ZFIN ID: ZDB-LAB-971016-2
The Zon Lab
PI/Director: Zon, Leonard I.
Contact Person: diCicco, Hannah
Email: hdicicco@enders.tch.harvard.edu
URL: http://zon.tchlab.org
Address: Howard Hughes Medical Institute Division of Hematology/Oncology Children's Hospital Enders 7 300 Longwood Avenue Boston, MA 02115 USA
Country: United States
Phone: (617) 919-2069
Fax: 617-730-0222
Line Designation: cz


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show first 50 of 88 genomic features


STATEMENT OF RESEARCH INTERESTS
During vertebrate development, ventral mesoderm is induced and specified to form hematopoietic stem cells and later, proliferation and differentiation of the progenitor populations occurs. We executed an expression cloning screen for stem cell inducers of Xenopus by creating a cDNA library just prior to initiation of GATA-1 transcription. This library was segregated into pools, which were injected into embryos at the 1 cell stage. 48 hours later, embryos were scored for excessive blood formation. One pool produced the gene PAX-like Mix.1, which is a homeobox gene that is activin and BMP4 inducible. Mix.1 can transform dorsal mesoderm, which normally would become muscle, into blood. In the zebrafish, we have utilized genetics to define genes that are required for hematopoietic stem cell induction. We have 20 complementation groups of mutants that encompass 4 with stem cell defects, 8 with proliferation problems, 6 with globin expression defects, and 2 with porphyria. We are in the process of position cloning genes in the zebrafish that are represented by these mutants. Isolation of these genes should improve our understanding of hematopoietic stem cell induction during vertebrate embryogenesis.


LAB MEMBERS
Zhou, Yi Post-Doc diCicco, Hannah Administrative Staff Albacker, Colleen
Al-Green, Nicole Bai, Xiaoying Barut, Bruce
Beltre, Rosanna Bourque, Caitlin Boyer, Leah
Burke, Christopher Chatterton, Maria Chaudhry, Wahaj
Datta, Sumon de Jong, Jill DiBiase, Anthony
Dovey, Michael Hsia, Nelson Huang, Emily
Keefe, Matthew Kent, Christine Le, Xiuning
LeBlanc, Jocelyn Lord, Allegra McCollum, Artie
Opara, Praise Paffett-Lugassy, Noelle Pfaff, Kathleen
Rooke, Rebecca Schlaeger, Thorsten Sessa, Anna
Song, Anhua Storer, Narie Taylor, Alison
van Rooijen, Ellen Weber, Gerhard Zhang, Li-Kun


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Bornhorst, D., Gheller, B., Zon, L.I. (2024) Colorimetric Barcoding to Track, Isolate, and Analyze Hematopoietic Stem Cell Clones. Methods in molecular biology (Clifton, N.J.). 2707:265277265-277
Yang, R.M., Song, S.Y., Wu, F.Y., Yang, R.F., Shen, Y.T., Tu, P.H., Wang, Z., Zhang, J.X., Cheng, F., Gao, G.Q., Liang, J., Guo, M.M., Yang, L., Zhou, Y., Zhao, S.X., Zhan, M., Song, H.D. (2023) Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB. Nature communications. 14:80828082
Song, J., Gooding, A.R., Hemphill, W.O., Love, B.D., Robertson, A., Yao, L., Zon, L.I., North, T.E., Kasinath, V., Cech, T.R. (2023) Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science (New York, N.Y.). 381:133113371331-1337
Oksuz, O., Henninger, J.E., Warneford-Thomson, R., Zheng, M.M., Erb, H., Vancura, A., Overholt, K.J., Hawken, S.W., Banani, S.F., Lauman, R., Reich, L.N., Robertson, A.L., Hannett, N.M., Lee, T.I., Zon, L.I., Bonasio, R., Young, R.A. (2023) Transcription factors interact with RNA to regulate genes. Molecular Cell. 83(14):2449-2463.e13
