ZFIN ID: ZDB-LAB-060807-1
Song Lab
PI/Director: Song, Houyan
Zhong, Peter Tao
Contact Person: Song, Houyan
Email: hysong@shmu.edu.cn
Address: Department of Molecular Genetics, Shanghai Medical School Key Laboratory of Molecular Medicine, Ministry of Education Fudan University 138 Yi Xueyuan Road Shanghai, 200032 CHINA
Country: China
Phone: +86 21 5423 7739
Fax: +86 21 6403 3738
Line Designation: fdu

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We are particularly interested in the roles of BMP2 and MEF2A signaling pathways in zebrafish cardiovascular system and somite development. We try to get new insights into the prevention and treatment of related human diseases.

The research on environmental toxicology, particularly the effects of Endocrine Disrupting Chemicals on zebrafish development, is going on at our lab. We hope these investigations will provide new clues to the detection and management of environmental pollutants.

Dong, Yongxin Graduate Student Gao, Guanwen Graduate Student Qian, Linxi Graduate Student
Wang, Yuexiang Graduate Student Jiang, Qiu Technical Staff

Qiu, Y., Sun, S., Yu, X., Zhou, J., Cai, W., Qian, L. (2020) Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1865(6):158663
Sun, S., Liu, Z., Li, X., Jia, J., Zhang, G., Yang, C., Jiang, Q., Zou, Y. (2020) Characterization of a nap1l1 transgenic reporter in zebrafish. Gene. 735:144388
Sun, S., Li, X., Liu, Z., Zhang, G., Yang, C., Jiang, Q., Zou, Y. (2019) Expression of nucleosome assembly protein 1 like genes in zebrafish embryos. Gene expression patterns : GEP. 35:119076
Zhang, R., He, J., Wang, X., Pan, W., Cao, Y., Zu, Y., Jiang, Q., Du, J., Zhong, T.P. (2018) Report of the Fifth Zebrafish Research Conference of China. Zebrafish. 16(1):128-134
Li, Y., Sun, S., Ding, Z., Yang, C., Zhang, G., Jiang, Q., Zou, Y. (2018) Temporal and spatial expression of fgfbp genes in zebrafish. Gene. 659:128-136
Wang, X., Ling, C.C., Li, L., Qin, Y., Qi, J., Liu, X., You, B., Shi, Y., Zhang, J., Jiang, Q., Xu, H., Sun, C., You, Y., Chai, R., Liu, D. (2016) MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Cardiovascular research. 110(1):140-50
Hu, J., Sun, S., Guo, M., Song, H. (2014) Use of antagonists and morpholinos in loss-of-function analyses: estrogen receptor ESR2a mediates the effects of 17alpha-ethinylestradiol on primordial germ cell distribution in zebrafish. Reproductive Biology and Endocrinolgy. 12:40
Wang, W., Zhang, L.F., Gui, Y.H., Hu, J.Y., and Song, H.Y. (2013) Tbx1 regulates the development of zebrafish neural crest cells by retinoic acid signaling. Chinese Medical Journal. 126(23):4583-4584
Jiang, Q., Lagos-Quintana, M., Liu, D., Shi, Y., Helker, C., Herzog, W., and le Noble, F. (2013) miR-30a Regulates Endothelial Tip Cell Formation and Arteriolar Branching. Hypertension (Dallas, Tex. : 1979). 62(3):592-8
Bao, Y., Li, Y., Jiang, Q., Zhao, L., Xue, T., Hu, B., and Sun, B. (2013) Methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system. International journal of medical microbiology : IJMM. 303(4):190-200
Wang, W., Zhang, L.F., Gui, Y.H., and Song, H.Y. (2013) Retinol dehydrogenase, RDH1l, is essential for the heart development and cardiac performance in zebrafish. Chinese Medical Journal. 126(4):722-728
Hu, J., Sun, S., Jiang, Q., Sun, S., Wang, W., Gui, Y., and Song, H. (2013) Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). International journal of biological sciences. 9(3):267-278
