Micro- and nano-technologies together with sensing and wireless innovations have been emerging recently as essential assets to enhance healthcare and life-science investigations. Cost and care efficiency, quality and efficacy in hospitals, as well as pharmacology and science discoveries have obtained great benefits from multidisciplinary researches. While micro- and nano-fabrication provided miniaturized sensors and systems with better sensitivity, selectivity and longevity at minimal power consumption; wireless technology and innovations in electronics helped in cutting healthcare cost, bringing convenience to patients and establishing distanced care which was recently defined as personalized- and tele-medicine of the mobile-health (m-Health) network. Towards this end, the objectives of HERO laboratory are to introduce a paradigm shift of applying innovative engineering tools for biological investigations and to bridge expertise in different fields providing novel healthcare devices.