ZFIN ID: ZDB-LAB-970502-33
Burnside Lab
PI/Director: Burnside, Beth
Contact Person: Burnside, Beth
Email: burnside@berkeley.edu
URL: http://mcb.berkeley.edu/labs/burnside
Address: Department of Molecular and Cell Biology University of California, Berkeley 335 Life Sciences Addition #3200 Berkeley, CA 94720 USA
Country: United States
Phone: (510) 642-2439
Fax: (510) 643-6791
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
In the Burnside Lab we are using zebrafish to study Myosin III, which is a unconventional myosin highly expressed in retina and in the same class of myosins as Drosophila NINAC. We have mapped the genomic location of the human Myosin III gene, MYO3A, but it doesn't link to any known human retinal diseases. We have found two Myosin III genes in zebrafish and are currently mapping them to see if they are linked to any eye or retinal phenotypes in zebrafish.

We are also using zebrafish to look at the developmental and spatial expression of the Myosin III proteins. We are looking at both eye and other organs for expression of Myosin IIIs.


LAB MEMBERS
Dose, Andrea Post-Doc Lin-Jones, Jennifer Post-Doc Parker, Ed Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Giarmarco, M.M., Brock, D.C., Robbings, B.M., Cleghorn, W.M., Tsantilas, K.A., Kuch, K.C., Ge, W., Rutter, K.M., Parker, E.D., Hurley, J.B., Brockerhoff, S.E. (2020) Daily mitochondrial dynamics in cone photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. 117:28816-28827
Chou, S.W., Hwang, P., Gomez, G., Fernando, C.A., West, M.C., Pollock, L.M., Lin-Jones, J., Burnside, B., and McDermott, B.M. (2011) Fascin 2b Is a Component of Stereocilia that Lengthens Actin-Based Protrusions. PLoS One. 6(4):e14807
Lin-Jones, J., Sohlberg, L., Dosé, A., Breckler, J., Hillman, D.W., and Burnside, B. (2009) Identification and Localization of Myosin Superfamily Members in Fish Retina and Retinal Pigmented Epithelium. The Journal of comparative neurology. 513(2):209-223
Lin-Jones, J., and Burnside, B. (2007) Retina-specific protein fascin 2 is an actin cross-linker associated with actin bundles in photoreceptor inner segments and calycal processes. Investigative ophthalmology & visual science. 48(3):1380-1388
Seiler, C., Ben-David, O., Sidi, S., Hendrich, O., Rusch, A., Burnside, B., Avraham, K.B., and Nicolson, T. (2004) Myosin VI is required for structural integrity of the apical surface of sensory hair cells in zebrafish. Developmental Biology. 272(2):328-338
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