ZFIN Lab: E. Elizabeth Patton Lab

ZFIN ID: ZDB-LAB-060818-1

E. Elizabeth Patton Lab

PI/Director:	Patton, E. Elizabeth
Contact Person:	Patton, E. Elizabeth
Email:	e.patton@hgu.mrc.ac.uk
URL:	http://www.ecrc.mcm.ed.ac.uk
Address:	Edinburgh Cancer Research Centre The University of Edinburgh Cancer Research UK Building Crewe Road South Edinburgh, Scotland, EH4 2XR United Kingdom
Country:	United Kingdom
Phone:	+44 (0) 131 777 3573
Fax:	+44 (0) 131 777 3583
Line Designation:	ue

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 7 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Brombin, Alessandro Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Travnickova, J., Muise, S., Wojciechowska, S., Brombin, A., Zeng, Z., Young, A.I.J., Wyatt, C., Patton, E.E. (2022) Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish. Disease models & mechanisms. 15(9):

Brunsdon, H., Brombin, A., Peterson, S., Postlethwait, J.H., Patton, E.E. (2022) Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Development (Cambridge, England). 149(10):

Lu, Y., Patton, E.E. (2022) Long-term non-invasive drug treatments in adult zebrafish that lead to melanoma drug resistance. Disease models & mechanisms. 15(5):

Brombin, A., Simpson, D.J., Travnickova, J., Brunsdon, H., Zeng, Z., Lu, Y., Young, A.I.J., Chandra, T., Patton, E.E. (2022) Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential. Cell Reports. 38:110234

He, S., Zimmerman, M.W., Layden, H.M., Berezovskaya, A., Etchin, J., Martel, M.W., Thurston, G., Jing, C.B., van Rooijen, E., Kaufman, C.K., Rodig, S.J., Zon, L.I., Patton, E.E., Mansour, M.R., Look, A.T. (2021) Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 40(38):5718-5729

Patton, E.E., Mueller, K.L., Adams, D.J., Anandasabapathy, N., Aplin, A.E., Bertolotto, C., Bosenberg, M., Ceol, C.J., Chi, P., Herlyn, M., Holmen, S.L., Karreth, F.A., Kaufman, C.K., Khan, S., Kobold, S., Leucci, E., Levy, C., Lombard, D.B., Lund, A.W., Marie, K.L., Marine, J.C., Marais, R., McMahon, M., Robles-Espinoza, C.D., Ronai, Z.A., Samuels, Y., Soengas, M.S., Villanueva, J., Weeraratna, A.T., White, R.M., Yeh, I., Zhu, J., Zon, L.I., Hurlbert, M.S., Merlino, G. (2021) Melanoma models for the next generation of therapies. Cancer Cell. 39(5):610-631

Dilshat, R., Fock, V., Kenny, C., Gerritsen, I., Lasseur, R.M.J., Travnickova, J., Eichhoff, O.M., Cerny, P., Möller, K., Sigurbjörnsdóttir, S., Kirty, K., Einarsdottir, B.Ó., Cheng, P.F., Levesque, M., Cornell, R.A., Patton, E.E., Larue, L., de Tayrac, M., Magnúsdóttir, E., Helga Ögmundsdóttir, M., Steingrimsson, E. (2021) MITF reprograms the extracellular matrix and focal adhesion in melanoma. eLIFE. 10:

Travnickova, J., Patton, E.E. (2020) Deciphering melanoma cell states and plasticity with zebrafish models. The Journal of investigative dermatology. 141(6):1389-1394

Banik, I., Cheng, P.F., Dooley, C.M., Travnickova, J., Merteroglu, M., Dummer, R., Patton, E.E., Busch-Nentwich, E.M., Levesque, M.P. (2020) NRAS^Q61K melanoma tumor formation is reduced by p38-MAPK14 activation in zebrafish models and NRAS-mutated human melanoma cells. Pigment cell & melanoma research. 34(2):150-162

