ZFIN Lab: Whitmore Lab

ZFIN ID: ZDB-LAB-060818-2

Whitmore Lab

PI/Director:	Whitmore, David
Co-PI / Senior Researcher:	Tamai, Takako Katherine
Contact Person:	Tamai, Takako Katherine
Email:	d.whitmore@ucl.ac.uk
URL:	http://www.ucl.ac.uk/cdb/research/whitmore/lab
Address:	University College London Centre for Cell and Molecular Dynamics Department of Cell and Developmental Biology 21 University Street London, WC1E 6DE
Country:	United Kingdom
Phone:	00 44 (0) 20 7679 6132
Fax:	00 44 (0) 20 7679 7349
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Laranjeiro, Ricardo Graduate Student

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Fong, C.K., Hearn, T., Webb, S.E., Frøland Steindal, I.A., Miller, A.L., Whitmore, D. (2021) Daily rhythms in heartbeat rate are intrinsic to the zebrafish heart. Current biology : CB. 31:R239-R240

Kroll, F., Powell, G.T., Ghosh, M., Gestri, G., Antinucci, P., Hearn, T.J., Tunbak, H., Lim, S., Dennis, H.W., Fernandez, J.M., Whitmore, D., Dreosti, E., Wilson, S.W., Hoffman, E.J., Rihel, J. (2021) A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes. eLIFE. 10:

Steindal, I.A.F., Whitmore, D. (2020) Zebrafish Circadian Clock Entrainment and the Importance of Broad Spectral Light Sensitivity. Frontiers in Physiology. 11:1002

Mosser, E.A., Chiu, C.N., Tamai, T.K., Hirota, T., Li, S., Hui, M., Wang, A., Singh, C., Giovanni, A., Kay, S.A., Prober, D.A. (2019) Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen. Scientific Reports. 9:12405

Frøland Steindal, I.A., Whitmore, D. (2019) Circadian Clocks in Fish-What Have We Learned so far?. Biology. 8(1)

Frøland Steindal, I.A., Beale, A., Yamamoto, Y., Whitmore, D. (2018) Development of the Astyanax mexicanus circadian clock and non-visual light responses. Developmental Biology. 441(2):345-354

Laranjeiro, R., Tamai, T.K., Letton, W., Hamilton, N., Whitmore, D. (2018) Circadian Clock Synchronization of the Cell Cycle in Zebrafish Occurs through a Gating Mechanism Rather Than a Period-phase Locking Process. Journal of biological rhythms. 33(2):137-150

Davies, W.I., Tamai, T.K., Zheng, L., Fu, J.K., Rihel, J., Foster, R.G., Whitmore, D., Hankins, M.W. (2015) An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function. Genome research. 25(11):1666-79

Heussen, R., Whitmore, D. (2015) The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock. Computational and Mathematical Methods in Medicine. 2015:254979

Laranjeiro, R., Whitmore, D. (2014) Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation. Development (Cambridge, England). 141(13):2644-56

Moore, H.A., and Whitmore, D. (2014) Circadian rhythmicity and light sensitivity of the zebrafish brain. PLoS One. 9(1):e86176

Peyric, E., Moore, H.A., and Whitmore, D. (2013) Circadian clock regulation of the cell cycle in the zebrafish intestine. PLoS One. 8(8):e73209

Laranjeiro, R., Tamai, T.K., Peyric, E., Krusche, P., Ott, S., and Whitmore, D. (2013) Cyclin-dependent kinase inhibitor p20 controls circadian cell-cycle timing. Proceedings of the National Academy of Sciences of the United States of America. 110(17):6835-40

Tamai, T.K., Young, L.C., Cox, C.A., and Whitmore, D. (2012) Light acts on the zebrafish circadian clock to suppress rhythmic mitosis and cell proliferation. Journal of biological rhythms. 27(3):226-236

