ZFIN Lab: Genetics of Neural Development

ZFIN ID: ZDB-LAB-980220-5

Genetics of Neural Development

PI/Director:	Dambly-Chaudière, Christine Ghysen, Alain
Contact Person:	Ghysen, Alain
Email:	alain.ghysen@univ-montp2.fr
URL:	http://www.univ-montp2.fr/~neurodvpmt/
Address:	INSERM E343 CC103 Universite Montpellier II Place Eugène Bataillon 34095 Montpellier Cedex 05 FRANCE
Country:	France
Phone:	33-4-67-14-32-53
Fax:	33-4-67-14-39-28
Line Designation:	ump

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 3 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Cubedo, Nicolas

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Mezghrani, B., Ali, L.M.A., Cubedo, N., Rossel, M., Hesemann, P., Durand, J.O., Bettache, N. (2023) Periodic Mesoporous Ionosilica Nanoparticles for Dual Cancer Therapy: Two-Photon Excitation siRNA Gene Silencing in Cells and Photodynamic Therapy in Zebrafish Embryos. International journal of pharmaceutics. 641:123083

Vaché, C., Cubedo, N., Mansard, L., Sarniguet, J., Baux, D., Faugère, V., Baudoin, C., Moclyn, M., Touraine, R., Lina-Granade, G., Cossée, M., Bergougnoux, A., Kalatzis, V., Rossel, M., Roux, A.F. (2023) Identification and in vivo functional investigation of a HOMER2 nonstop variant causing hearing loss. European journal of human genetics : EJHG. 31(7):834-840

Lasbleiz, C., Peyrel, A., Tarot, P., Sarniguet, J., Crouzier, L., Cubedo, N., Delprat, B., Rossel, M., Maurice, T., Liévens, J.C. (2022) Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling. Redox Biology. 58:102542102542

Crouzier, L., Richard, E.M., Diez, C., Denus, M., Peyrel, A., Alzaeem, H., Cubedo, N., Delaunay, T., Maurice, T., Delprat, B. (2022) NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome. Molecular therapy. Methods & clinical development. 27:295-308

Nasri, A., Lafon, P.A., Mezni, A., Clair, P., Cubedo, N., Mahmoudi, E., Beyrem, H., Rossel, M., Perrier, V. (2022) Developmental exposure to the A6-pesticide causes changes in tyrosine hydroxylase gene expression, neurochemistry, and locomotors behavior in larval zebrafish. Toxicology mechanisms and methods. 32(8):569-579

Crouzier, L., Richard, E.M., Diez, C., Alzaeem, H., Denus, M., Cubedo, N., Delaunay, T., Glendenning, E., Baxendale, S., Liévens, J.C., Whitfield, T.T., Maurice, T., Delprat, B. (2022) Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines. Human molecular genetics. 31(16):2711-2727

Crouzier, L., Danese, A., Yasui, Y., Richard, E.M., Liévens, J.C., Patergnani, S., Couly, S., Diez, C., Denus, M., Cubedo, N., Rossel, M., Thiry, M., Su, T.P., Pinton, P., Maurice, T., Delprat, B. (2022) Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models. Science Translational Medicine. 14:eabh3763

Cahu, M., Ali, L.M.A., Sene, S., Long, J., Camerel, F., Ciancone, M., Salles, F., Chopineau, J., Devoisselle, J.M., Felix, G., Cubedo, N., Rossel, M., Guari, Y., Bettache, N., Larionova, J., Gary-Bobo, M. (2021) A rational study of the influence of Mn²⁺-insertion in Prussian blue nanoparticles on their photothermal properties. Journal of materials chemistry. B. 9:9670-9683

Crouzier, L., Denus, M., Richard, E.M., Tavernier, A., Diez, C., Cubedo, N., Maurice, T., Delprat, B. (2021) Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish. International Journal of Molecular Sciences. 22(20):

Crouzier, L., Diez, C., Richard, E.M., Cubedo, N., Barbereau, C., Rossel, M., Delaunay, T., Maurice, T., Delprat, B. (2021) Loss of Pde6a Induces Rod Outer Segment Shrinkage and Visual Alterations in pde6a^Q70X Mutant Zebrafish, a Relevant Model of Retinal Dystrophy. Frontiers in cell and developmental biology. 9:675517

Barbereau, C., Cubedo, N., Maurice, T., Rossel, M. (2021) Zebrafish Models to Study New Pathways in Tauopathies. International Journal of Molecular Sciences. 22(9):

