ZFIN ID: ZDB-LAB-151023-2
Parant Lab
PI/Director: Parant, John
Contact Person: Parant, John
URL: https://www.uab.edu/medicine/pharmacology/faculty/jparant
Address: University of Alabama at Birmingham Department of Pharmacology &Toxicology 1670 University Blvd. Volker Hall room 252 Birmingham AL 35294
Country: United States
Phone: 205-975-8469
Line Designation: uab

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Our broad interests are the impact of genomic instability on human disease. Presently we have two lab focuses: 1) The impact that defects in sister chromatid cohesion has on developmental disease and cancer predisposition; and 2) Understanding the regulation and mechanism of p53 tumor suppression. Much of our research has been facilitated by the development of a high throughput genome editing platform and in vivo live imaging of mitotic defects in mutant zebrafish embryos. Zebrafish is an ideal organism for this research due to the ability to combine powerful genetic approaches and the ability to monitor tumor predisposition.

Percival, Stefanie M. Graduate Student Thomas, Holly R. Research Staff

Wang, J., Thomas, H.R., Chen, Y., Percival, S.M., Waldrep, S.C., Ramaker, R.C., Thompson, R.G., Cooper, S.J., Chong, Z., Parant, J.M. (2022) Reduced sister chromatid cohesion acts as a tumor penetrance modifier. PLoS Genetics. 18:e1010341
Wang, J., Thomas, H.R., Li, Z., Yeo, N.C.F., Scott, H.E., Dang, N., Hossain, M.I., Andrabi, S.A., Parant, J.M. (2021) Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis. Cell Death & Disease. 12:659
Percival, S.M., Parant, J.M. (2016) Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo. Journal of visualized experiments : JoVE. (113)
Parant, J.M., Yeh, J.R. (2016) Approaches to Inactivate Genes in Zebrafish. Advances in experimental medicine and biology. 916:61-86
Percival, S.M., Thomas, H.R., Amsterdam, A., Carroll, A.J., Lees, J.A., Yost, H.J., Parant, J.M. (2015) Variations in sister chromatid cohesion dysfunction in esco2 mutant zebrafish reflects the phenotypic diversity of Roberts Syndrome. Disease models & mechanisms. 8(8):941-55
Crittenden, F., Thomas, H.R., Parant, J.M., Falany, C.N. (2015) Activity Suppression Behavior Phenotype in SULT4A1 Frameshift Mutant Zebrafish. Drug metabolism and disposition: the biological fate of chemicals. 43(7):1037-44
Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
Parant, J.M., George, S.A., Holden, J.A., and Yost, H.J. (2010) Genetic modeling of Li-Fraumeni syndrome in zebrafish. Disease models & mechanisms. 3(1-2):45-56
Parant, J.M., George, S.A., Pryor, R., Wittwer, C.T., and Yost, H.J. (2009) A rapid and efficient method of genotyping zebrafish mutants. Developmental dynamics : an official publication of the American Association of Anatomists. 238(12):3168-3174
Kwan, K.M., Fujimoto, E., Grabher, C., Mangum, B.D., Hardy, M.E., Campbell, D.S., Parant, J.M., Yost, H.J., Kanki, J.P., and Chien, C.B. (2007) The Tol2kit: A multisite gateway-based construction kit for Tol2 transposon transgenesis constructs. Developmental dynamics : an official publication of the American Association of Anatomists. 236(11):3088-3099