ZFIN Lab: Lengerke Lab

ZFIN ID: ZDB-LAB-131023-1

Lengerke Lab

PI/Director:	Lengerke, Claudia
Contact Person:	Konantz, Martina
Email:	melanie.neutzner@unibas.ch
URL:	http://biomedizin.unibas.ch
Address:	University Hospital Basel Department for Biomedicine Lab 201 Hebelstr. 20 CH-4031 Basel Switzerland
Country:	Switzerland
Phone:	+41 61 26 52381
Fax:
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

stem cells and hematopoiesis
xenotransplantation of human cells

LAB MEMBERS

Alghisi, Elisa Post-Doc	Konantz, Martina Post-Doc	Sauteur, Loïc Post-Doc
Müller, Joëlle Technical Staff	Hanns, Pauline	Schürch, Christoph

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Schmitt, A., Xu, W., Bucher, P., Grimm, M., Konantz, M., Horn, H., Zapukhlyak, M., Berning, P., Brändle, M., Jarboui, M.A., Schönfeld, C., Boldt, K., Rosenwald, A., Ott, G., Grau, M., Klener, P., Vockova, P., Lengerke, C., Lenz, G., Schulze-Osthoff, K., Hailfinger, S. (2021) Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL. Blood. 138:871-884

Sonay, A.Y., Kalyviotis, K., Yaganoglu, S., Unsal, A., Konantz, M., Teulon, C., Lieberwirth, I., Sieber, S., Jiang, S., Behzadi, S., Crespy, D., Landfester, K., Roke, S., Lengerke, C., Pantazis, P. (2021) Biodegradable Harmonophores for Targeted High-Resolution In Vivo Tumor Imaging. ACS nano. 15(3):4144-4154

Castro, C.N., Rosenzwajg, M., Carapito, R., Shahrooei, M., Konantz, M., Khan, A., Miao, Z., Groß, M., Tranchant, T., Radosavljevic, M., Paul, N., Stemmelen, T., Pitoiset, F., Hirschler, A., Nespola, B., Molitor, A., Rolli, V., Pichot, A., Faletti, L.E., Rinaldi, B., Friant, S., Mednikov, M., Karauzum, H., Aman, M.J., Carapito, C., Lengerke, C., Ziaee, V., Eyaid, W., Ehl, S., Alroqi, F., Parvaneh, N., Bahram, S. (2020) NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation. The Journal of experimental medicine. 217(12):

Schürch, C., Schaefer, T., Müller, J.S., Hanns, P., Arnone, M., Dumlin, A., Schärer, J., Sinning, I., Wild, K., Skokowa, J., Welte, K., Carapito, R., Bahram, S., Konantz, M., Lengerke, C. (2020) SRP54 mutations induce Congenital Neutropenia via dominant-negative effects on XBP1 splicing. Blood. 137(10):1340-1352

Huang, Y.L., Liang, C.Y., Ritz, D., Coelho, R., Septiadi, D., Estermann, M., Cumin, C., Rimmer, N., Schötzau, A., Núñez López, M., Fedier, A., Konantz, M., Vlajnic, T., Calabrese, D., Lengerke, C., David, L., Rothen-Rutishauser, B., Jacob, F., Heinzelmann-Schwarz, V. (2020) Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. eLIFE. 9:

Konantz, M., Schürch, C., Hanns, P., Müller, J.S., Sauteur, L., Lengerke, C. (2019) Modeling hematopoietic disorders in zebrafish. Disease models & mechanisms. 12(9)

Konantz, M., Müller, J.S., Lengerke, C. (2019) Zebrafish Xenografts for the In Vivo Analysis of Healthy and Malignant Human Hematopoietic Cells. Methods in molecular biology (Clifton, N.J.). 2017:205-217

Zizioli, D., Mione, M., Varinelli, M., Malagola, M., Bernardi, S., Alghisi, E., Borsani, G., Finazzi, D., Monti, E., Presta, M., Russo, D. (2018) Zebrafish disease models in hematology: Highlights on biological and translational impact. Biochimica et biophysica acta. Molecular basis of disease. 1865(3):620-633

Porta, F., Ehrsam, D., Lengerke, C., Meyer Zu Schwabedissen, H.E. (2018) Synthesis and characterization of a PDMS-PMOXA based polymersomes sensitive to MMP-9 for application in breast cancer. Molecular pharmaceutics. 15(11):4884-4897

Paatero, I., Sauteur, L., Lee, M., Lagendijk, A.K., Heutschi, D., Wiesner, C., Guzmán, C., Bieli, D., Hogan, B.M., Affolter, M., Belting, H.G. (2018) Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction. Nature communications. 9:3545

Jacob, F., Alam, S., Konantz, M., Liang, C.Y., Kohler, R.S., Everest-Dass, A.V., Huang, Y.L., Rimmer, N., Fedier, A., Schötzau, A., Lopez, M.N., Packer, N.H., Lengerke, C., Heinzelmann-Schwarz, V. (2018) Transition of Mesenchymal and Epithelial Cancer Cells Depends on α1-4 Galactosyltransferase-Mediated Glycosphingolipids. Cancer research. 78:2952-2965