Binder, V., Li, W., Faisal, M., Oyman, K., Calkins, D.L., Shaffer, J., Teets, E.M., Sher, S., Magnotte, A., Belardo, A., Deruelle, W., Gregory, T.C., Orwick, S., Hagedorn, E.J., Perlin, J.R., Avagyan, S., Lichtig, A., Barrett, F., Ammerman, M., Yang, S., Zhou, Y., Carson, W.E., Shive, H.R., Blachly, J.S., Lapalombella, R., Zon, L.I., Blaser, B.W. (2023) Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Reports. 42:112528112528
McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O. (2023) Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Scientific Reports. 13:77777777
Hagedorn, E.J., Perlin, J.R., Freeman, R.J., Wattrus, S.J., Han, T., Mao, C., Kim, J.W., Fernández-Maestre, I., Daily, M.L., D'Amato, C., Fairchild, M.J., Riquelme, R., Li, B., Ragoonanan, D.A.V.E., Enkhbayar, K., Henault, E.L., Wang, H.G., Redfield, S.E., Collins, S.H., Lichtig, A., Yang, S., Zhou, Y., Kunar, B., Gomez-Salinero, J.M., Dinh, T.T., Pan, J., Holler, K., Feldman, H.A., Butcher, E.C., van Oudenaarden, A., Rafii, S., Junker, J.P., Zon, L.I. (2023) Transcription factor induction of vascular blood stem cell niches in vivo. Developmental Cell. 58(12):1037-1051.e4
Insco, M.L., Abraham, B.J., Dubbury, S.J., Kaltheuner, I.H., Dust, S., Wu, C., Chen, K.Y., Liu, D., Bellaousov, S., Cox, A.M., Martin, B.J.E., Zhang, T., Ludwig, C.G., Fabo, T., Modhurima, R., Esgdaille, D.E., Henriques, T., Brown, K.M., Chanock, S.J., Geyer, M., Adelman, K., Sharp, P.A., Young, R.A., Boutz, P.L., Zon, L.I. (2023) Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.). 380:eabn7625eabn7625
Tavakoli, S., Garcia, V., Gähwiler, E., Adatto, I., Rangan, A., Messemer, K.A., Kakhki, S.A., Yang, S., Chan, V.S., Manning, M.E., Fotowat, H., Zhou, Y., Wagers, A.J., Zon, L.I. (2023) Transplantation-based screen identifies inducers of muscle progenitor cell engraftment across vertebrate species. Cell Reports. 42:112365112365
LeBleu, V.S., Dai, J., Tsutakawa, S., MacDonald, B.A., Alge, J.L., Sund, M., Xie, L., Sugimoto, H., Tainer, J., Zon, L.I., Kalluri, R. (2023) Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(7):1046-1060
Adatto, I., Lawrence, C., Krug, L., Zon, L.I. (2022) The effects of intensive feeding on reproductive performance in laboratory zebrafish (Danio rerio). PLoS One. 17:e0278302e0278302
Ablain, J., Al Mahi, A., Rothschild, H., Prasad, M., Aires, S., Yang, S., Dokukin, M.E., Xu, S., Dang, M., Sokolov, I., Lian, C.G., Zon, L.I. (2022) Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nature Genetics. 54(12):1839-1852
Wattrus, S.J., Smith, M.L., Rodrigues, C.P., Hagedorn, E.J., Kim, J.W., Budnik, B., Zon, L.I. (2022) Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science (New York, N.Y.). 377:1413-1419
Rubin, S.A., Baron, C.S., Pessoa Rodrigues, C., Duran, M., Corbin, A.F., Yang, S.P., Trapnell, C., Zon, L.I. (2022) Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish. The Journal of experimental medicine. 219(9)
Wcisel, D.J., Dornburg, A., McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O., Litman, G.W., Yoder, J.A. (2022) A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors. Immunogenetics. 75(1):53-69
Xu, H., Tong, G., Yan, T., Dong, L., Yang, X., Dou, D., Sun, Z., Liu, T., Zheng, X., Yang, J., Sun, X., Zhou, Y., Kuang, Y. (2022) Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish. Frontiers in cell and developmental biology. 10:821471
