ZFIN ID: ZDB-LAB-100713-1
Dong Lab
PI/Director: Dong, P. Duc
Contact Person: Schuman, Esther
Email: eschuman@sanfordburnham.org
Address: Sanford-Burnham Medical Research Institute 10901 North Torrey Pines Rd. | Building 10, Room 1401 La Jolla, CA 92037 USA
Country: United States
Phone: 858.795.5258
Line Designation: sid

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Through developmental studies, our lab is primarily focused on understanding progenitor biology. Our goal to decipher progenitor biology to the point that will allow us to genetically or pharmacologically manipulate differentiation, in vivo, which will undoubtedly advance the field of regenerative medicine. We also aim to gain insight into diseases associated progenitor dysfunction and their potential therapies. Using the zebrafish vertebrate model system, we are currently researching how transcription and signaling factors regulate progenitors of the pancreas, liver, and intestine.

Gates, Keith Post-Doc Lancman, Joseph Post-Doc Zhang, Danhua Graduate Student
Zhou, Haowen Technical Staff Schuman, Esther Administrative Staff

Zhao, C., Matalonga, J., Lancman, J.J., Liu, L., Xiao, C., Kumar, S., Gates, K.P., He, J., Graves, A., Huisken, J., Azuma, M., Lu, Z., Chen, C., Ding, B.S., Dong, P.D.S. (2022) Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201097119e2201097119
Ai, X., Ye, Z., Xiao, C., Zhong, J., Lancman, J.J., Chen, X., Pan, X., Yang, Y., Zhou, L., Wang, X., Shi, H., Zhang, D., Yao, Y., Cao, D., Zhao, C. (2022) Clinically relevant orthotopic xenograft models of patient-derived glioblastoma in zebrafish. Disease models & mechanisms. 15(4)
Zhao, C., Lancman, J.J., Yang, Y., Gates, K.P., Cao, D., Barske, L., Matalonga, J., Pan, X., He, J., Graves, A., Huisken, J., Chen, C., Dong, P.D.S. (2021) Intrahepatic cholangiocyte regeneration from an Fgf-dependent extrahepatic progenitor niche in a zebrafish model of Alagille Syndrome. Hepatology (Baltimore, Md.). 75(3):567-583
Xia, Z.J., Zeng, X.I., Tambe, M., Ng, B.G., Dong, P.D.S., Freeze, H.H. (2021) A Dominant Heterozygous Mutation in COG4 Causes Saul-Wilson Syndrome, a Primordial Dwarfism, and Disrupts Zebrafish Development via Wnt Signaling. Frontiers in cell and developmental biology. 9:720688
Cheng, J., Tsuda, M., Okolotowicz, K., Dwyer, M., Bushway, P.J., Colas, A.R., Lancman, J.J., Schade, D., Perea-Gil, I., Bruyneel, A.A.N., Lee, J., Vadgama, N., Quach, J., McKeithan, W.L., Biechele, T.L., Wu, J.C., Moon, R.T., Si Dong, P.D., Karakikes, I., Cashman, J.R., Mercola, M. (2021) Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness. Cell chemical biology. 28:625-635.e5
Geusz, R.J., Wang, A., Chiou, J., Lancman, J.J., Wetton, N., Kefalopoulou, S., Wang, J., Qui, Y., Yan, J., Aylward, A., Ren, B., Dong, P.D.S., Gaulton, K.J., Sander, M. (2021) Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. eLIFE. 10
Fabian, P., Tseng, K.C., Smeeton, J., Lancman, J.J., Dong, P.D.S., Cerny, R., Crump, J.G. (2020) Lineage analysis reveals an endodermal contribution to the vertebrate pituitary. Science (New York, N.Y.). 370:463-467
Monestime, C.M., Taibi, A., Gates, K.P., Jiang, K., Sirotkin, H.I. (2019) CoRest1 regulates neurogenesis in a stage-dependent manner. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(10):918-930
Helker, C.S.M., Mullapudi, S.T., Mueller, L.M., Preussner, J., Tunaru, S., Skog, O., Kwon, H.B., Kreuder, F., Lancman, J.J., Bonnavion, R., Dong, P.D.S., Looso, M., Offermanns, S., Korsgren, O., Spagnoli, F.M., Stainier, D.Y.R. (2019) Whole organism small molecule screen identifies novel regulators of pancreatic endocrine development. Development (Cambridge, England). 146(14):
Berenguer, M., Lancman, J.J., Cunningham, T.J., Duc Si Dong, P., Duester, G. (2018) Mouse but not zebrafish requires retinoic acid for control of neuromesodermal progenitors and body axis extension. Developmental Biology. 441(1):127-131