Louphrasitthiphol, P., Siddaway, R., Loffreda, A., Pogenberg, V., Friedrichsen, H., Schepsky, A., Zeng, Z., Lu, M., Strub, T., Freter, R., Lisle, R., Suer, E., Thomas, B., Schuster-Böckler, B., Filippakopoulos, P., Middleton, M., Lu, X., Patton, E.E., Davidson, I., Lambert, J.P., Wilmanns, M., Steingrímsson, E., Mazza, D., Goding, C.R. (2020) Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution. Molecular Cell. 79:472-487.e10

Johansson, J.A., Marie, K.L., Lu, Y., Brombin, A., Santoriello, C., Zeng, Z., Zich, J., Gautier, P., von Kriegsheim, A., Brunsdon, H., Wheeler, A.P., Dreger, M., Houston, D.R., Dooley, C.M., Sims, A.H., Busch-Nentwich, E.M., Zon, L.I., Illingworth, R.S., Patton, E.E. (2020) PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Developmental Cell. 54(3):317-332.e9

Dambroise, E., Ktorza, I., Brombin, A., Abdessalem, G., Edouard, J., Luka, M., Fiedler, I., Binder, O., Pelle, O., Patton, E.E., Busse, B., Menager, M., Sohm, F., Legeai-Mallet, L. (2020) Fgfr3 is a positive regulator of osteoblast expansion and differentiation during zebrafish skull vault development. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 35(9):1782-1797

Travnickova, J., Wojciechowska, S., Khamseh, A., Gautier, P., Brown, D.V., Lefevre, T., Brombin, A., Ewing, A., Capper, A., Spitzer, M., Dilshat, R., Semple, C.A., Mathers, M.E., Lister, J.A., Steingrímsson, E., Voet, T., Ponting, C.P., Patton, E.E. (2019) Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease. Cancer research. 79(22):5769-5784

Patton, E.E., Tobin, D.M. (2019) Spotlight on zebrafish: the next wave of translational research. Disease models & mechanisms. 12(3)

Camargo-Sosa, K., Colanesi, S., Müller, J., Schulte-Merker, S., Stemple, D., Patton, E.E., Kelsh, R.N. (2019) Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish. PLoS Genetics. 15:e1007941

Zeng, Z., Lopez-Baez, J.C., Lleras-Forero, L., Brunsdon, H., Wyatt, C., Rybski, W., Hastie, N.D., Schulte-Merker, S., Patton, E.E. (2018) Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae. Bio-protocol. 8:e3100

Brunsdon, H., Patton, E.E. (2018) Fishing for ancestry. eLIFE. 7

Bouffard, S., Dambroise, E., Brombin, A., Lempereur, S., Hatin, I., Simion, M., Corre, R., Bourrat, F., Joly, J.S., Jamen, F. (2018) Fibrillarin is essential for S-phase progression and neuronal differentiation in zebrafish dorsal midbrain and retina. Developmental Biology. 437(1):1-16

Al-Olabi, L., Polubothu, S., Dowsett, K., Andrews, K.A., Stadnik, P., Joseph, A.P., Knox, R., Pittman, A., Clark, G., Baird, W., Bulstrode, N., Glover, M., Gordon, K., Hargrave, D., Huson, S.M., Jacques, T.S., James, G., Kondolf, H., Kangesu, L., Keppler-Noreuil, K.M., Khan, A., Lindhurst, M.J., Lipson, M., Mansour, S., O'Hara, J., Mahon, C., Mosica, A., Moss, C., Murthy, A., Ong, J., Parker, V.E., Rivière, J.B., Sapp, J.C., Sebire, N.J., Shah, R., Sivakumar, B., Thomas, A., Virasami, A., Waelchli, R., Zeng, Z., Biesecker, L.G., Barnacle, A., Topf, M., Semple, R.K., Patton, E.E., Kinsler, V.A. (2018) Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy. The Journal of Clinical Investigation. 128(4):1496-1508