Carapito, R., Konantz, M., Paillard, C., Miao, Z., Pichot, A., Leduc, M.S., Yang, Y., Bergstrom, K.L., Mahoney, D.H., Shardy, D.L., Alsaleh, G., Naegely, L., Kolmer, A., Paul, N., Hanauer, A., Rolli, V., Müller, J.S., Alghisi, E., Sauteur, L., Macquin, C., Morlon, A., Sancho, C.S., Amati-Bonneau, P., Procaccio, V., Mosca-Boidron, A.L., Marle, N., Osmani, N., Lefebvre, O., Goetz, J.G., Unal, S., Akarsu, N.A., Radosavljevic, M., Chenard, M.P., Rialland, F., Grain, A., Béné, M.C., Eveillard, M., Vincent, M., Guy, J., Faivre, L., Thauvin-Robinet, C., Thevenon, J., Myers, K., Fleming, M.D., Shimamura, A., Bottollier-Lemallaz, E., Westhof, E., Lengerke, C., Isidor, B., Bahram, S. (2017) Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features. The Journal of Clinical Investigation. 127(11):4090-4103

Sauteur, L., Affolter, M., Belting, H.G. (2017) Distinct and redundant functions of Esam and VE-cadherin during vascular morphogenesis. Development (Cambridge, England). 144(8):1554-1565

Wang, H., Schaefer, T., Konantz, M., Braun, M., Varga, Z., Paczulla, A.M., Reich, S., Jacob, F., Perner, S., Moch, H., Fehm, T.N., Kanz, L., Schulze-Osthoff, K., Lengerke, C. (2017) Prominent Oncogenic Roles of EVI1 in Breast Carcinoma. Cancer research. 77:2148-2160

von Mässenhausen, A., Sanders, C., Brägelmann, J., Konantz, M., Queisser, A., Vogel, W., Kristiansen, G., Duensing, S., Schröck, A., Bootz, F., Brossart, P., Kirfel, J., Lengerke, C., Perner, S. (2016) Targeting DDR2 in Head and Neck Squamous Cell Carcinoma with Dasatinib. International Journal of Cancer. 139(10):2359-69

Konantz, M., Alghisi, E., Müller, J.S., Lenard, A., Esain, V., Carroll, K.J., Kanz, L., North, T.E., Lengerke, C. (2016) Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence. The EMBO journal. 35(21):2315-2331

Lenard, A., Alghisi, E., Daff, H., Donzelli, M., McGinnis, C., Lengerke, C. (2016) Using zebrafish to model erythroid lineage toxicity and regeneration. Haematologica. 101(5):e164-7

Kanz, D., Konantz, M., Alghisi, E., North, T.E., Lengerke, C. (2016) Endothelial-to-hematopoietic transition: Notch-ing vessels into blood. Annals of the New York Academy of Sciences. 1370(1):97-108

Schaefer, T., Wang, H., Mir, P., Konantz, M., Pereboom, T.C., Paczulla, A.M., Merz, B., Fehm, T., Perner, S., Rothfuss, O.C., Kanz, L., Schulze-Osthoff, K., Lengerke, C. (2015) Molecular and functional interactions between AKT and SOX2 in breast carcinoma. Oncotarget. 6:43540-56

Ittig, S.J., Schmutz, C., Kasper, C.A., Amstutz, M., Schmidt, A., Sauteur, L., Vigano, M.A., Low, S.H., Affolter, M., Cornelis, G.R., Nigg, E.A., Arrieumerlou, C. (2015) A bacterial type III secretion-based protein delivery tool for broad applications in cell biology. The Journal of cell biology. 211:913-31

Dooley, C.M., Schwarz, H., Mueller, K.P., Mongera, A., Konantz, M., Neuhauss, S.C., Nüsslein-Volhard, C., and Geisler, R. (2013) Slc45a2 and V-ATPase are regulators of melanosomal pH homeostasis in zebrafish, providing a mechanism for human pigment evolution and disease. Pigment cell & melanoma research. 26(2):205-217

McKinney-Freeman, S., Cahan, P., Li, H., Lacadie, S.A., Huang, H.T., Curran, M., Loewer, S., Naveiras, O., Kathrein, K.L., Konantz, M., Langdon, E.M., Lengerke, C., Zon, L.I., Collins, J.J., and Daley, G.Q. (2012) The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell. 11(5):701-714

Konantz, M., Balci, T.B., Hartwig, U.F., Dellaire, G., André, M.C., Berman, J.N., and Lengerke, C. (2012) Zebrafish xenografts as a tool for in vivo studies on human cancer. Annals of the New York Academy of Sciences. 1266(1):124-137

Lengerke, C., and Daley, G.Q. (2012) Caudal genes in blood development and leukemia. Annals of the New York Academy of Sciences. 1266(1):47-54

Lengerke, C., Wingert, R., Beeretz, M., Grauer, M., Schmidt, A.G., Konantz, M., Daley, G.Q., and Davidson, A.J. (2011) Interactions between Cdx genes and retinoic acid modulate early cardiogenesis. Developmental Biology. 354(1):134-142

Geisler, R., Rauch, G.J., Geiger-Rudolph, S., Albrecht, A., van Bebber, F., Berger, A., Busch-Nentwich, E., Dahm, R., Dekens, M.P., Dooley, C., Elli, A.F.,Gehring, I., Geiger, H., Geisler, M., Glaser, S., Holley, S., Huber, M., Kerr, A., Kirn, A., Knirsch, M., Konantz, M., Kuchler, A.M., Maderspacher, F., Neuhauss, S.C., Nicolson, T., Ober, E.A., Praeg, E., Ray, R., Rentzsch, B., Rick, J.M., Rief, E., Schauerte, H.E., Schepp, C.P., Schonberger, U., Schonthaler, H.B., Seiler, C., Sidi, S., Söllner, C., Wehner, A., Weiler, C., Nüsslein-Volhard, C. (2007) Large-scale mapping of mutations affecting zebrafish development. BMC Genomics. 8(1):11