol.. 16(3):195-202

Biava, P., Monguzzi, A., Bonsignorio, D., Frosi, A., Sell, S., and Klavins, J.V. (2001) Xenopus laevis embryos share antigens with zebrafish embryos and with human malignant neoplasms. J. Tumor Mark. Oncol.. 16(3):203-206

Boggetti, B., Argenton, F., Haffter, P., Bianchi, M.E., Cotelli, F., and Beltrame, M. (2000) Cloning and expression pattern of a zebrafish homolog of forkhead activin signal transducer (FAST), a transcription factor mediating Nodal-related signals. Mechanisms of Development. 99(1-2):187-190

Del Giacco, L., Diani, S., and Cotelli, F. (2000) Identification and spatial distribution of the mRNA encoding an egg envelope component of the Cyprinid zebrafish, Danio rerio, homologous to the mammalian ZP3(ZPC). Development genes and evolution. 210(1):41-46

Rimini, R., Beltrame, M., Argenton, F., Szymczak, D., Cotelli, F., and Bianchi, M.E. (1999) Expression patterns of zebrafish sox11A, sox11B and sox21. Mechanisms of Development. 89(1-2):167-171

Barabino, S.M.L., Spada, F., Cotelli, F., and Boncinelli, E. (1997) Inactivation of the zebrafish homologue of Chx10 by antisense oligonucleotides causes eye malformations similar to the ocular retardation phenotype. Mechanisms of Development. 63(2):133-143

Bonsignorio, D., Perego, L., Del Giacco, L., and Cotelli, F. (1996) Structure and macromolecular composition of the zebrafish egg chorion. Zygote (Cambridge, England). 4(2):101-108

Mercier, P., Simeone, A., Cotelli, F., and Boncinelli, E. (1995) Expression pattern of two otx genes suggests a role in specifying anterior body structures in zebrafish. The International journal of developmental biology. 39:559-573