Davies, W.I., Zheng, L., Hughes, S., Tamai, T.K., Turton, M., Halford, S., Foster, R.G., Whitmore, D., and Hankins, M.W. (2011) Functional diversity of melanopsins and their global expression in the teleost retina. Cellular and molecular life sciences : CMLS. 68(24):4115-32

Downey, M.J., Jeziorska, D.M., Ott, S., Tamai, T.K., Koentges, G., Vance, K.W., and Bretschneider, T. (2011) Extracting fluorescent reporter time courses of cell lineages from high-throughput microscopy at low temporal resolution. PLoS One. 6(12):e27886

Dekens, M.P., and Whitmore, D. (2008) Autonomous onset of the circadian clock in the zebrafish embryo. The EMBO journal. 27(20):2757-2765

Tamai, T.K., Young, L.C., and Whitmore, D. (2007) Light signaling to the zebrafish circadian clock by Cryptochrome 1a. Proceedings of the National Academy of Sciences of the United States of America. 104(37):14712-14717

Carr, A.J., Tamai, T.K., Young, L.C., Ferrer, V., Dekens, M.P., and Whitmore, D. (2006) Light reaches the very heart of the zebrafish clock. Chronobiology International. 23(1):91-100

Tamai, T.K., Carr, A.J., and Whitmore, D. (2005) Zebrafish circadian clocks: cells that see light. Biochemical Society transactions. 33:962-966

Carr, A.J., and Whitmore, D. (2005) Imaging of single light-responsive clock cells reveals fluctuating free-running periods. Nature cell biology. 7(3):319-321

Vallone, D., Gondi, S.B., Whitmore, D., and Foulkes, N.S. (2004) E-box function in a period gene repressed by light. Proceedings of the National Academy of Sciences of the United States of America. 101(12):4106-4111

Tamai, T.K., Vardhanabhuti, V., Foulkes, N.S., and Whitmore, D. (2004) Early embryonic light detection improves survival. Current biology : CB. 14(3):R104-105

Dekens, M.P.S., Santoriello, C., Vallone, D., Grassi, G., Whitmore, D., and Foulkes, N.S. (2003) Light regulates the cell cycle in zebrafish. Current biology : CB. 13(23):2051-2057

Moutsaki, P., Whitmore, D., Bellingham, J., Sakamoto, K., David-Gray, Z.K., and Foster, R.G. (2003) Teleost multiple tissue (tmt) opsin: a candidate photopigment regulating the peripheral clocks of zebrafish?. Brain research. Molecular brain research. 112(1-2):135-145

Tamai, T.K., Vardhanabhuti, V., Arthur, S., Foulkes, N.S., and Whitmore, D. (2003) Flies and fish: birds of a feather. Journal of neuroendocrinology. 15(4):344-349

Bellingham, J., Whitmore, D., Philp, A.R., Wells, D.J., and Foster, R.G. (2002) Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position. Brain research. Molecular brain research. 107(2):128-136

Whitmore, D., Cermakian, N., Crosio, C., Foulkes, N.S., Pando, M.P., Travnickova, Z., and Sassone-Corsi, P. (2000) A clockwork organ. Biological chemistry. 381(9-10):793-800

Cermakian, N., Whitmore, D., Foulkes, N.S., and Sassone-Corsi, P. (2000) Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function. Proceedings of the National Academy of Sciences of the United States of America. 97(8):4339-4344

Whitmore, D., Foulkes, N.S., and Sassone-Corsi, P. (2000) Light acts directly on organs and cells in culture to set the vertebrate circadian clock. Nature. 404(6773):87-91

Cermakian, N., Whitmore, D., Foulkes, N.S., and Sassone-Corsi, P. (2000) Independent peripheral clocks and direct light entrainment within the zebrafish circadian system. Journal of molecular medicine (Berlin, Germany). 78(7):B46

Whitmore, D., Foulkes, N.S., Strähle, U., and Sassone-Corsi, P. (1998) Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators. Nature Neuroscience. 1(8):701-707