ZFIN ID: ZDB-LAB-121129-1
Chunyue Yin Lab
PI/Director: Yin, Chunyue
Contact Person: Yin, Chunyue
Email: chunyue.yin@cchmc.org
URL: http://www.cincinnatichildrens.org/research/divisions/g/gastroenterology/labs/yin/default/
Address: Division of Gastroenterology, hepatology and Nutrition Cincinnati Children's Hospital Medical Center Location S, Suite S6.510 240 Albert Sabin Way Cincinnati, OH 45229
Country: United States
Phone: 513-803-8096
Line Designation: ci

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The long-term goal in the Yin lab is to understand the molecular and cellular mechanisms underlying liver development, regeneration and disease pathogenesis. Our projects use a combination of genetic, molecular, embryology, biochemical, and cell biological approaches in the zebrafish model to address questions related to liver biology.

Currently, there are two main focuses in the lab. The first one is to delineate the regulation of hepatic stellate cells, the key cell type responsible for liver fibrosis, during liver development and injury. The second one is to understand the cell biology of hepatic biliary cells in the zebrafish models of biliary diseases.

Ellis, Jillian Research Staff

Karolczak, S., Deshwar, A.R., Aristegui, E., Kamath, B.M., Lawlor, M.W., Andreoletti, G., Volpatti, J.R., Ellis, J.L., Yin, C., Dowling, J.J. (2023) Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy. The Journal of Clinical Investigation. 133(18):
Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
Pham, D.H., Kudira, R., Xu, L., Valencia, C.A., Ellis, J.L., Shi, T., Evason, K.J., Osuji, I., Matuschek, N., Pfuher, L., Mullen, M., Mohanty, S.K., Husami, A., Bull, L.N., Zhang, K., Wali, S., Yin, C., Miethke, A. (2021) Deleterious variants in ABCC12 are detected in idiopathic chronic cholestasis and cause intrahepatic bile duct loss in model organisms: ABCC12 pathogenic variants lead to cholestasis. Gastroenterology. 161(1):287-300.e16
Shwartz, A., Goessling, W., Yin, C. (2019) Macrophages in Zebrafish Models of Liver Diseases. Frontiers in immunology. 10:2840
DeRossi, C., Bambino, K., Morrison, J., Sakarin, I., Villacorta-Martin, C., Zhang, C., Ellis, J.L., Fiel, M.I., Ybanez, M., Lee, Y.A., Huang, K.L., Yin, C., Sakaguchi, T.F., Friedman, S.L., Villanueva, A., Chu, J. (2019) Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans. Hepatology (Baltimore, Md.). 70(6):2107-2122
Pham, D.H., Yin, C. (2019) Zebrafish as a Model to Study Cholestatic Liver Diseases. Methods in molecular biology (Clifton, N.J.). 1981:273-289
Williams, M.L.K., Sawada, A., Budine, T., Yin, C., Gontarz, P., Solnica-Krezel, L. (2018) Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes. Nature communications. 9:1319
Ellis, J.L., Bove, K.E., Schuetz, E.G., Leino, D., Valencia, C.A., Schuetz, J.D., Miethke, A., Yin, C. (2017) Zebrafish abcb11b mutant reveals novel strategies to restore bile excretion impaired by bile salt export pump deficiency. Hepatology (Baltimore, Md.). 67(4):1531-1545
Pham, D.H., Zhang, C., Yin, C. (2017) Using zebrafish to model liver diseases-Where do we stand?. Current pathobiology reports. 5:207-221
Yang, Q., Yan, C., Yin, C., Gong, Z. (2017) Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma. Cellular and molecular gastroenterology and hepatology. 3:484-499
Zhang, C., Ellis, J.L., Yin, C. (2016) Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish. Disease models & mechanisms. 9(11):1383-1396
Tsedensodnom, O., Vacaru, A.M., Howarth, D.L., Yin, C., and Sadler, K.C. (2013) Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease. Disease models & mechanisms. 6(5):1213-26
Hochgreb-H├Ągele, T., Yin, C., Koo, D.E., Bronner, M.E., and Stainier, D.Y. (2013) Laminin beta1a controls distinct steps during the establishment of digestive organ laterality. Development (Cambridge, England). 140(13):2734-2745
Howarth, D.L., Yin, C., Yeh, K., and Sadler, K.C. (2013) Defining hepatic dysfunction parameters in two models of Fatty liver disease in zebrafish larvae. Zebrafish. 10(2):199-210
Yin, C., Evason, K.J., Maher, J.J., and Stainier, D.Y. (2012) The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver. Hepatology (Baltimore, Md.). 56(5):1958-1970
Delous, M., Yin, C., Shin, D., Ninov, N., Debrito Carten, J., Pan, L., Ma, T.P., Farber, S.A., Moens, C.B., and Stainier, D.Y. (2012) sox9b Is a Key Regulator of Pancreaticobiliary Ductal System Development. PLoS Genetics. 8(6):e1002754
Yin, C., Kikuchi, K., Hochgreb, T., Poss, K.D., and Stainier, D.Y. (2010) Hand2 Regulates Extracellular Matrix Remodeling Essential for Gut-Looping Morphogenesis in Zebrafish. Developmental Cell. 18(6):973-984
Yin, C., Ciruna, B., and Solnica-Krezel, L. (2009) Convergence and extension movements during vertebrate gastrulation. Current topics in developmental biology. 89:163-192
Yin, C., Kiskowski, M., Pouille, P.A., Farge, E., and Solnica-Krezel, L. (2008) Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulation. The Journal of cell biology. 180(1):221-232
Yin, C., and Solnica-Krezel, L. (2007) Convergence and extension movements affect dynamic notochord-somite interactions essential for zebrafish slow muscle morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(10):2742-2756
Yin, C., and Solnica-Krezel, L. (2007) Convergence and extension movements mediate the specification and fate maintenance of zebrafish slow muscle precursors. Developmental Biology. 304(1):141-155
Mendelsohn, B.A., Yin, C., Johnson, S.L., Wilm, T.P., Solnica-Krezel, L., and Gitlin, J.D. (2006) Atp7a determines a hierarchy of copper metabolism essential for notochord development. Cell Metabolism. 4(2):155-162
Lin, F., Sepich, D.S., Chen, S., Topczewski, J., Yin, C., Solnica-Krezel, L., and Hamm, H. (2005) Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. The Journal of cell biology. 169(5):777-787
Marlow, F., Gonzalez, E.M., Yin, C., Rojo, C., and Solnica-Krezel, L. (2004) No tail co-operates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish. Development (Cambridge, England). 131(1):203-216