ZFIN ID: ZDB-LAB-191028-1
Nath Lab
PI/Director: Nath, Anjali
Contact Person: Nath, Anjali
Email: anath1@bidmc.harvard.edu
URL: http://scholar.harvard.edu/anjali-nath-lab
Address: Center for Life Sciences CLS-917 Beth Israel Deaconess Medical Center 3 Blackfan Circle, Boston, MA, 02215
Country: United States
Phone: 6174354209
Fax: 617 7354202
Line Designation: biz

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Our lab works at the interface of human genetics and drug discovery. We systematically identify connections between genes and the human biology they regulate through the integration of multiomic human datasets. The overarching goals of these analyses are to determine the function of understudied genes and to identify novel druggable targets. We then use the tools of chemical biology in combination with zebrafish genetic models to dissect the molecular mechanisms of these associations and to identify lead compounds. Our overarching goal is to develop small molecules that modulate the activity of cardiometabolic disease associated genes.

Jagtap, Urmila Post-Doc Budrow, Nadine Fish Facility Staff Cabral, Cindy Administrative Staff
Chen, Zsu-Zsu Morningstar, Jordan

Chaturantabut, S., Shwartz, A., Garnaas, M.K., LaBella, K., Li, C.C., Carroll, K.J., Cutting, C.C., Budrow, N., Palaria, A., Gorelick, D.A., Tremblay, K.D., North, T.E., Goessling, W. (2020) Estrogen acts via estrogen receptor 2b to regulate hepatobiliary fate during vertebrate development. Hepatology (Baltimore, Md.). 72(5):1786-1799
Nath, A.K., Ma, J., Chen, Z.Z., Li, Z., Vitery, M.D.C., Kelley, M.L., Peterson, R.T., Gerszten, R.E., Yeh, J.J. (2020) Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:1546-1557
Jagtap, U., Sivadas, A., Basu, S., Verma, A., Sivasubbu, S., Scaria, V., Sachidanandan, C. (2019) A Temporal Map of Gene Expression Pattern During Zebrafish Liver Regeneration. Zebrafish. 17(1):1-10
Morningstar, J., Lee, J., Hendry-Hofer, T., Witeof, A., Lyle, L.T., Knipp, G., MacRae, C.A., Boss, G.R., Peterson, R.T., Davisson, V.J., Gerszten, R.E., Bebarta, V.S., Mahon, S., Brenner, M., Nath, A.K. (2018) Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1:81-92
Sips, P.Y., Shi, X., Musso, G., Nath, A.K., Zhao, Y., Nielson, J., Morningstar, J., Kelly, A.E., Mikell, B., Buys, E., Bebarta, V., Rutter, J., Davisson, V.J., Mahon, S., Brenner, M., Boss, G.R., Peterson, R.T., Gerszten, R.E., MacRae, C.A. (2018) Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 13:e0193889
Nath, A.K., Shi, X., Harrison, D.L., Morningstar, J.E., Mahon, S., Chan, A., Sips, P., Lee, J., MacRae, C.A., Boss, G.R., Brenner, M., Gerszten, R.E., Peterson, R.T. (2017) Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell chemical biology. 24(5):565-575.e4
Kimberly, W.T., O’Sullivan, J., Nath, A.K., Keyes, M., Yang, Q., Larson, M.G., Ramachandran, V., Peterson, R.T., Wang, T.J., Corey, .K, Gerszten, R.E. (2017) Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis. JCI insight. 2(9)
Nath, A.K., Ryu, J.H., Jin, Y.N., Roberts, L.D., Dejam, A., Gerszten, R.E., Peterson, R.T. (2015) PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation. Cell Reports. 10(5):694-701
Nath, A.K., Roberts, L.D., Liu, Y., Mahon, S.B., Kim, S., Ryu, J.H., Werdich, A., Januzzi, J.L., Boss, G.R., Rockwood, G.A., MacRae, C.A., Brenner, M., Gerszten, R.E., and Peterson, R.T. (2013) Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(5):1928-1938