ZFIN ID: ZDB-LAB-160509-1
Hahn Lab
PI/Director: Hahn, Mark E.
Contact Person: Hahn, Mark E.
Email: mhahn@whoi.edu
URL: http://www2.whoi.edu/site/hahnlab/
Address: Biology Department Woods Hole Oceanographic Institution MS-32 Woods Hole, MA 02543
Country: United States
Phone: 508-289-3242
Fax: 508-457-2134
Line Designation: wh


Molecular mechanisms of developmental toxicity; aryl hydrocarbon receptor signaling in development; regulation of gene expression in response to oxidative stress during development; Nrf2 (Nfe2l2) signaling; evolution of bHLH-PAS and CNC-bZIP transcription factor families.

Panlilio, Jennifer Martinez Graduate Student Franks, Diana Research Staff Karchner, Sibel Research Staff
Mickiewicz, Zachary Technical Staff

Brun, N.R., Panlilio, J.M., Zhang, K., Zhao, Y., Ivashkin, E., Stegeman, J.J., Goldstone, J.V. (2021) Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish. Communications biology. 4:1129
Panlilio, J.M., Jones, I.T., Salanga, M.C., Aluru, N., Hahn, M.E. (2021) Developmental exposure to domoic acid disrupts startle response behavior and circuitry in zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 182(2):310-326
Panlilio, J.M., Aluru, N., Hahn, M.E. (2020) Developmental Neurotoxicity of the Harmful Algal Bloom Toxin Domoic Acid: Cellular and Molecular Mechanisms Underlying Altered Behavior in the Zebrafish Model. Environmental health perspectives. 128:117002
Aluru, N., Karchner, S.I. (2020) PCB126 exposure revealed alterations in m6A RNA modifications in transcripts associated with AHR activation. Toxicological sciences : an official journal of the Society of Toxicology. 179(1):84-94
Shankar, P., Dasgupta, S., Hahn, M.E., Tanguay, R.L. (2020) A Review of the Functional Roles of the Zebrafish Aryl Hydrocarbon Receptors. Toxicological sciences : an official journal of the Society of Toxicology. 178(2):215-238
Hahn, M.E., Sadler, K.C. (2020) Casting a wide net: use of diverse model organisms to advance toxicology. Disease models & mechanisms. 13(4)
Aluru, N., Krick, K.S., McDonald, A.M., Karchner, S.I. (2019) Developmental exposure to PCB153 (2,2',4,4',5,5'-hexachlorobiphenyl) alters circadian rhythms and the expression of clock and metabolic genes. Toxicological sciences : an official journal of the Society of Toxicology. 173(1):41-52
Blanco-Sánchez, B., Clément, A., Fierro, J., Stednitz, S., Phillips, J.B., Wegner, J., Panlilio, J.M., Peirce, J.L., Washbourne, P., Westerfield, M. (2018) Grxcr1 Promotes Hair Bundle Development by Destabilizing the Physical Interaction between Harmonin and Sans Usher Syndrome Proteins. Cell Reports. 25:1281-1291.e4
Ulin, A., Henderson, J., Pham, M.T., Meyo, J., Chen, Y., Karchner, S.I., Goldstone, J.V., Hahn, M.E., Williams, L.M. (2018) Developmental Regulation of Nuclear Factor Erythroid-2 Related Factors (nrfs) by AHR1b in zebrafish (Danio rerio). Toxicological sciences : an official journal of the Society of Toxicology. 167(2):536-545
Aluru, N., Karchner, S.I., Krick, K.S., Zhu, W., Liu, J. (2018) Role of DNA methylation in altered gene expression patterns in adult zebrafish (Danio rerio) exposed to 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB 126).. Environmental Epigenetics. 4:dvy005
Holland, E.B., Goldstone, J.V., Pessah, I.N., Whitehead, A., Reid, N.M., Karchner, S.I., Hahn, M.E., Nacci, D.E., Clark, B.W., Stegeman, J.J. (2017) Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Aquatic toxicology (Amsterdam, Netherlands). 192:105-115
Sant, K.E., Hansen, J.M., Williams, L.M., Tran, N.L., Goldstone, J.V., Stegeman, J.J., Hahn, M.E., Timme-Laragy, A. (2017) The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biology. 13:207-218
Aluru, N., Karchner, S.I., Glazer, L. (2017) Early life exposure to low levels of AHR agonist PCB126 (3,3',4,4',5-pentachlorobiphenyl) reprograms gene expression in adult brain. Toxicological sciences : an official journal of the Society of Toxicology. 160(2):386-397
