ZFIN Lab: Baoquan Zhao Lab

ZFIN ID: ZDB-LAB-170511-1

ZFIN ID: ZDB-LAB-170511-1

Baoquan Zhao Lab

PI/Director:	Zhao, Baoquan
Contact Person:	Zhao, Baoquan
Email:	baoquanzhao@126.com
URL:
Address:	Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, 27 Taiping Road, Building 2-227 Beijing 100850, P. R. of China.
Country:	China
Phone:	86-10-66874609
Fax:
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

We generated a new AD transgenic model by knocking a mutant human APP gene (APPsw) in zebrafish with appb promoter of zebrafish to drive the expression of APPsw. APPsw transgenic zebrafish well simulate the pathological characters of AD and can be used as an economic AD transgenic model.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Wang, H., Kang, G., Ma, C., Lian, H., Zhao, K., Zhao, B., Feng, Y., Dong, W. (2024) Inhibitory Effect of Acetaminophen on Ocular Pigmentation and its Relationship with Thyroxine in Zebrafish Embryos. Bulletin of environmental contamination and toxicology. 112:3939

Zhao, D., Liu, J., Zhou, Y., Zhang, L., Zhong, Y., Yang, Y., Zhao, B., Yang, M., Wang, Y. (2023) Penetrating the Blood-Brain Barrier for Targeted Treatment of Neurotoxicant Poisoning by Nanosustained-Released 2-PAM@VB1-MIL-101-NH₂(Fe). ACS applied materials & interfaces. 15(10):12631-12642

Li, Z., Huo, X., Chen, K., Yang, F., Tan, W., Zhang, Q., Yu, H., Li, C., Zhou, D., Chen, H., Zhao, B., Wang, Y., Chen, Z., Du, X. (2022) Profilin 2 and Endothelial Exosomal Profilin 2 Promote Angiogenesis and Myocardial Infarction Repair in Mice. Frontiers in cardiovascular medicine. 9:781753

Chen, C., Ni, X., Yin, X., Chen, H., Zhou, Y., Sun, H., Qi, C., Bu, N., Wang, S., Yu, J., Yang, J., Ao, W., Zhao, B., Dong, W. (2022) Developmental disorders caused by cefixime in the otic vesicles of zebrafish embryos or larvae. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 255:109295

Ding, G., Wang, T., Han, Z., Tian, L., Cheng, Q., Luo, L., Zhao, B., Wang, C., Feng, S., Wang, L., Meng, Z., Meng, Q. (2021) Substance P containing peptide gene delivery vectors for specifically transfecting glioma cells mediated by a neurokinin-1 receptor. Journal of materials chemistry. B. 9(32):6347-6356

Liang, M., Gao, C., Wang, Y., Gong, W., Fu, S., Cui, L., Zhou, Z., Chu, X., Zhang, Y., Liu, Q., Zhao, X., Zhao, B., Yang, M., Li, Z., Yang, C., Xie, X., Yang, Y., Gao, C. (2018) Enhanced blood-brain barrier penetration and glioma therapy mediated by T7 peptide-modified low-density lipoprotein particles. Drug delivery. 25:1652-1663

Li, X., Zha, X., Wang, Y., Jia, R., Hu, B., Zhao, B. (2018) Toxic effects and foundation of proton radiation on the early-life stage of zebrafish development. Chemosphere. 200:302-312

Meng, Z., Kang, Z., Sun, C., Yang, S., Zhao, B., Feng, S., Meng, Q., Liu, K. (2018) Enhanced gene transfection efficiency by use of peptide vectors containing laminin receptor-targeting sequence YIGSR. Nanoscale. 10(3):1215-1227

Chen, Z., Zhai, M., Xie, X., Zhang, Y., Ma, S., Li, Z., Yu, F., Zhao, B., Zhang, M., Yang, Y., Mei, X. (2017) Apoferritin Nanocage for Brain Targeted Doxorubicin Delivery. Molecular pharmaceutics. 14:3087-3097

Pu, Y.Z., Liang, L., Fu, A.L., Liu, Y., Sun, L., Li, Q., Wu, D., Sun, M.J., Zhang, Y.G., Zhao, B.Q. (2017) Generation of Alzheimer's Disease Transgenic Zebrafish Expressing Human APP Mutation under Control of Zebrafish appb Promotor. Current Alzheimer research. 14(6):668-679

Zhao, B., Sun, L., Zhang, W., Wang, Y., Zhu, Z., Zhu, X., Yang, L., Li, C., Zhang, Z., and Zhang, Y. (2014) Secretion of intestinal goblet cells: A novel excretion pathway of nanoparticles. Nanomedicine : nanotechnology, biology, and medicine. 10(4):839-49

Wang, K., Ma, J., He, M., Gao, G., Xu, H., Sang, J., Wang, Y., Zhao, B., and Cui, D. (2013) Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos. Theranostics. 3(4):258-266