Genomic Features

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Statement of Research Interest

The laboratory focuses on understanding the developmental specification of hematopoietic stem cells and vascular smooth muscle cells. We are also interested in understanding the molecular basis of specific B cell leukemias, and the connection of these mechanisms to developmental programming.

Lab Members

Coffey, Elizabeth Post-Doc	Williamson, McLean Graduate Student	Kelley, Clair Research Staff
Simpson, Dana

Zebrafish Publications of lab members

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• Rothschild, S.C., Lai, G., Tombes, R.M., Clements, W.K. (2023) Constitutively active CaMKII Drives B lineage acute lymphoblastic leukemia/lymphoma in tp53 mutant zebrafish. PLoS Genetics. 19:e1011102e1011102
• Coffey, E.C., Astumian, M., Alrowaished, S.S., Schaffer, C., Henry, C.A. (2021) Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix. Journal of developmental biology. 9(4):
• da Bandeira, D.S., Clements, W.K. (2020) MYC'xing it up: zebrafish B ALL models provide insight into MYC-driven disease and relapse. Oncotarget. 11:2372-2374
• Koirala, S., Klein, J., Zheng, Y., Glenn, N.O., Eisemann, T., Fon Tacer, K., Miller, D.J., Kulak, O., Lu, M., Finkelstein, D.B., Neale, G., Tillman, H., Vogel, P., Strand, D.W., Lum, L., Brautigam, C.A., Pascal, J.M., Clements, W.K., Potts, P.R. (2020) Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase. Cell Reports. 32:107922
• Damm, E.W., Clements, W.K. (2017) Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nature cell biology. 19(5):457-467
• Genthe, J.R., Clements, W.K. (2017) R-spondin-1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways. Development (Cambridge, England). 144(4):590-600
• Genthe, J.R., Min, J., Farmer, D.M., Shelat, A.A., Grenet, J.A., Lin, W., Finkelstein, D.B., Vrijens, K., Chen, T., Guy, R.K., Clements, W.K., Roussel, M.F. (2017) Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway. ACS Chemical Biology. 12(9):2436-2447
• Kim, A.D., Melick, C.H., Clements, W.K., Stachura, D.L., Distel, M., Panáková, D., MacRae, C., Mork, L.A., Crump, J.G., Traver, D. (2014) Discrete Notch signaling requirements in the specification of hematopoietic stem cells. The EMBO journal. 33(20):2363-73
• Lee, Y., Manegold, J.E., Kim, A.D., Pouget, C., Stachura, D.L., Clements, W.K., Traver, D. (2014) FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nature communications. 5:5583
• Clements, W.K., and Traver, D. (2012) Fish pharming: zebrafish antileukemia screening. Blood. 119(24):5614-5615

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