Lopez-Baez, J.C., Simpson, D.J., LLeras Forero, L., Zeng, Z., Brunsdon, H., Salzano, A., Brombin, A., Wyatt, C., Rybski, W., Huitema, L.F.A., Dale, R.M., Kawakami, K., Englert, C., Chandra, T., Schulte-Merker, S., Hastie, N.D., Patton, E.E. (2018) Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.. eLIFE. 7

Scahill, C.M., Digby, Z., Sealy, I.M., Wojciechowska, S., White, R.J., Collins, J.E., Stemple, D.L., Bartke, T., Mathers, M.E., Patton, E.E., Busch-Nentwich, E.M. (2017) Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish. PLoS Genetics. 13:e1006959

Fraser, C., Dawson, J.C., Dowling, R., Houston, D.R., Weiss, J.T., Munro, A.F., Muir, M., Harrington, L., Webster, S.P., Frame, M.C., Brunton, V.G., Patton, E.E., Carragher, N.O., Unciti-Broceta, A. (2016) Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines that Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase. Journal of medicinal chemistry. 59(10):4697-4710

Thomas, A.C., Zeng, Z., Rivière, J.B., O'Shaughnessy, R., Al-Olabi, L., St-Onge, J., Atherton, D.J., Aubert, H., Bagazgoitia, L., Barbarot, S., Bourrat, E., Chiaverini, C., Chong, W.K., Duffourd, Y., Glover, M., Groesser, L., Hadj-Rabia, S., Hamm, H., Happle, R., Mushtaq, I., Lacour, J.P., Waelchli, R., Wobser, M., Vabres, P., Patton, E.E., Kinsler, V.A. (2016) Mosaic activating mutations in GNA11 and GNAQ are associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis. The Journal of investigative dermatology. 136(4):770-8

Macdonald, N.P., Zhu, F., Hall, C.J., Reboud, J., Crosier, P.S., Patton, E.E., Wlodkowic, D., Cooper, J.M. (2016) Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays. Lab on a Chip. 16(2):291-7

van der Weyden, L., Patton, E.E., Wood, G.A., Foote, A., Brenn, T., Arends, M.J., Adams, D.J. (2016) Cross-species models of human melanoma. The Journal of pathology. 238(2):152-65

Wojciechowska, S., van Rooijen, E., Ceol, C., Patton, E.E., White, R.M. (2016) Generation and analysis of zebrafish melanoma models. Methods in cell biology. 134:531-49

Wojciechowska, S., Zeng, Z., Lister, J.A., Ceol, C.J., Patton, E.E. (2016) Melanoma Regression and Recurrence in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1451:143-53

Lundegaard, P.R., Anastasaki, C., Grant, N.J., Sillito, R.R., Zich, J., Zeng, Z., Paranthaman, K., Larsen, A.P., Armstrong, J.D., Porteous, D.J., Patton, E.E. (2015) MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish. Chemistry & Biology. 22(10):1335-46

Zeng, Z., Johnson, S.L., Lister, J.A., Patton, E.E. (2015) Temperature-sensitive splicing of mitfa by an intron mutation in zebrafish. Pigment cell & melanoma research. 28(2):229-32

Mort, R.L., Jackson, I.J., Patton, E.E. (2015) The melanocyte lineage in development and disease. Development (Cambridge, England). 142:620-632

Patton, E.E., Dhillon, P., Amatruda, J.F., Ramakrishnan, L. (2014) Spotlight on Zebrafish: Translational Impact. Disease models & mechanisms. 7:731-733

Weiss, J.T., Dawson, J.C., Fraser, C., Rybski, W., Torres-Sanchez, C., Bradley, M., Patton, E.E., Carragher, N.O., Unciti-Broceta, A. (2014) Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine. Journal of medicinal chemistry. 57(12):5395-404

Lister, J.A., Capper, A., Zeng, Z., Mathers, M.E., Richardson, J., Paranthaman, K., Jackson, I.J., and Patton, E.E. (2014) A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo. The Journal of investigative dermatology. 134(1):133-40

Weiss, J.T., Dawson, J.C., Macleod, K.G., Rybski, W., Fraser, C., Torres-Sánchez, C., Patton, E.E., Bradley, M., Carragher, N.O., and Unciti-Broceta, A. (2014) Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach. Nature communications. 5:3277