Sun, S., Gui, Y., Jiang, Q., and Song, H. (2011) Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish. Acta biochimica et biophysica Sinica. 43(12):957-969
Jiang, Q., Liu, D., Sun, S., Hu, J., Tan, L., Wang, Y., Gui, Y., Yu, M., and Song, H. (2010) Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis. Fish physiology and biochemistry. 36(4):945-951
Liang, J., Gui, Y., Wang, W., Gao, S., Li, J., and Song, H. (2010) Elevated glucose induces congenital heart defects by altering the expression of tbx5, tbx20, and has2 in developing zebrafish embryos. Birth defects research. Part A, Clinical and molecular teratology. 88(6):480-486
Zhang, L.F., Gui, Y.H., Wang, Y.X., Jiang, Q., and Song, H.Y. (2010) Effect of Tbx1 knock-down on cardiac performance in zebrafish. Chinese Medical Journal. 123(9):1182-1189
Chen, H., Hu, J., Yang, J., Wang, Y., Xu, H., Jiang, Q., Gong, Y., Gu, Y., and Song, H. (2010) Generation of a fluorescent transgenic zebrafish for detection of environmental estrogens. Aquatic toxicology (Amsterdam, Netherlands). 96(1):53-61
Jiang, Q., Liu, D., Gong, Y., Wang, Y., Sun, S., Gui, Y., and Song, H. (2009) yap is required for the development of brain, eyes, and neural crest in zebrafish. Biochemical and Biophysical Research Communications. 384(1):114-119
Sun, S., Gui, Y., Wang, Y., Qian, L., Liu, X., Jiang, Q., and Song, H. (2009) Effects of methotrexate on the developments of heart and vessel in zebrafish. Acta biochimica et biophysica Sinica. 41(1):86-96
Xu, H., Yang, J., Wang, Y., Jiang, Q., Chen, H., and Song, H. (2008) Exposure to 17α-ethynylestradiol impairs reproductive functions of both male and female zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 88(1):1-8
Sun, S.N., Gui, Y.H., Wang, Y.X., Qian, L.X., Jiang, Q., Liu, D., and Song, H.Y. (2007) Effect of dihydrofolate reductase gene knock-down on the expression of heart and neural crest derivatives expressed transcript 2 in zebrafish cardiac development. Chinese Medical Journal. 120(13):1166-1171
Wang, Y.X., Qian, L.X., Liu, D., Yao, L.L., Jiang, Q., Yu, Z., Gui, Y.H., Zhong, T.P., and Song, H.Y. (2007) Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility. Cardiovascular research. 74(2):290-303
Wang, Y., Qian, L., Dong, Y., Jiang, Q., Gui, Y., Zhong, T.P., and Song, H. (2006) Myocyte-specific enhancer factor 2A is essential for zebrafish posterior somite development. Mechanisms of Development. 123(10):783-791
Zhang, L., Zhong, T., Wang, Y., Jiang, Q., Song, H., and Gui, Y. (2006) TBX1, a DiGeorge syndrome candidate gene, is inhibited by retinoic acid. The International journal of developmental biology. 50(1):55-61
Qian, L., Wang, Y., Jiang, Q., Zhong, T., and Song, H. (2005) Ethanol disrupts the formation of hypochord and dorsal aorta during the development of embryonic zebrafish. Science in China. Series C, Life sciences. 48(6):608-615
Wang, Y.X., Qian, L.X., Yu, Z., Jiang, Q., Dong, Y.X., Liu, X.F., Xin-Ying, Y., Zhong, T.P., and Song, H.Y. (2005) Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility. FEBS letters. 579(21):4843-4850
Wang, Y., Zhong, T., Qian, L., Dong, Y., Jiang, Q., Tan, L., and Song, H. (2005) Wortmannin induces zebrafish cardia bifida through a mechanism independent of phosphoinositide 3-kinase and myosin light chain kinase. Biochemical and Biophysical Research Communications. 331(1):303-308