Wincent, E., Kubota, A., Timme-Laragy, A., Jönsson, M.E., Hahn, M.E., Stegeman, J.J. (2016) Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochemical pharmacology. 110-111:117-29
Glazer, L., Hahn, M.E., Aluru, N. (2016) Delayed effects of developmental exposure to low levels of the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB126) on adult zebrafish behavior. Neurotoxicology. 52:134-43
Hahn, M.E., Timme-Laragy, A.R., Karchner, S.I., Stegeman, J.J. (2015) Nrf2 and Nrf2-related proteins in development and developmental toxicity:Insights from studies in zebrafish (danio rerio). Free radical biology & medicine. 88(Pt B):275-89
Rousseau, M.E., Sant, K.E., Borden, L.R., Franks, D.G., Hahn, M.E., Timme-Laragy, A.R. (2015) Regulation of Ahr signaling by Nrf2 during development: Effects of Nrf2a deficiency on PCB126 embryotoxicity in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 167:157-171
Hahn, M.E., McArthur, A.G., Karchner, S.I., Franks, D.G., Jenny, M.J., Timme-Laragy, A.R., Stegeman, J.J., Woodin, B.R., Cipriano, M.J., Linney, E. (2014) The Transcriptional Response to Oxidative Stress during Vertebrate Development: Effects of tert-Butylhydroquinone and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. PLoS One. 9:e113158
Lowe, M. M., Mold, J. E., Kanwar, B., Huang, Y., Louie, A., Pollastri, M. P., Wang, C., Patel, G., Franks, D. G., Schlezinger, J., Sherr, D. H., Silverstone, A. E., Hahn, M. E., McCune, J. M. (2014) Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production. PLoS One. 9(2):e87877
Timme-Laragy, A.R., Goldstone, J.V., Imhoff, B.R., Stegeman, J.J., Hahn, M.E., and Hansen, J.M. (2013) Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free radical biology & medicine. 65:89-101
Aluru, N., Deak, K.L., Jenny, M.J., and Hahn, M.E. (2013) Developmental exposure to valproic acid alters the expression of microRNAs involved in neurodevelopment in zebrafish. Neurotoxicology and teratology. 40C:46-58
Williams, L.M., Timme-Laragy, A.R., Goldstone, J.V., McArthur, A.G., Stegeman, J.J., Smolowitz, R.M., and Hahn, M.E. (2013) Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS One. 8(10):e79574
Bainy, A.C., Kubota, A., Goldstone, J.V., Lille-Langøy, R., Karchner, S.I., Celander, M.C., Hahn, M.E., Goksøyr, A., and Stegeman, J.J. (2013) Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 142-143:447-457
Amemiya, C.T., Alfoldi, J., Lee, A.P., Fan, S., Philippe, H., MacCallum, I., Braasch, I., Manousaki, T., Schneider, I., Rohner, N., Organ, C., Chalopin, D., Smith, J.J., Robinson, M., Dorrington, R.A., Gerdol, M., Aken, B., Biscotti, M.A., Barucca, M., Baurain, D., Berlin, A.M., Blatch, G.L., Buonocore, F., Burmester, T., Campbell, M.S., Canapa, A., Cannon, J.P., Christoffels, A., de Moro, G., Edkins, A.L., Fan, L., Fausto, A.M., Feiner, N., Forconi, M., Gamieldien, J., Gnerre, S., Gnirke, A., Goldstone, J.V., Haerty, W., Hahn, M.E., Hesse, U., Hoffmann, S., Johnson, J., Karchner, S.I., Karaku, S., Lara, M., Levin, J.Z., Litman, G.W., Mauceli, E., Miyake, T., Mueller, M.G., Nelson, D.R., Nitsche, A., Olmo, E., Ota, T., Pallavicini, A., Panji, S., Picone, B., Ponting, C.P., Prohaska, S.J., Przybylski, D., Saha, N.R., Ravi, V., Ribeiro, F.J., Sauka-Spengler, T., Scapigliati, G., Searle, S.M.J., Sharpe, T., Simakov, O., Stadler, P.F., Stegeman, J.J., Sumiyama, K., Tabbaa, D., Tafer, H., Turner-Maier, J., van Heusden, P., White, S., Williams, L., Yandell, M., Brinkmann, H., Volff, J.N., Tabin, C.J., Shubin, N., Schartl, M., Jaffe, D.B., Postlethwait, J.H., Venkatesh, B., Palma, F.D., Lander, E.S., Meyer, A., and Lindblad-Toh, K. (2013) The African coelacanth genome provides insights into tetrapod evolution. Nature. 496:311-316
Fraccalvieri, D., Soshilov, A.A., Karchner, S.I., Franks, D.G., Pandini, A., Bonati, L., Hahn, M.E., and Denison, M.S. (2013) Comparative Analysis of Homology Models of the Ah Receptor Ligand Binding Domain: Verification of Structure–Function Predictions by Site-Directed Mutagenesis of a Nonfunctional Receptor. Biochemistry. 52(4):714-725