Recher, G., Jouralet, J., Brombin, A., Heuzé, A., Mugniery, E., Hermel, J.M., Desnoulez, S., Savy, T., Herbomel, P., Bourrat, F., Peyriéras, N., Jamen, F., and Joly, J.S. (2013) Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Development (Cambridge, England). 140(24):4860-9

Longman, D., Hug, N., Keith, M., Anastasaki, C., Patton, E.E., Grimes, G., and Cáceres, J.F. (2013) DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic acids research. 41(17):8319-31

Reimer, M.M., Norris, A., Ohnmacht, J., Patani, R., Zhong, Z., Dias, T.B., Kuscha, V., Scott, A.L., Chen, Y.C., Rozov, S., Frazer, S.L., Wyatt, C., Higashijima, S., Patton, E.E., Panula, P., Chandran, S., Becker, T., and Becker, C.G. (2013) Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration. Developmental Cell. 25(5):478-491

Yen, J., White, R.M., Wedge, D.C., Van Loo, P., de Ridder, J., Capper, A., Richardson, J., Jones, D., Raine, K., Watson, I.R., Wu, C.J., Cheng, J., Martincorena, I., Nik-Zainal, S., Mudie, L., Moreau, Y., Marshall, J., Ramakrishna, M., Tarpey, P., Shlien, A., Whitmore, I., Gamble, S., Latimer, C., Langdon, E., Kaufman, C., Dovey, M., Taylor, A., Menzies, A., McLaren, S., O Meara, S., Butler, A., Teague, J., Lister, J., Chin, L., Campbell, P., Adams, D.J., Zon, L.I., Patton, E.E., Stemple, D.L., and Futreal, P.A. (2013) The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome biology. 14(10):R113

Patton, E.E. (2012) Live imaging in zebrafish reveals neu(trophil) insight into the metastatic niche. The Journal of pathology. 227(4):381-384

Zhou, L., Ishizaki, H., Spitzer, M., Taylor, K.L., Temperley, N.D., Johnson, S.L., Brear, P., Gautier, P., Zeng, Z., Mitchell, A., Narayan, V., McNeil, E.M., Melton, D.W., Smith, T.K., Tyers, M., Westwood, N.J., and Patton, E.E. (2012) ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species. Chemistry & Biology. 19(7):883-892

Anastasaki, C., Rauen, K.A., and Patton, E.E. (2012) Continual and partial MEK inhibition ameliorates cardio-facio-cutaneous phenotypes in zebrafish. Disease models & mechanisms. 5(4):546-552

Colanesi, S., Taylor, K.L., Temperley, N.D., Lundegaard, P.R., Liu, D., North, T.E., Ishizaki, H., Kelsh, R.N., and Patton, E.E. (2012) Small molecule screening identifies targetable zebrafish pigmentation pathways. Pigment cell & melanoma research. 25(2):131-143

Taylor, K.L., Lister, J.A., Zeng, Z., Ishizaki, H., Anderson, C., Kelsh, R.N., Jackson, I.J., and Patton, E.E. (2011) Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf. Development (Cambridge, England). 138(16):3579-89

Shu, X., Zeng, Z., Gautier, P., Lennon, A., Gakovic, M., Cheetham, M.E., Patton, E.E., and Wright, A.F. (2011) Knock-down of the Zebrafish Orthologue of the Retinitis Pigmentosa 2 (RP2) Gene Results in Retinal Degeneration. Investigative ophthalmology & visual science. 52(6):2960-6

Anastasaki, C., Longman, D., Capper, A., Patton, E.E., and Cáceres, J.F. (2011) Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic acids research. 39(9):3686-3694

Donaldson, L.R., Wallace, S., Haigh, D., Patton, E.E., and Hulme, A.N. (2011) Rapid synthesis and zebrafish evaluation of a phenanthridine-based small molecule library. Organic & biomolecular chemistry. 9(7):2233-9