Nasri, A., Mezni, A., Lafon, P.A., Wahbi, A., Cubedo, N., Clair, P., Harrath, A.H., Beyrem, H., Rossel, M., Perrier, V. (2021) Ethinylestradiol (EE2) residues from birth control pills impair nervous system development and swimming behavior of zebrafish larvae. The Science of the total environment. 770:145272

Barbereau, C., Yehya, A., Silhol, M., Cubedo, N., Verdier, J.M., Maurice, T., Rossel, M. (2020) Neuroprotective Brain-Derived Neurotrophic Factor signaling in the TAU-P301L tauopathy zebrafish model. Pharmacological research. 158:104865

Brodoline, A., Rawat, N., Alexandre, D., Cubedo, N., Gross, M. (2019) 4D compressive sensing holographic imaging of small moving objects with multiple illuminations. Applied optics. 58:G127-G134

Moussaed, M., Huc-Brandt, S., Cubedo, N., Silhol, M., Murat, S., Lebart, M.C., Kovacs, G., Verdier, J.M., Trousse, F., Rossel, M., Marcilhac, A. (2018) Regenerating islet-derived 1α (REG-1α) protein increases tau phosphorylation in cell and animal models of tauopathies. Neurobiology of disease. 119:136-148

Nasri, A., Valverde, A.J., Roche, D.B., Desrumaux, C., Clair, P., Beyrem, H., Chaloin, L., Ghysen, A., Perrier, V. (2016) Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations. International Journal of Molecular Sciences. 17(12)

Ghysen, A., Dambly-Chaudière, C. (2016) Development vs. behavior: a role for neural adaptation in evolution?. The International journal of developmental biology. 60:77-84

Huc-Brandt, S., Hieu, N., Imberdis, T., Cubedo, N., Silhol, M., Leighton, P.L., Domaschke, T., Allison, W.T., Perrier, V., Rossel, M. (2014) Zebrafish Prion Protein PrP2 Controls Collective Migration Process during Lateral Line Sensory System Development. PLoS One. 9:e113331

Graciarena, M., Dambly-Chaudière, C., and Ghysen, A. (2014) Dynamics of axonal regeneration in adult and aging zebrafish reveal the promoting effect of a first lesion. Proceedings of the National Academy of Sciences of the United States of America. 111(4):1610-1615

Schuster, K., and Ghysen, A. (2013) Making mosaic fish primordia by focal electroporation. Cold Spring Harbor protocols. 2013(12):pdb.prot079442

Schuster, K., and Ghysen, A. (2013) Labeling hair cells and afferent neurons in the posterior lateral-line system of zebrafish. Cold Spring Harbor protocols. 2013(12):pdb.prot079467

Schuster, K., and Ghysen, A. (2013) Labeling second-order sensory neurons in the posterior lateral-line system of zebrafish. Cold Spring Harbor protocols. 2013(12):pdb.prot079475

Schuster, K., and Ghysen, A. (2013) Labeling defined cells or subsets of cells in zebrafish by kaede photoconversion. Cold Spring Harbor protocols. 2013(11):13440-8

Wada, H., Ghysen, A., Asakawa, K., Abe, G., Ishitani, T., and Kawakami, K. (2013) Wnt/Dkk Negative Feedback Regulates Sensory Organ Size in Zebrafish. Current biology : CB. 23(16):1559-65

Wada, H., Dambly-Chaudière, C., Kawakami, K., and Ghysen, A. (2013) Innervation is required for sense organ development in the lateral line system of adult zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 110(14):5659-5664

Ghysen, A., Dambly-Chaudière, C., Coves, D., de la Gandara, F., and Ortega, A. (2012) Developmental origin of a major difference in sensory patterning between zebrafish and bluefin tuna. Evolution & development. 14(2):204-211

Gamba, L., Cubedo, N., Lutfalla, G., Ghysen, A., and Dambly-Chaudiere, C. (2010) Lef1 controls patterning and proliferation in the posterior lateral line system of zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(12):3163-3171

Schuster, K., Dambly-Chaudière, C., and Ghysen, A. (2010) Glial cell line-derived neurotrophic factor defines the path of developing and regenerating axons in the lateral line system of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 107(45):19531-19536

Sarrazin, A.F., Nuñez, V.A., Sapède, D., Tassin, V., Dambly-Chaudière, C., and Ghysen, A. (2010) Origin and early development of the posterior lateral line system of zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(24):8234-8244

Wada, H., Ghysen, A., Satou, C., Higashijima, S.I., Kawakami, K., Hamaguchi, S., and Sakaizumi, M. (2010) Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish. Developmental Biology. 340(2):583-594

