ZFIN ID: ZDB-LAB-200917-1
Dahai Yang Lab
PI/Director: Yang, Dahai
Contact Person: Yang, Dahai
Email: dahaiyang@ecust.edu.cn
URL: http://biotech.ecust.edu.cn/2019/0423/c7935a88262/page.htm
Address: East China University of Science and Technology 130 Meilong Rd. Shanghai, 200237
Country: China
Phone: 86-21-64253065
Fax:
Line Designation: eib


GENOMIC FEATURES ORIGINATING FROM THIS LAB
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STATEMENT OF RESEARCH INTERESTS
Dr. Dahai Yang’s group is interested in fundamental research in microbial-host interactions, innate immune responses, the pathogenesis of inflammatory disease. Specifically, the research focuses on mechanistic studies to understand the role of bacterial infection-induced pyroptosis in regulating multi-organ dysfunction during sepsis. Several approaches that include biochemical reconstitution, cell biology, analysis of genetically modified mutant mice, and zebrafish genetics to identify new components in pathogen-induced inflammasome activation and to further reveal the underlying biochemical mechanism involved in the interaction between microbial/endogenous molecules and sepsis.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Wang, Z., You, X., Zhang, Y., Liu, Q., Yang, D. (2023) Poly(I:C) induces anti-inflammatory response against secondary LPS challenge in zebrafish larvae. Fish & shellfish immunology. 144:109285
Wang, Y., Jin, Y., Sun, F., Zhang, Y., Liu, Q., Wang, Q., Yang, D., Zhang, Y. (2023) The c-di-GMP signalling component YfiR regulates multiple bacterial phenotypes and virulence in Pseudomonas plecoglossicida. Journal of applied microbiology. 134(7):
Chen, H., Wu, X., Gu, Z., Chen, S., Zhou, X., Zhang, Y., Liu, Q., Wang, Z., Yang, D. (2021) Zebrafish gasdermin E cleavage-engaged pyroptosis by inflammatory and apoptotic caspases. Developmental and comparative immunology. 124:104203
Wang, Z., Gu, Z., Hou, Q., Chen, W., Mu, D., Zhang, Y., Liu, Q., Liu, Z., Yang, D. (2020) Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic-Acute Kidney Injury In Vivo. Journal of immunology (Baltimore, Md. : 1950). 204(7):1929-1942