DiNapoli, S.E., Martinez-McFaline, R., Shen, H., Doane, A.S., Perez, A.R., Verma, A., Simon, A., Nelson, I., Balgobin, C.A., Bourque, C.T., Yao, J., Raman, R., Béguelin, W., Zippin, J.H., Elemento, O., Melnick, A.M., Houvras, Y. (2022) Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms. Frontiers in cell and developmental biology. 10:814216
Avagyan, S., Henninger, J.E., Mannherz, W.P., Mistry, M., Yoon, J., Yang, S., Weber, M.C., Moore, J.L., Zon, L.I. (2021) Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science (New York, N.Y.). 374:768-772
Zhang, F., Zeng, Q.Y., Xu, H., Xu, A.N., Liu, D.J., Li, N.Z., Chen, Y., Jin, Y., Xu, C.H., Feng, C.Z., Zhang, Y.L., Liu, D., Liu, N., Xie, Y.Y., Yu, S.H., Yuan, H., Xue, K., Shi, J.Y., Liu, T.X., Xu, P.F., Zhao, W.L., Zhou, Y., Wang, L., Huang, Q.H., Chen, Z., Chen, S.J., Zhou, X.L., Sun, X.J. (2021) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Cell discovery. 7:98
Wu, S., Chen, K., Xu, T., Ma, K., Gao, L., Fu, C., Zhang, W., Jing, C., Ren, C., Deng, M., Chen, Y., Zhou, Y., Pan, W., Jia, X. (2021) Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Frontiers in cell and developmental biology. 9:709923
García-Castillo, J., Alcaraz-Pérez, F., Martínez-Balsalobre, E., García-Moreno, D., Rossmann, M.P., Fernández-Lajarín, M., Bernabé-García, M., Pérez-Oliva, A.B., Rodríguez-Cortez, V.C., Bueno, C., Adatto, I., Agarwal, S., Menéndez, P., Zon, L.I., Mulero, V., Cayuela, M.L. (2021) Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 118(32):
He, S., Zimmerman, M.W., Layden, H.M., Berezovskaya, A., Etchin, J., Martel, M.W., Thurston, G., Jing, C.B., van Rooijen, E., Kaufman, C.K., Rodig, S.J., Zon, L.I., Patton, E.E., Mansour, M.R., Look, A.T. (2021) Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 40(38):5718-5729
Avagyan, S., Weber, M.C., Ma, S., Prasad, M., Mannherz, W.P., Yang, S., Buenrostro, J.D., Zon, L.I. (2021) Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages. Blood advances. 5:2673-2686
Yang, R.M., Zhan, M., Zhou, Q.Y., Ye, X.P., Wu, F.Y., Dong, M., Sun, F., Fang, Y., Zhang, R.J., Zhang, C.R., Yang, L., Guo, M.M., Zhang, J.X., Liang, J., Cheng, F., Liu, W., Han, B., Zhou, Y., Zhao, S.X., Song, H.D. (2021) Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis. Genetics in medicine : official journal of the American College of Medical Genetics. 23(10):1944-1951
Rossmann, M.P., Hoi, K., Chan, V., Abraham, B.J., Yang, S., Mullahoo, J., Papanastasiou, M., Wang, Y., Elia, I., Perlin, J.R., Hagedorn, E.J., Hetzel, S., Weigert, R., Vyas, S., Nag, P.P., Sullivan, L.B., Warren, C.R., Dorjsuren, B., Greig, E.C., Adatto, I., Cowan, C.A., Schreiber, S.L., Young, R.A., Meissner, A., Haigis, M.C., Hekimi, S., Carr, S.A., Zon, L.I. (2021) Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372:716-721
Khajavi, M., Zhou, Y., Schiffer, A.J., Bazinet, L., Birsner, A.E., Zon, L., D'Amato, R.J. (2021) Identification of Basp1 as a novel angiogenesis-regulating gene by multi-model system studies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21404
Ablain, J., Liu, S., Moriceau, G., Lo, R.S., Zon, L.I. (2021) SPRED1 deletion confers resistance to MAPK inhibition in melanoma. The Journal of experimental medicine. 218(3):
