ZFIN ID: ZDB-LAB-980204-1
Linney Lab
PI/Director: Linney, Elwood
Contact Person: Linney, Elwood
Email: elwood.linney@duke.edu
URL: http://glowfish.mc.duke.edu/
Address: Laboratory of Molecular Development Department of Molecular Genetics and Microbiology Duke University Medical Center Box 3020 Durham, NC 27710 USA
Country: United States
Phone: (919) 684-6744
Fax: (919) 684-8735
Line Designation: ld

Show all 1 genomic features

We are studying retinoic acid and estrogen signaling during embryogenesis in zebrafish. We are using yeast two-hybrid selection, retroviral vectors, mutant gfp reporters and other fluorescent reagents to record in 2d, 3d, and 4d gene expression during embryogenesis.

Perz-Edwards, Alyssa Graduate Student Donerly, Sue Research Staff Hardison, Nancy Research Staff

Aluru, N., Kuo, E., Helfrich, L.W., Karchner, S.I., Linney, E.A., Pais, J.E., Franks, D.G. (2015) Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters DNA methyltransferase (dnmt) expression in zebrafish (Danio rerio). Toxicology and applied pharmacology. 284(2):142-51
Hahn, M.E., McArthur, A.G., Karchner, S.I., Franks, D.G., Jenny, M.J., Timme-Laragy, A.R., Stegeman, J.J., Woodin, B.R., Cipriano, M.J., Linney, E. (2014) The Transcriptional Response to Oxidative Stress during Vertebrate Development: Effects of tert-Butylhydroquinone and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. PLoS One. 9:e113158
Roy, N.M., Arpie, B., Lugo, J., Linney, E., Levin, E.D., and Cerutti, D. (2012) Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. Neurotoxicology and teratology. 34(6):587-591
Levin, E.D., Sledge, D., Roach, S., Petro, A., Donerly, S., and Linney, E. (2011) Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicology and teratology. 33(6):668-73
Linney, E., Donerly, S., Mackey, L., and Dobbs-McAuliffe, B. (2011) The negative side of retinoic acid receptors. Neurotoxicology and teratology. 33(6):631-40
Sledge, D., Yen, J., Morton, T., Dishaw, L., Petro, A., Donerly, S., Linney, E., and Levin, E.D. (2011) Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicology and teratology. 33(6):742-51
Yen, J., Donerly, S., Levin, E.D., and Linney, E.A. (2011) Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicology and teratology. 33(6):735-41
Linney, E., Perz-Edwards, A., and Kelley, B. (2011) Identification and characterization of a functional zebrafish smrt corepressor (ncor2). Gene. 486(1-2):31-6
Aschner, M., Levin, E.D., Suñol, C., Olopade, J.O., Helmcke, K.J., Avila, D.S., Sledge, D., Ali, R.H., Upchurch, L., Donerly, S., Linney, E., Forsby, A., Ponnoru, P., and Connor, J.R. (2010) Gene-Environment Interactions: Neurodegeneration in Non-Mammals and Mammals. Neurotoxicology. 31(5):582-588
Alexeyenko, A., Wassenberg, D.M., Lobenhofer, E.K., Yen, J., Linney, E., Sonnhammer, E.L., and Meyer, J.N. (2010) Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. PLoS One. 5(5):e10465
Powers, C.M., Yen, J., Linney, E.A., Seidler, F.J., and Slotkin, T.A. (2010) Silver exposure in developing Zebrafish (Danio rerio): Persistent effects on larval behavior and survival. Neurotoxicology and teratology. 32(3):391-397
Eddins, D., Cerutti, D., Williams, P., Linney, E., and Levin, E.D. (2010) Zebrafish Provide a Sensitive Model of Persisting Neurobehavioral Effects of Developmental Chlorpyrifos Exposure: Comparison with Nicotine and Pilocarpine Effects and Relationship to Dopamine Deficits. Neurotoxicology and teratology. 32(1):99-108
Timme-Laragy, A.R., Van Tiem, L.A., Linney, E.A., and Di Giulio, R.T. (2009) Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 109(2):217-227
Hu, P., Tian, M., Bao, J., Xing, G., Gu, X., Gao, X., Linney, E., and Zhao, Q. (2008) Retinoid regulation of the zebrafish cyp26a1 promoter. Developmental dynamics : an official publication of the American Association of Anatomists. 237(12):3798-3808
Malone, M.H., Sciaky, N., Stalheim, L., Hahn, K.M., Linney, E., and Johnson, G.L. (2007) Laser-scanning velocimetry: A confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. BMC Biotechnology. 7(1):40
Kim, M.J., Liu, I.H., Song, Y., Lee, J.A., Halfter, W., Balice-Gordon, R.J., Linney, E., and Cole, G.J. (2007) Agrin is Required for Posterior Development and Motor Axon Outgrowth and Branching in Embryonic Zebrafish. Glycobiology. 17(2):231-247
Lassiter, C.S., and Linney, E. (2007) Embryonic Expression And Steroid Regulation of Brain Aromatase cyp19a1b in Zebrafish (Danio Rerio). Zebrafish. 4(1):49-58
Zhao, Q., Dobbs-McAuliffe, B., and Linney, E. (2005) Expression of cyp26b1 during zebrafish early development. Gene expression patterns : GEP. 5(3):363-369
Levin, E.D., Swain, H.A., Donerly, S., and Linney, E. (2004) Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior. Neurotoxicology and teratology. 26(6):719-723
Linney, E., Upchurch, L., and Donerly, S. (2004) Zebrafish as a neurotoxicological model. Neurotoxicology and teratology. 26(6):709-718
Linney, E., Dobbs-McAuliffe, B., Sajadi, H., and Malek, R.L. (2004) Microarray gene expression profiling during the segmentation phase of zebrafish development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 138(3):351-362
Dobbs-McAuliffe, B., Zhao, Q., and Linney, E. (2004) Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. Mechanisms of Development. 121(4):339-350
Linney, E., and Udvadia, A.J. (2004) Construction and detection of fluorescent, germline transgenic zebrafish. Methods in molecular biology (Clifton, N.J.). 254:271-288
Udvadia, A.J. and Linney, E. (2003) Windows into development: historic, current, and future perspectives on transgenic zebrafish. Developmental Biology. 256(1):1-17
Levin, E.D., Chrysanthis, E., Yacisin, K., and Linney, E. (2003) Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicology and teratology. 25(1):51-57
Lassiter, C.S., Kelley, B., and Linney, E. (2002) Genomic structure and embryonic expression of estrogen receptor beta a (ERbetaa) in zebrafish (Danio rerio). Gene. 299(1-2):141-151
Perz-Edwards, A., Hardison, N.L., and Linney, E. (2001) Retinoic acid-mediated gene expression in transgenic reporter zebrafish. Developmental Biology. 229(1):89-101
Perz-Edwards, A.K. (2001) Gene activation and repression by retinoid receptors during vertebrate embryogenesis. Ph.D. Thesis.
Linney, E., Hardison, N.L., Lonze, B.E., Lyons, S., and DiNapoli, L. (1999) Transgene expression in zebrafish: a comparison of retroviral-vector and DNA-injection approaches. Developmental Biology. 213(1):207-216