Jenny, M.J., Aluru, N., and Hahn, M.E. (2012) Effects of short-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on microRNA expression in zebrafish embryos. Toxicology and applied pharmacology. 264(2):262-273
Timme-Laragy, A.R., Karchner, S.I., Franks, D.G., Jenny, M.J., Harbeitner, R.C., Goldstone, J.V., McArthur, A.G., and Hahn, M.E. (2012) Nrf2b: novel zebrafish paralog of the oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). The Journal of biological chemistry. 287(7):4609-4627
Timme-Laragy, A.R., Karchner, S.I., and Hahn, M.E. (2012) Gene Knockdown by Morpholino-Modified Oligonucleotides in the Zebrafish (Danio rerio) Model: Applications for Developmental Toxicology. Methods in molecular biology (Clifton, N.J.). 889:51-71
Jönsson, M.E., Franks, D.G., Woodin, B.R., Jenny, M.J., Garrick, R.A., Behrendt, L., Hahn, M.E., and Stegeman, J.J. (2009) The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish. Chemico-biological interactions. 181(3):447-454
Jenny, M.J., Karchner, S., Franks, D., Woodin, B.W., Stegeman, J.J., and Hahn, M.E. (2009) Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin). Toxicological sciences : an official journal of the Society of Toxicology. 110(2):426-441
Matson, C.W., Clark, B.W., Jenny, M.J., Fleming, C.R., Hahn, M.E., and Di Giulio, R.T. (2008) Development of the morpholino gene knockdown technique in Fundulus heteroclitus: A tool for studying molecular mechanisms in an established environmental model. Aquatic toxicology (Amsterdam, Netherlands). 87(4):289-295
Evans, B.R., Karchner, S.I., Allan, L.L., Pollenz, R.S., Tanguay, R.L., Jenny, M.J., Sherr, D.H., and Hahn, M.E. (2008) Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. Molecular pharmacology. 73(2):387-398
Jönsson, M.E., Jenny, M.J., Woodin, B.R., Hahn, M.E., and Stegeman, J.J. (2007) Role of AHR2 in the Expression of Novel Cytochrome P450 1 Family Genes, Cell Cycle Genes, and Morphological Defects in Developing Zebrafish Exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 100(1):180-193
Hahn, M.E., Karchner, S.I., Evans, B.R., Franks, D.G., Merson, R.R., and Lapseritis, J.M. (2006) Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomics. Journal of experimental zoology. Part A, Ecological genetics and physiology. 305(9):693-706
Tarrant, A.M., Greytak, S.R., Callard, G.V., and Hahn, M.E. (2006) Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness. Journal of molecular endocrinology. 37(1):105-120
Karchner, S.I., Franks, D.G., and Hahn, M.E. (2005) AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of ahr1b and ahr2 genes. The Biochemical journal. 392:153-161
Evans, B.R., Karchner, S.I., Franks, D.G., and Hahn, M.E. (2005) Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: Structure, function, evolution, and AHR-dependent regulation in vivo. Archives of biochemistry and biophysics. 441(2):151-167
Hahn, M. E. (2005) Direct Submission of Mapping Data (Mark E. Hahn). Direct Submission of Mapping Data.
Reimers, M.J., Hahn, M.E., and Tanguay, R.L. (2004) Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V ADH genes but have distinct functional characteristics. The Journal of biological chemistry. 279(37):38303-38312
Hahn, M.E. (2002) Aryl hydrocarbon receptors: diversity and evolution. Chemico-biological interactions. 141(1-2):131-160
Andreasen, E.A., Hahn, M.E., Heideman, W., Peterson, R.E., and Tanguay, R.L. (2002) The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor. Molecular pharmacology. 62(2):234-249
Karchner, S.I., Franks, D.G., Powell, W.H., and Hahn, M.E. (2002) Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. The Journal of biological chemistry. 277(9):6949-6959
Hahn, M.E. (2001) Dioxin toxicology and the aryl hydrocarbon receptor: Insights from fish and other non-traditional models. Marine biotechnology (New York, N.Y.). 3:S224-S238
Powell, W.H. and Hahn, M.E. (2000) The evolution of aryl hydrocarbon signaling proteins: diversity of ARNT isoforms among fish species. Marine Environmental Research. 50(1-5):39-44