Patton, E.E., Mueller, K.L., Adams, D.J., Anandasabapathy, N., Aplin, A.E., Bertolotto, C., Bosenberg, M., Ceol, C.J., Chi, P., Herlyn, M., Holmen, S.L., Karreth, F.A., Kaufman, C.K., Khan, S., Kobold, S., Leucci, E., Levy, C., Lombard, D.B., Lund, A.W., Marie, K.L., Marine, J.C., Marais, R., McMahon, M., Robles-Espinoza, C.D., Ronai, Z.A., Samuels, Y., Soengas, M.S., Villanueva, J., Weeraratna, A.T., White, R.M., Yeh, I., Zhu, J., Zon, L.I., Hurlbert, M.S., Merlino, G. (2021) Melanoma models for the next generation of therapies. Cancer Cell. 39(5):610-631
Fazio, M., van Rooijen, E., Dang, M., van de Hoek, G., Ablain, J., Mito, J.K., Yang, S., Thomas, A., Michael, J., Fabo, T., Modhurima, R., Pessina, P., Kaufman, C.K., Zhou, Y., White, R.M., Zon, L.I. (2021) SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. eLIFE. 10:
Wattrus, S.J., Zon, L.I. (2021) Blood in the water: recent uses of zebrafish to study myeloid biology. Current opinion in hematology. 28:43-49
Minnoye, L., Taskiran, I.I., Mauduit, D., Fazio, M., Van Aerschot, L., Hulselmans, G., Christiaens, V., Makhzami, S., Seltenhammer, M., Karras, P., Primot, A., Cadieu, E., van Rooijen, E., Marine, J.C., Egidy, G., Ghanem, G.E., Zon, L., Wouters, J., Aerts, S. (2020) Cross-species analysis of enhancer logic using deep learning. Genome research. 30:1815-1834
Taylor, A.M., Macari, E.R., Chan, I.T., Blair, M.C., Doulatov, S., Vo, L.T., Raiser, D.M., Siva, K., Basak, A., Pirouz, M., Shah, A.N., McGrath, K., Humphries, J.M., Stillman, E., Alter, B.P., Calo, E., Gregory, R.I., Sankaran, V.G., Flygare, J., Ebert, B.L., Zhou, Y., Daley, G.Q., Zon, L.I. (2020) Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Science Translational Medicine. 12(566):
Fazio, M., van Rooijen, E., Mito, J.K., Modhurima, R., Weiskopf, E., Yang, S., Zon, L.I. (2020) Recurrent co-alteration of HDGF and SETDB1 on chromosome 1q drives cutaneous melanoma progression and poor prognosis. Pigment cell & melanoma research. 34(3):641-647
Hsu, J., Huang, H.T., Lee, C.T., Choudhuri, A., Wilson, N.K., Abraham, B.J., Moignard, V., Kucinski, I., Yu, S., Hyde, R.K., Tober, J., Cai, X., Li, Y., Guo, Y., Yang, S., Superdock, M., Trompouki, E., Calero-Nieto, F.J., Ghamari, A., Jiang, J., Gao, P., Gao, L., Nguyen, V., Robertson, A.L., Durand, E.M., Kathrein, K.L., Aifantis, I., Gerber, S.A., Tong, W., Tan, K., Cantor, A.B., Zhou, Y., Liu, P.P., Young, R.A., Göttgens, B., Speck, N.A., Zon, L.I. (2020) CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences of the United States of America. 117(38):23626-23635
Wattrus, S.J., Zon, L.I. (2020) A Transgenic System for Rapid Magnetic Enrichment of Rare Embryonic Cells. Zebrafish. 17(5):354-357
Johansson, J.A., Marie, K.L., Lu, Y., Brombin, A., Santoriello, C., Zeng, Z., Zich, J., Gautier, P., von Kriegsheim, A., Brunsdon, H., Wheeler, A.P., Dreger, M., Houston, D.R., Dooley, C.M., Sims, A.H., Busch-Nentwich, E.M., Zon, L.I., Illingworth, R.S., Patton, E.E. (2020) PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Developmental Cell. 54(3):317-332.e9
Makarova, N., Kalaparthi, V., Wang, A., Williams, C., Dokukin, M.E., Kaufman, C.K., Zon, L., Sokolov, I. (2020) Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish. Journal of the Mechanical Behavior of Biomedical Materials. 107:103746
