ZFIN ID: ZDB-LAB-130104-2
de Jong Lab
PI/Director: de Jong, Jill
Contact Person: Marin, Wilfredo
Email: wmarin@peds.bsd.uchicago.edu
URL: http://kidscancer.uchicago.edu/page/jill-de-jong-md-phd
Address: Department of Pediatrics, Hematology/Oncology University of Chicago Knapp Center for Biomedical Discovery 5230 900 East 57th Street Chicago, IL 60637 USA
Country: United States
Phone: (773) 795-2230
Fax: (773) 834-1329
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
My lab is interested in the genes that regulate normal HSC function in the bone marrow, and studying whether those genes may contribute to the development of leukemia when their expression is abnormal. We utilize the zebrafish animal model as a unique discovery mechanism to uncover new genetic regulators of HSCs, and thereby new genes important for causing leukemia and other hematopoietic malignancies. Identifying these genes will open the door to understanding normal HSC function in vivo and after transplantation, and more importantly, will provide new insights into the mechanisms leading to the development of leukemia and potentially new targets for the treatment of leukemia.


LAB MEMBERS
McConnell, Sean Post-Doc Marin, Wilfredo Technical Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O. (2023) Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Scientific Reports. 13:77777777
Wcisel, D.J., Dornburg, A., McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O., Litman, G.W., Yoder, J.A. (2022) A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors. Immunogenetics. 75(1):53-69
DiNapoli, S.E., Martinez-McFaline, R., Gribbin, C.K., Wrighton, P.J., Balgobin, C.A., Nelson, I., Leonard, A., Maskin, C.R., Shwartz, A., Quenzer, E.D., Mailhiot, D., Kao, C., McConnell, S.C., de Jong, J.L.O., Goessling, W., Houvras, Y. (2020) Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic acids research. 48(7):e38
de Jong, J.L.O. (2019) Splicing up hematopoietic development. Blood. 133:770-771
Baeten, J.T., Waarts, M.R., Pruitt, M.M., Chan, W.C., Andrade, J., de Jong, J.L.O. (2019) The side population enriches for leukemia propagating cell activity and Wnt pathway expression in zebrafish acute lymphoblastic leukemia. Haematologica. 104(7):1388-1395
Baeten, J.T., de Jong, J.L.O. (2018) Genetic Models of Leukemia in Zebrafish. Frontiers in cell and developmental biology. 6:115
Pruitt, M.M., Marin, W., Waarts, M.R., de Jong, J.L.O. (2017) Isolation of the Side Population in Myc-induced T-cell Acute Lymphoblastic Leukemia in Zebrafish. Journal of visualized experiments : JoVE. (123)
McConnell, S.C., Hernandez, K.M., Wcisel, D.J., Kettleborough, R.N., Stemple, D.L., Yoder, J.A., Andrade, J., de Jong, J.L. (2016) Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. Proceedings of the National Academy of Sciences of the United States of America. 113(34):E5014-23
Dirscherl, H., McConnell, S.C., Yoder, J.A., de Jong, J.L. (2014) The MHC class I genes of zebrafish. Developmental and comparative immunology. 46(1):11-23
McConnell, S.C., Restaino, A.C., and de Jong, J.L. (2014) Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish. Immunogenetics. 66(3):199-213
Ganis, J.J., Hsia, N., Trompouki, E., de Jong, J.L., Dibiase, A., Lambert, J.S., Jia, Z., Sabo, P.J., Weaver, M., Sandstrom, R., Stamatoyannopoulos, J.A., Zhou, Y., and Zon, L.I. (2012) Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Developmental Biology. 366(2):185-194
de Jong, J.L., and Zon, L.I. (2012) Histocompatibility and Hematopoietic Transplantation in the Zebrafish. Advances in hematology. 2012:282318
de Jong, J.L., Burns, C.E., Chen, A.T., Pugach, E., Mayhall, E.A., Smith, A.C., Feldman, H.A., Zhou, Y., and Zon, L.I. (2011) Characterization of immune-matched hematopoietic transplantation in zebrafish. Blood. 117(16):4234-42
de Jong, J.L., Davidson, A.J., Wang, Y., Palis, J., Opara, P., Pugach, E., Daley, G.Q., and Zon, L.I. (2010) Interaction of retinoic acid and scl controls primitive blood development. Blood. 116(2):201-209
Smith, A.C., Raimondi, A.R., Salthouse, C.D., Ignatius, M.S., Blackburn, J.S., Mizgirev, I.V., Storer, N.Y., de Jong, J.L., Chen, A.T., Zhou, Y., Revskoy, S., Zon, L.I., and Langenau, D.M. (2010) High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Blood. 115(16):3296-3303
Paik, E.J., de Jong, J.L., Pugach, E., Opara, P., and Zon, L.I. (2010) A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis. Zebrafish. 7(1):61-68
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