Gamba, L., Cubedo, N., Ghysen, A., Lutfalla, G., and Dambly-Chaudière, C. (2010) Estrogen receptor ESR1 controls cell migration by repressing chemokine receptor CXCR4 in the zebrafish posterior lateral line system. Proceedings of the National Academy of Sciences of the United States of America. 107(14):6358-6363

Ghysen, A., Schuster, K., Coves, D., de la Gandara, F., Papandroulakis, N., and Ortega, A. (2010) Development of the posterior lateral line system in Thunnus thynnus, the atlantic blue-fin tuna, and in its close relative Sarda sarda. The International journal of developmental biology. 54(8-9):1317-1322

Nuñez, V.A., Sarrazin, A.F., Cubedo, N., Allende, M.L., Dambly-Chaudière, C., and Ghysen, A. (2009) Postembryonic development of the posterior lateral line in the zebrafish. Evolution & development. 11(4):391-404

Laguerre, L., Ghysen, A., and Dambly-Chaudière, C. (2009) Mitotic patterns in the migrating lateral line cells of zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(5):1042-1051

Cubedo, N., Cerdan, E., Sapede, D., and Rossel, M. (2009) CXCR4 and CXCR7 cooperate during tangential migration of facial motoneurons. Molecular and cellular neurosciences. 40(4):474-484

Ghysen, A., and Dambly-Chaudière, C. (2007) The lateral line microcosmos. Genes & Development. 21(17):2118-2130

Ghysen, A., Dambly-Chaudiere, C., and Raible, D. (2007) Making sense of zebrafish neural development in the Minervois. Neural Development. 2(1):15

Dambly-Chaudière, C., Cubedo, N., and Ghysen, A. (2007) Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1. BMC Developmental Biology. 7:23

Fame, R.M., Brajon, C., and Ghysen, A. (2006) Second-order projection from the posterior lateral line in the early zebrafish brain. Neural Development. 1:4

Villablanca, E.J., Renucci, A., Sapede, D., Lec, V., Soubiran, F., Sandoval, P.C., Dambly-Chaudiere, C., Ghysen, A., and Allende, M.L. (2006) Control of cell migration in the zebrafish lateral line: Implication of the gene "Tumour-Associated Calcium Signal Transducer," tacstd. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(6):1578-1588

Laguerre, L., Soubiran, F., Ghysen, A., Konig, N., and Dambly-Chaudiere, C. (2005) Cell proliferation in the developing lateral line system of zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(2):466-472

Sapede, D., Rossel, M., Dambly-Chaudiere, C., and Ghysen, A. (2005) Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons. Proceedings of the National Academy of Sciences of the United States of America. 102(5):1714-1718

Pichon, F., and Ghysen, A. (2004) Evolution of posterior lateral line development in fish and amphibians. Evolution & development. 6(3):187-193

Ghysen, A., and Dambly-Chaudiere, C. (2004) Development of the zebrafish lateral line. Current opinion in neurobiology. 14(1):67-73

Ghysen, A. and Dambly-Chaudiere, C. (2003) The development of the nervous system: from fly to fish, from fish to man. Med. Sci.. 19(5):575-581

David, N.B., Sapede, D., Saint-Etienne, L., Thisse, C., Thisse, B., Dambly-Chaudiere, C., Rosa, F.M., and Ghysen, A. (2002) Molecular basis of cell migration in the fish lateral line: role of the chemokine receptor CXCR4 and of its ligand, SDF1. Proceedings of the National Academy of Sciences of the United States of America. 99(25):16297-16302

Sapède, D., Gompel, N., Dambly-Chaudière, C., and Ghysen, A. (2002) Cell migration in the postembryonic development of the fish lateral line. Development (Cambridge, England). 129:605-615

Gompel, N., Cubedo, N., Thisse, C., Thisse, B., Dambly-Chaudiere, C., and Ghysen, A. (2001) Pattern formation in the lateral line of zebrafish. Mechanisms of Development. 105(1-2):69-77

Bricaud, O., Chaar, V., Dambly-Chaudiere, C., and Ghysen, A. (2001) Early efferent innervation of the zebrafish lateral line. The Journal of comparative neurology. 434(3):253-261

Gompel, N., Dambly-Chaudière, C., and Ghysen, A. (2001) Neuronal differences prefigure somatotopy in the zebrafish lateral line. Development (Cambridge, England). 128(3):387-393

Alexandre, D. and Ghysen, A. (1999) Somatotopy of the lateral line projection in larval zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 96(13):7558-7562