Harris, J.M., Wang, A.Y., Boulanger-Weill, J., Santoriello, C., Foianini, S., Lichtman, J.W., Zon, L.I., Arlotta, P. (2020) Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects. Developmental Cell. 53:577-588.e7
Choi, J., Zhang, T., Vu, A., Ablain, J., Makowski, M.M., Colli, L.M., Xu, M., Hennessey, R.C., Yin, J., Rothschild, H., Gräwe, C., Kovacs, M.A., Funderburk, K.M., Brossard, M., Taylor, J., Pasaniuc, B., Chari, R., Chanock, S.J., Hoggart, C.J., Demenais, F., Barrett, J.H., Law, M.H., Iles, M.M., Yu, K., Vermeulen, M., Zon, L.I., Brown, K.M. (2020) Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nature communications. 11:2718
Fazio, M., Ablain, J., Chuan, Y., Langenau, D.M., Zon, L.I. (2020) Zebrafish patient avatars in cancer biology and precision cancer therapy. Nature reviews. Cancer. 20(5):263-273
Santoriello, C., Sporrij, A., Yang, S., Flynn, R.A., Henriques, T., Dorjsuren, B., Custo Greig, E., McCall, W., Stanhope, M.E., Fazio, M., Superdock, M., Lichtig, A., Adatto, I., Abraham, B.J., Kalocsay, M., Jurynec, M., Zhou, Y., Adelman, K., Calo, E., Zon, L.I. (2020) RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nature cell biology. 22(4):372-379
DiNapoli, S.E., Martinez-McFaline, R., Gribbin, C.K., Wrighton, P.J., Balgobin, C.A., Nelson, I., Leonard, A., Maskin, C.R., Shwartz, A., Quenzer, E.D., Mailhiot, D., Kao, C., McConnell, S.C., de Jong, J.L.O., Goessling, W., Houvras, Y. (2020) Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic acids research. 48(7):e38
Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):
Cassar, S., Adatto, I., Freeman, J.L., Gamse, J.T., Iturria, I., Lawrence, C., Muriana, A., Peterson, R., Van Cruchten, S., Zon, L. (2019) Use of Zebrafish in Drug Discovery Toxicology. Chemical Research in Toxicology. 33(1):95-118
Gómez-Abenza, E., Ibáñez-Molero, S., García-Moreno, D., Fuentes, I., Zon, L.I., Mione, M.C., Cayuela, M.L., Gabellini, C., Mulero, V. (2019) Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment. Journal of experimental & clinical cancer research : CR. 38:405
Li, P., Lahvic, J.L., Binder, V., Pugach, E.K., Riley, E.B., Tamplin, O.J., Panigrahy, D., Bowman, T.V., Barrett, F.G., Heffner, G.C., McKinney-Freeman, S., Schlaeger, T.M., Daley, G.Q., Zeldin, D.C., Zon, L.I. (2019) Author Correction: Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 573:E1
Tyrkalska, S.D., Pérez-Oliva, A.B., Rodríguez-Ruiz, L., Martínez-Morcillo, F.J., Alcaraz-Pérez, F., Martínez-Navarro, F.J., Lachaud, C., Ahmed, N., Schroeder, T., Pardo-Sánchez, I., Candel, S., López-Muñoz, A., Choudhuri, A., Rossmann, M.P., Zon, L.I., Cayuela, M.L., García-Moreno, D., Mulero, V. (2019) Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1. Immunity. 51(1):50-63.e5
Cagan, R.L., Zon, L.I., White, R.M. (2019) Modeling Cancer with Flies and Fish. Developmental Cell. 49:317-324
Gu, Q., Yang, X., Lv, J., Zhang, J., Xia, B., Kim, J.D., Wang, R., Xiong, F., Meng, S., Clements, T.P., Tandon, B., Wagner, D.S., Diaz, M.F., Wenzel, P.L., Miller, Y.I., Traver, D., Cooke, J.P., Li, W., Zon, L.I., Chen, K., Bai, Y., Fang, L. (2019) AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science (New York, N.Y.). 363:1085-1088
de Jong, J.L.O. (2019) Splicing up hematopoietic development. Blood. 133:770-771
Chaturantabut, S., Shwartz, A., Evason, K.J., Cox, A.G., Labella, K., Schepers, A.G., Yang, S., Aravena, M., Houvras, Y., Mancio-Silva, L., Romano, S., Gorelick, D.A., Cohen, D.E., Zon, L.I., Bhatia, S.N., North, T.E., Goessling, W. (2019) Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 156(6):1788-1804.e13
