ZFIN Lab: Elks Lab

ZFIN ID: ZDB-LAB-231212-1

Elks Lab

PI/Director:	Elks, Philip
Contact Person:	Elks, Philip
Email:	p.elks@sheffield.ac.uk
URL:	https://elkslab.weebly.com/
Address:	Firth Court
Country:	United Kingdom
Phone:	01142223609
Fax:
Line Designation:	sh

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Using in vivo imaging to understand the innate immune response to infection.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Hammond, F.R., Lewis, A., Speirs, Z.C., Anderson, H.E., Sipka, T., Williams, L.G., Nguyen-Chi, M., Meijer, A.H., Wiegertjes, G.F., Elks, P.M. (2023) An arginase 2 promoter transgenic illuminates immune cell polarisation in zebrafish. Disease models & mechanisms. 16(6):

Isles, H.M., Loynes, C.A., Alasmari, S., Kon, F.C., Henry, K.M., Kadochnikova, A., Hales, J., Muir, C.F., Keightley, M.C., Kadirkamanathan, V., Hamilton, N., Lieschke, G.J., Renshaw, S.A., Elks, P.M. (2021) Pioneer neutrophils release chromatin within in vivo swarms. eLIFE. 10:

Schild, Y., Mohamed, A., Wootton, E.J., Lewis, A., Elks, P.M. (2020) Hif-1alpha stabilisation is protective against infection in zebrafish comorbid models. The FEBS journal. 287(18):3925-3943

Plant, T., Eamsamarng, S., Sanchez-Garcia, M.A., Reyes, L., Renshaw, S.A., Coelho, P., Mirchandani, A.S., Morgan, J.M., Ellett, F.E., Morrison, T., Humphries, D., Watts, E.R., Murphy, F., Raffo-Iraolagoitia, X.L., Zhang, A., Cash, J.L., Loynes, C., Elks, P.M., Van Eeden, F., Carlin, L.M., Furley, A.J.W., Whyte, M.K.B., Walmsley, S.R. (2020) Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. The Journal of Clinical Investigation. 130(6):3221-3237

Stirling, D.R., Suleyman, O., Gil, E., Elks, P.M., Torraca, V., Noursadeghi, M., Tomlinson, G.S. (2020) Analysis tools to quantify dissemination of pathology in zebrafish larvae. Scientific Reports. 10:3149

Lewis, A., Elks, P.M. (2019) Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo. Frontiers in immunology. 10:2321

Isles, H.M., Herman, K.D., Robertson, A.L., Loynes, C.A., Prince, L.R., Elks, P.M., Renshaw, S.A. (2019) The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish. Frontiers in immunology. 10:1784

Hodgkinson, J.W., Belosevic, M., Elks, P.M., Barreda, D.R. (2019) Teleost contributions to the understanding of mycobacterial diseases. Developmental and comparative immunology. 96:111-125

Ogryzko, N.V., Lewis, A., Wilson, H.L., Meijer, A.H., Renshaw, S.A., Elks, P.M. (2018) Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 202(2):494-502

Wiegertjes, G.F., Wentzel, A.S., Spaink, H.P., Elks, P.M., Fink, I.R. (2016) Polarization of immune responses in fish: The 'macrophages first' point of view. Molecular immunology. 69:146-56

Felber, K., Elks, P.M., Lecca, M., Roehl, H.H. (2015) Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation. PLoS One. 10:e0144982

Ellett, F., Elks, P.M., Robertson, A.L., Ogryzko, N.V., Renshaw, S.A. (2015) Defining the phenotype of neutrophils following reverse migration in zebrafish. Journal of Leukocyte Biology. 98(6):975-81

Elks, P.M., van der Vaart, M., van Hensbergen, V., Schutz, E., Redd, M.J., Murayama, E., Spaink, H.P., Meijer, A.H. (2014) Mycobacteria Counteract a TLR-Mediated Nitrosative Defense Mechanism in a Zebrafish Infection Model. PLoS One. 9:e100928

Thompson, A.A., Elks, P.M., Marriott, H.M., Eamsamarng, S., Higgins, K.R., Lewis, A., Williams, L., Parmar, S., Shaw, G., McGrath, E.E., Formenti, F., Van Eeden, F.J., Kinnula, V.L., Pugh, C.W., Sabroe, I., Dockrell, D.H., Chilvers, E.R., Robbins, P.A., Percy, M.J., Simon, M.C., Johnson, R.S., Renshaw, S.A., Whyte, M.K., and Walmsley, S.R. (2014) Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 123(3):366-76

Harris, J.M., Esain, V., Frechette, G.M., Harris, L.J., Cox, A.G., Cortes, M., Garnaas, M.K., Carroll, K.J., Cutting, C.C., Khan, T., Elks, P.M., Renshaw, S.A., Dickinson, B.C., Chang, C.J., Murphy, M.P., Paw, B.H., Vander Heiden, M.G., Goessling, W., and North, T.E. (2013) Glucose metabolism impacts the spatio-temporal onset and magnitude of HSC induction in vivo. Blood. 121(13):2483-2493

Elks, P.M., Brizee, S., van der Vaart, M., Walmsley, S.R., van Eeden, F.J., Renshaw, S.A., and Meijer, A.H. (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS pathogens. 9(12):e1003789

Santhakumar, K., Judson, E.C., Elks, P.M., McKee, S., Elworthy, S., van Rooijen, E., Walmsley, S.S., Renshaw, S., Cross, S.S., and van Eeden, F.J. (2012) A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis. Cancer research. 72(16):4017-4027

Dixon, G., Elks, P.M., Loynes, C.A., Whyte, M.K., and Renshaw, S.A. (2012) A Method for the In Vivo Measurement of Zebrafish Tissue Neutrophil Lifespan. ISRN Hematology. 2012:915868

Holmes, G.R., Dixon, G., Anderson, S.R., Reyes-Aldasoro, C.C., Elks, P.M., Billings, S.A., Whyte, M.K., Kadirkamanathan, V., and Renshaw, S.A. (2012) Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model. Advances in hematology. 2012:792163

Kadirkamanathan, V., Anderson, S.R., Billings, S.A., Zhang, X., Holmes, G.R., Reyes-Aldasoro, C.C., Elks, P.M., and Renshaw, S.A. (2012) The Neutrophil's Eye-View: Inference and Visualisation of the Chemoattractant Field Driving Cell Chemotaxis In Vivo. PLoS One. 7(4):e35182

Elks, P.M., van Eeden, F.J., Dixon, G., Wang, X., Reyes-Aldasoro, C.C., Ingham, P.W., Whyte, M.K., Walmsley, S.R., and Renshaw, S.A. (2011) Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model. Blood. 118(3):712-22

Elks, P.M., Loynes, C.A., and Renshaw, S.A. (2011) Measuring Inflammatory Cell Migration in the Zebrafish. Methods in molecular biology (Clifton, N.J.). 769:261-275

Li, N., Felber, K., Elks, P., Croucher, P., and Roehl, H.H. (2009) Tracking gene expression during zebrafish osteoblast differentiation. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(2):459-466