ZFIN Lab: Pradhan Lab

ZFIN ID: ZDB-LAB-210304-3

Pradhan Lab

PI/Director:	Pradhan, Ajay
Contact Person:
Email:	ajay.pradhan@oru.se
URL:
Address:
Country:
Phone:	019 303735
Fax:
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Pradhan’s lab is interested in understanding the thyroid hormone‘s role in gonadal and brain sex differentiation using zebrafish as a model system.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Dai, X., Pradhan, A., Liu, J., Liu, R., Zhai, G., Zhou, L., Dai, J., Shao, F., Yuan, Z., Wang, Z., Yin, Z. (2023) Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions. Biology of sex differences. 14:5353

Saad, N., Bereketoglu, C., Pradhan, A. (2021) Di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) alters transcriptional profiles, lipid metabolism and behavior in zebrafish larvae. Heliyon. 7:e07951

Bereketoglu, C., Pradhan, A., Olsson, P.E. (2020) Nonsteroidal anti-inflammatory drugs (NSAIDs) cause male-biased sex differentiation in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 223:105476

Shu, T., Zhai, G., Pradhan, A., Olsson, P.E., Yin, Z. (2020) Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation. General and comparative endocrinology. 295:113490

Pradhan, A., Bereketoglu, C., Martin, L., Duhagon, J., Olsson, P.E. (2019) The food preservative ethoxyquin impairs zebrafish development, behavior and alters gene expression profile. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 135:110926

Bereketoglu, C., Pradhan, A. (2019) Comparative transcriptional analysis of methylparaben and propylparaben in zebrafish. The Science of the total environment. 671:129-139

Saju, J.M., Hossain, M.S., Liew, W.C., Pradhan, A., Thevasagayam, N.M., Tan, L.S.E., Anand, A., Olsson, P.E., Orbán, L. (2018) Heat Shock Factor 5 Is Essential for Spermatogenesis in Zebrafish. Cell Reports. 25:3252-3261.e4

Pradhan, A., Olsson, P.E. (2018) Germ cell depletion in zebrafish leads to incomplete masculinization of the brain. General and comparative endocrinology. 265:15-21

Pradhan, A., Ivarsson, P., Ragnvaldsson, D., Berg, H., Jass, J., Olsson, P.E. (2017) Transcriptional responses of zebrafish to complex metal mixtures in laboratory studies overestimates the responses observed with environmental water. The Science of the total environment. 584-585:1138-1146

Pradhan, A., Olsson, P. (2016) Regulation of Zebrafish Gonadal Sex Differentiation. AIMS Molecular Science. 3:567-584

Pradhan, A., Olsson, P.E. (2015) Zebrafish sexual behavior: role of sex steroid hormones and prostaglandins. Behavioral and brain functions : BBF. 11:23

Pradhan, A., Olsson, P.E. (2015) Inhibition of retinoic acid synthesis disrupts spermatogenesis and fecundity in zebrafish. General and comparative endocrinology. 217-218:81-91

Pradhan, A., Asnake, S., Kharlyngdoh, J.B., Modig, C., Olsson, P.E. (2015) In silico and biological analysis of anti-androgen activity of the brominated flame retardants ATE, BATE and DPTE in zebrafish. Chemico-biological interactions. 233:35-45

Pradhan, A., Olsson, P.E. (2014) Juvenile Ovary to Testis Transition in Zebrafish Involves Inhibition of Ptges. Biology of reproduction. 91(2):33

Pradhan, A., Kharlyngdoh, J.B., Asnake, S., and Olsson, P.E. (2013) The brominated flame retardant TBECH activates the zebrafish (Danio rerio) androgen receptor, alters gene transcription and causes developmental disturbances. Aquatic toxicology (Amsterdam, Netherlands). 142-143C:63-72

Pradhan, A., Khalaf, H., Ochsner, S.A., Sreenivasan, R., Koskinen, J., Karlsson, M., Karlsson, J., McKenna, N.J., Orban, L., and Olsson, P.E. (2012) Activation of NF-kappaB prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish. The Journal of biological chemistry. 287(45):37926-37938