ZFIN Lab: Rosowski Lab

ZFIN ID: ZDB-LAB-200302-1

ZFIN ID: ZDB-LAB-200302-1

Rosowski Lab

PI/Director:	Rosowski, Emily E.
Contact Person:	Rosowski, Emily E.
Email:	erosows@clemson.edu
URL:	http://rosowski-lab.net
Address:	190 Collings St Life Sciences Facility 160C Clemson University Clemson, SC 29634
Country:	United States
Phone:	8646565433
Fax:
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

We are broadly interested in host-pathogen interactions, using the larval zebrafish as a model host. Our current focus is on understanding how the innate immune system combats infection with the fungus Aspergillus fumigatus.

LAB MEMBERS

Thrikawala, Savini Post-Doc

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Tanner, C.D., Rosowski, E.E. (2024) Macrophages inhibit extracellular hyphal growth of A. fumigatus through Rac2 GTPase signaling. Infection and Immunity. 92(2):e0038023

Rosowski, E.E. (2023) mSphere of Influence: How host genetics impact microbial pathogenesis and treatment of infectious disease. mSphere. 9(1):e0062923

Thrikawala, S., Mesmar, F., Bhattacharya, B., Muhsen, M., Mukhopadhyay, S., Flores, S., Upadhyay, S., Vergara, L., Gustafsson, J.Å., Williams, C., Bondesson, M. (2023) Triazole fungicides induce adipogenesis and repress osteoblastogenesis in zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 193(2):119-130

Thrikawala, S., Niu, M., Keller, N.P., Rosowski, E.E. (2022) Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish. PLoS pathogens. 18:e1010040

Houseright, R.A., Rosowski, E.E., Lam, P.Y., Tauzin, S.J.M., Mulvaney, O., Dewey, C.N., Huttenlocher, A. (2020) Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Scientific Reports. 10:15716

Thrikawala, S., Rosowski, E.E. (2020) Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions. Journal of visualized experiments : JoVE. (159):

Rosowski, E.E. (2020) Determining macrophage versus neutrophil contributions to innate immunity using larval zebrafish. Disease models & mechanisms. 13(1):

Rosowski, E.E., He, J., Huisken, J., Keller, N.P., Huttenlocher, A. (2019) Efficacy of voriconazole against A. fumigatus infection depends on host immune function. Antimicrobial Agents and Chemotherapy. 64(2):

Schoen, T.J., Rosowski, E.E., Knox, B.P., Bennin, D., Keller, N.P., Huttenlocher, A. (2019) Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish. Journal of Cell Science. 133(5):

Pinto, C., Hao, R., Grimaldi, M., Thrikawala, S., Boulahtouf, A., Aït-Aïssa, S., Brion, F., Gustafsson, J.Å., Balaguer, P., Bondesson, M. (2019) Differential activity of BPA, BPAF and BPC on zebrafish estrogen receptors in vitro and in vivo. Toxicology and applied pharmacology. 380:114709

Rosowski, E.E., Knox, B.P., Archambault, L.S., Huttenlocher, A., Keller, N.P., Wheeler, R.T., Davis, J.M. (2018) The Zebrafish as a Model Host for Invasive Fungal Infections. Journal of fungi (Basel, Switzerland). 4(4)

Rosowski, E.E., Raffa, N., Knox, B.P., Golenberg, N., Keller, N.P., Huttenlocher, A. (2018) Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing. PLoS pathogens. 14:e1007229

Rosowski, E.E., Deng, Q., Keller, N.P., Huttenlocher, A. (2016) Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 197(12):4780-4790

Rosowski, E.E., Huttenlocher, A. (2015) Neutrophils, wounds, and cancer progression. Developmental Cell. 34:134-6