Cunningham, T.J., Lancman, J.J., Berenguer, M., Dong, P.D.S., Duester, G. (2018) Genomic Knockout of Two Presumed Forelimb Tbx5 Enhancers Reveals They Are Nonessential for Limb Development. Cell Reports. 23:3146-3151
Zhang, D., Gates, K.P., Barske, L., Wang, G., Lancman, J.J., Zeng, X.I., Groff, M., Wang, K., Parsons, M.J., Crump, J.G., Dong, P.D.S. (2017) Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nature communications. 8:769
Zhang, D.H., Zhou, E.X., Yang, Z.L. (2017) Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae. PLoS One. 12:e0176927
Hockman, D., Burns, A., Schlosser, G., Gates, K.P., Jevans, B., Mongera, A., Fisher, S., Unlu, G., Knapik, E.W., Kaufman, C.K., Mosimann, C., Zon, L.I., Lancman, J.J., Dong, P.D., Lickert, H., Tucker, A.S., Baker, C.V. (2017) Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. eLIFE. 6
Han, T., Yang, C.S., Chang, K.Y., Zhang, D., Imam, F.B., Rana, T.M. (2016) Identification of novel genes and networks governing hematopoietic stem cell development. EMBO reports. 17(12):1814-1828
Liu, C., Gates, K.P., Fang, L., Amar, M.J., Schneider, D.A., Geng, H., Huang, W., Kim, J., Pattison, J., Zhang, J., Witztum, J.L., Remaley, A.T., Dong, P.D., Miller, Y.I. (2015) Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. Disease models & mechanisms. 8(8):989-98
Zhang, D., Golubkov, V.S., Han, W., Correa, R.G., Zhou, Y., Lee, S., Strongin, A.Y., Dong, P.D. (2014) Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival. Developmental Biology. 395(1):96-110
Lin, N., Chang, K.Y., Li, Z., Gates, K., Rana, Z.A., Dang, J., Zhang, D., Han, T., Yang, C.S., Cunningham, T.J., Head, S.R., Duester, G., Dong, P.D., and Rana, T.M. (2014) An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment. Molecular Cell. 53(6):1005-1019
Lancman, J.J., Zvenigorodsky, N., Gates, K.P., Zhang, D., Solomon, K., Humphrey, R.K., Kuo, T., Setiawan, L., Verkade, H., Chi, Y.I., Jhala, U.S., Wright, C.V., Stainier, D.Y., and Dong, P.D. (2013) Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development (Cambridge, England). 140(13):2669-2679
Golubkov, V.S., Chekanov, A.V., Cieplak, P., Aleshin, A.E., Chernov, A.V., Zhu, W., Radichev, I.A., Zhang, D., Dong, P.D., and Strongin, A.Y. (2010) The Wnt/planar cell polarity (PCP) protein tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase (MT1-MMP): implications in cancer and embryogenesis. The Journal of biological chemistry. 285(46):35740-35749
Anderson, R.M., Bosch, J.A., Goll, M.G., Hesselson, D., Dong, P.D., Shin, D., Chi, N.C., Shin, C.H., Schlegel, A., Halpern, M., and Stainier, D.Y. (2009) Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Developmental Biology. 334(1):213-223
Munson, C., Huisken, J., Bit-Avragim, N., Kuo, T., Dong, P.D., Ober, E.A., Verkade, H., Abdelilah-Seyfried, S., and Stainier, D.Y. (2008) Regulation of neurocoel morphogenesis by Pard6gammab. Developmental Biology. 324(1):41-54
Noël, E.S., Casal-Sueiro, A., Busch-Nentwich, E., Verkade, H., Dong, P.D., Stemple, D.L., and Ober, E.A. (2008) Organ-specific requirements for Hdac1 in liver and pancreas formation. Developmental Biology. 322(2):237-250
Dong, P.D., Provost, E., Leach, S.D., and Stainier, D.Y. (2008) Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas. Genes & Development. 22(11):1445-1450
Dong, P.D., Munson, C.A., Norton, W., Crosnier, C., Pan, X., Gong, Z., Neumann, C.J., and Stainier, D.Y. (2007) Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nature Genetics. 39(3):397-402
Ng, A.N., de Jong-Curtain, T.A., Mawdsley, D.J., White, S.J., Shin, J., Appel, B., Dong, P.D., Stainier, D.Y., and Heath, J.K. (2005) Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Developmental Biology. 286(1):114-135
Field, H.A., Dong, P.D., Beis, D., and Stainier, D.Y. (2003) Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology. 261(1):197-208