ZFIN Lab: Tokiharu Takahashi Lab

ZFIN ID: ZDB-LAB-150625-2

ZFIN ID: ZDB-LAB-150625-2

Tokiharu Takahashi Lab

PI/Director:	Takahashi, Tokiharu
Contact Person:	Takahashi, Tokiharu
Email:	Tokiharu.Takahashi@manchester.ac.uk
URL:
Address:	Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
Country:	United Kingdom
Phone:	+44 161 2755538
Fax:	+44 161 2755082
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Our laboratory is primarily interested in the interplay between genes, development and evolution. In particular, our interest centres on molecular mechanisms which lead to vertebrate novelties in relation to the large-scale genomic events at early vertebrate evolution. Currently, we are focusing on the genetic basis underlying the evolution of chordate craniofacial structure, as their emergence and evolution was certainly a critical step for the successful expansion of vertebrates.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Wang, H., Holland, P.W.H., Takahashi, T. (2019) Gene profiling of head mesoderm in early zebrafish development: insights into the evolution of cranial mesoderm. EvoDevo. 10:14

Page, D.J., Thuret, R., Venkatraman, L., Takahashi, T., Bentley, K., Herbert, S.P. (2019) Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Reports. 27:3139-3151.e5

Marlétaz, F., Firbas, P.N., Maeso, I., Tena, J.J., Bogdanovic, O., Perry, M., Wyatt, C.D.R., de la Calle-Mustienes, E., Bertrand, S., Burguera, D., Acemel, R.D., van Heeringen, S.J., Naranjo, S., Herrera-Ubeda, C., Skvortsova, K., Jimenez-Gancedo, S., Aldea, D., Marquez, Y., Buono, L., Kozmikova, I., Permanyer, J., Louis, A., Albuixech-Crespo, B., Le Petillon, Y., Leon, A., Subirana, L., Balwierz, P.J., Duckett, P.E., Farahani, E., Aury, J.M., Mangenot, S., Wincker, P., Albalat, R., Benito-Gutiérrez, È., Cañestro, C., Castro, F., D'Aniello, S., Ferrier, D.E.K., Huang, S., Laudet, V., Marais, G.A.B., Pontarotti, P., Schubert, M., Seitz, H., Somorjai, I., Takahashi, T., Mirabeau, O., Xu, A., Yu, J.K., Carninci, P., Martinez-Morales, J.R., Crollius, H.R., Kozmik, Z., Weirauch, M.T., Garcia-Fernàndez, J., Lister, R., Lenhard, B., Holland, P.W.H., Escriva, H., Gómez-Skarmeta, J.L., Irimia, M. (2018) Amphioxus functional genomics and the origins of vertebrate gene regulation. Nature. 564:64-70

Cetinkaya, A., Xiong, J.R., Vargel, İ., Kösemehmetoğlu, K., Canter, H.İ., Gerdan, Ö.F., Longo, N., Alzahrani, A., Camps, M.P., Taskiran, E.Z., Laupheimer, S., Botto, L.D., Paramalingam, E., Gormez, Z., Uz, E., Yuksel, B., Ruacan, Ş., Sağıroğlu, M.Ş., Takahashi, T., Reversade, B., Akarsu, N.A. (2016) Loss-of-Function Mutations in ELMO2 Cause Intraosseous Vascular Malformation by Impeding RAC1 Signaling. American journal of human genetics. 99(2):299-317