ZFIN Lab: Mokalled Lab

ZFIN ID: ZDB-LAB-170802-1

ZFIN ID: ZDB-LAB-170802-1

Mokalled Lab

PI/Director:	Mokalled, Mayssa
Contact Person:	Mokalled, Mayssa
Email:	mmokalled@wustl.edu
URL:	http://www.mokalledlab.com/
Address:	Washington University School of Medicine Department of Developmental Biology 4523 Clayton Ave, CB 8103 St. Louis, MO 63110
Country:	United States
Phone:	(314) 273-1835
Fax:
Line Designation:	stl

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 9 genomic features

STATEMENT OF RESEARCH INTERESTS

The Mokalled lab aims at exploring and promoting spinal cord (SC) repair after injury or disease.
Regenerative capacity is unevenly distributed across organisms. While mammals exhibit limited abilities to repair SC damage, adult zebrafish are capable of remarkable cellular and functional regeneration after complete SC transection.
Our current research projects are focused on:
1) Elucidating cellular and molecular mechanisms of glial bridging after SC transection in zebrafish.
2) Investigating mechanisms of neurogenesis and functional repair in zebrafish.
3) Performing comparative studies to uncover the bases for differential regenerative capacity between the highly regenerative zebrafish and poorly regenerative mouse models.
The central goal of our research is to inspire and guide innovative molecular and cellular approaches for SC treatment.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Burris, B., Mokalled, M.H. (2024) Spinal Cord Injury and Assays for Regeneration. Methods in molecular biology (Clifton, N.J.). 2707:215222215-222

Jensen, N.O., Burris, B., Zhou, L., Yamada, H., Reyes, C., Pincus, Z., Mokalled, M.H. (2023) Functional trajectories during innate spinal cord repair. Frontiers in molecular neuroscience. 16:11557541155754

Zhou, L., McAdow, A.R., Yamada, H., Burris, B., Klatt Shaw, D., Oonk, K., Poss, K.D., Mokalled, M.H. (2023) Progenitor-derived glia are required for spinal cord regeneration in zebrafish. Development (Cambridge, England). 150(10):

Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Dogra, D., Reischauer, S., Mokalled, M.H. (2022) Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish. Cell Reports. 41:111705111705

Klatt Shaw, D., Mokalled, M.H. (2021) Efficient CRISPR/Cas9 mutagenesis for neurobehavioral screening in adult zebrafish. G3 (Bethesda). 11(8):

Klatt Shaw, D., Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Butka, E., Morris, S.A., Dietmann, S., Mokalled, M.H. (2021) Localized EMT reprograms glial progenitors to promote spinal cord repair. Developmental Cell. 56(5):613-626.e7

Whittle, J., Antunes, L., Harris, M., Upshaw, Z., Sepich, D.S., Johnson, A.N., Mokalled, M., Solnica-Krezel, L., Dobbs, M.B., Gurnett, C.A. (2020) MYH3-associated distal arthrogryposis zebrafish model is normalized with para-aminoblebbistatin. EMBO Molecular Medicine. 12(11):e12356

Hou, Y., Lee, H.J., Chen, Y., Ge, J., Osman, F.O.I., McAdow, A.R., Mokalled, M.H., Johnson, S.L., Zhao, G., Wang, T. (2020) Cellular diversity of the regenerating caudal fin. Science advances. 6:eaba2084

Mokalled, M.H., Poss, K.D. (2018) A Regeneration Toolkit. Developmental Cell. 47:267-280

Mokalled, M.H., Patra, C., Dickson, A.L., Endo, T., Stainier, D.Y., Poss, K.D. (2016) Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. Science (New York, N.Y.). 354:630-634

Johnson, A.N., Mokalled, M.H., Valera, J.M., Poss, K.D., and Olson, E.N. (2013) Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. Development (Cambridge, England). 140(17):3645-3656