Baeten, J.T., Waarts, M.R., Pruitt, M.M., Chan, W.C., Andrade, J., de Jong, J.L.O. (2019) The side population enriches for leukemia propagating cell activity and Wnt pathway expression in zebrafish acute lymphoblastic leukemia. Haematologica. 104(7):1388-1395
Rost, M.S., Shestopalov, I., Liu, Y., Vo, A.H., Richter, C.E., Emly, S.M., Barrett, F.G., Stachura, D.L., Holinstat, M., Zon, L.I., Shavit, J.A. (2018) Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood advances. 2:3418-3427
Wattrus, S.J., Zon, L.I. (2018) Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish. Blood advances. 2:3063-3069
Ablain, J., Xu, M., Rothschild, H., Jordan, R.C., Mito, J.K., Daniels, B.H., Bell, C.F., Joseph, N.M., Wu, H., Bastian, B.C., Zon, L.I., Yeh, I. (2018) Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.. Science (New York, N.Y.). 362(6418):1055-1060
Yien, Y.Y., Shi, J., Chen, C., Cheung, J.T., Grillo, A.S., Shrestha, R., Li, L., Zhang, X., Kafina, M.D., Kingsley, P.D., King, M.J., Ablain, J., Li, H., Zon, L., Palis, J., Burke, M.D., Bauer, D.E., Orkin, S.H., Koehler, C.M., Phillips, J.D., Kaplan, J., Ward, D.M., Lodish, H.F., Paw, B.H. (2018) FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. The Journal of biological chemistry. 293(51):19797-19811
Parada-Kusz, M., Penaranda, C., Hagedorn, E.J., Clatworthy, A., Nair, A.V., Henninger, J.E., Ernst, C., Li, B., Riquelme, R., Jijon, H., Villablanca, E.J., Zon, L.I., Hung, D., Allende, M.L. (2018) Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Disease models & mechanisms. 11(11):
Baeten, J.T., de Jong, J.L.O. (2018) Genetic Models of Leukemia in Zebrafish. Frontiers in cell and developmental biology. 6:115
Mandelbaum, J., Shestopalov, I.A., Henderson, R.E., Chau, N.G., Knoechel, B., Wick, M.J., Zon, L.I. (2018) Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.. The Journal of experimental medicine. 215(10):2673-2685
Lahvic, J.L., Ammerman, M., Li, P., Blair, M.C., Stillman, E.R., Fast, E.M., Robertson, A.L., Christodoulou, C., Perlin, J.R., Yang, S., Chiang, N., Norris, P.C., Daily, M.L., Redfield, S.E., Chan, I.T., Chatrizeh, M., Chase, M.E., Weis, O., Zhou, Y., Serhan, C.N., Zon, L.I. (2018) Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proceedings of the National Academy of Sciences of the United States of America. 115(37):9252-9257
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Bussmann, J., Lawson, N., Zon, L., Schulte-Merker, S., and Zebrafish Nomenclature Committee. (2008) Zebrafish VEGF receptors: a guideline to nomenclature. PLoS Genetics. 4(5):e1000064
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Shmukler, B.E., Clark, J.S., Hsu, A., Vandorpe, D.H., Stewart, A.K., Kurschat, C.E., Choe, S.K., Zhou, Y., Amigo, J., Paw, B.H., and Alper, S.L. (2008) Zebrafish Ae2.2 encodes a second Slc4a2 anion exchanger. American journal of physiology. Regulatory, integrative and comparative physiology. 294(3):R1081-R1091
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Chen, M.C., Zhou, Y., and Detrich, H.W. III (2002) Zebrafish mitotic kinesin-like protein 1 (Mklp1) functions in embryonic cytokinesis. Physiological Genomics. 8(1):51-66
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