Richardson, J., Zeng, Z., Ceol, C., Mione, M., Jackson, I.J., and Patton, E.E. (2011) A zebrafish model for nevus regeneration. Pigment cell & melanoma research. 24(2):378-381

Patton, E.E., Mathers, M.E., and Schartl, M. (2011) Generating and analyzing fish models of melanoma. Methods in cell biology. 105:339-366

Ishizaki, H., Spitzer, M., Wildenhain, J., Anastasaki, C., Zeng, Z., Dolma, S., Shaw, M., Madsen, E., Gitlin, J., Marais, R., Tyers, M., and Patton, E.E. (2010) Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation. Disease models & mechanisms. 3(9-10):639-651

Taylor, K.L., Grant, N.J., Temperley, N.D., and Patton, E.E. (2010) Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads. Cell communication and signaling : CCS. 8:11

Patton, E.E., Mitchell, D.L., and Nairn, R.S. (2010) Genetic and Environmental Melanoma Models in Fish. Pigment cell & melanoma research. 23(3):314-337

Grabher, C., Patton, E.E., and Strähle, U. (2010) Sharing Chemical Libraries Within the European Zebrafish Community. Zebrafish. 7(1):83

Shu, X., Zeng, Z., Gautier, P., Lennon, A., Gakovic, M., Patton, E., and Wright, A. (2010) Zebrafish Rpgr is required for normal retinal development and plays a role in dynein-based retrograde transport processes. Human molecular genetics. 19(4):657-670

Poulton, L.D., Nolan, K.F., Anastasaki, C., Waldmann, H., and Patton, E.E. (2010) A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development. The International journal of developmental biology. 54(5):815-825

Zeng, Z., Richardson, J., Verduzco, D., Mitchell, D.L., and Patton, E.E. (2009) Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin. Zebrafish. 6(4):405-415

Anastasaki, C., Estep, A.L., Marais, R., Rauen, K.A., and Patton, E.E. (2009) Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors. Human molecular genetics. 18(14):2543-2554

Dovey, M., Patton, E.E., Bowman, T., North, T., Goessling, W., Zhou, Y., and Zon, L.I. (2009) Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. Molecular and cellular biology. 29(13):3746-3753

Richardson, J., Lundegaard, P.R., Reynolds, N.L., Dorin, J.R., Porteous, D.J., Jackson, I.J., and Patton, E.E. (2008) mc1r Pathway regulation of zebrafish melanosome dispersion. Zebrafish. 5(4):289-295

Amatruda, J.F., and Patton, E.E. (2008) Chapter 1 genetic models of cancer in zebrafish. International review of cell and molecular biology. 271:1-34

Grzmil, M., Whiting, D., Maule, J., Anastasaki, C., Amatruda, J.F., Kelsh, R.N., Norbury, C.J., and Patton, E.E. (2007) The INT6 Cancer Gene and MEK Signaling Pathways Converge during Zebrafish Development. PLoS One. 2(9):e959

Patton, E.E., Widlund, H.R., Kutok, J.L., Kopani, K.R., Amatruda, J.F., Murphey, R.D., Berghmans, S., Mayhall, E.A., Traver, D., Fletcher, C.D., Aster, J.C., Granter, S.R., Look, A.T., Lee, C., Fisher, D.E., and Zon, L.I. (2005) BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma. Current biology : CB. 15(3):249-254

Patton, E.E. and Zon, L.I. (2005) Taking Human Cancer Genes to the Fish: A Transgenic Model of Melanoma in Zebrafish. Zebrafish. 1(4):363-368

Traver, D., Herbomel, P., Patton, E.E., Murphey, R.D., Yoder, J.A., Litman, G.W., Catic, A., Amemiya, C.T., Zon, L.I., and Trede, N.S. (2003) The zebrafish as a model organism to study development of the immune system. Advances in immunology. 81:253-330

Patton, E.E. and Zon, L.I. (2001) The art and design of genetic screens: zebrafish. Nature reviews. Genetics. 2(12):956-966