ZFIN Lab: Jin Lab

ZFIN ID: ZDB-LAB-060628-1

Jin Lab

PI/Director:	Jin, Suk-Won
Contact Person:	Jin, Suk-Won
Email:	suk-won.jin@yale.edu
URL:
Address:	Suk-Won Jin, Ph.D. Assistant Professor Dept. of Internal Medicine Section of Cardiovascular Medicine Yale University School of Medicine New Haven, CT, 06511
Country:	United States
Phone:	203-737-2866
Fax:
Line Designation:	nc

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 9 genomic features

STATEMENT OF RESEARCH INTERESTS

The main scientific interest of the laboratory is to understand how endothelial cells are specified and how these cells form vascular tubes.

LAB MEMBERS

Cardona-Costa, Jose Post-Doc	Dunworth, William Post-Doc	Schmitt, Chris Graduate Student
Woolls, Melissa Graduate Student	Kang, Hyeseon Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Ka, J., Jin, S.W. (2021) Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases. Journal of lipid and atherosclerosis. 10:42-56

Ka, J., Kim, J.D., Pak, B., Han, O., Choi, W., Kim, H., Jin, S.W. (2020) Bone Morphogenetic Protein Signaling Restricts Proximodistal Extension of the Ventral Fin Fold. Frontiers in cell and developmental biology. 8:603306

Pak, B., Schmitt, C.E., Oh, S., Kim, J.D., Choi, W., Han, O., Kim, M., Kim, M.J., Ham, H.J., Kim, S., Huh, T.L., Kim, J.I., Jin, S.W. (2020) Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish. Biochemical and Biophysical Research Communications. 534:359-366

Pak, B., Schmitt, C.E., Choi, W., Kim, J.D., Han, O., Alsiö, J., Jung, D.W., Williams, D.R., Coppieters, W., Stainier, D.Y.R., Jin, S.W. (2020) Analyses of Avascular Mutants Reveal Unique Transcriptomic Signature of Non-conventional Endothelial Cells. Frontiers in cell and developmental biology. 8:589717

Kim, A.R., Kim, S.W., Lee, B.W., Kim, K.H., Kim, W.H., Seok, H., Lee, J.H., Um, J., Yim, S.H., Ahn, Y., Jin, S.W., Jung, D.W., Oh, W.K., Williams, D.R. (2020) Screening ginseng saponins in progenitor cells identifies 20(R)-ginsenoside Rh₂ as an enhancer of skeletal and cardiac muscle regeneration. Scientific Reports. 10:4967

Karthik, S., Djukic, T., Kim, J.D., Zuber, B., Makanya, A., Odriozola, A., Hlushchuk, R., Filipovic, N., Jin, S.W., Djonov, V. (2019) Publisher Correction: Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development. Scientific Reports. 9:4152

Karthik, S., Djukic, T., Kim, J.D., Zuber, B., Makanya, A., Odriozola, A., Hlushchuk, R., Filipovic, N., Jin, S.W., Djonov, V. (2018) Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development. Scientific Reports. 8:9840

Reischauer, S., Stone, O.A., Villasenor, A., Chi, N., Jin, S.W., Martin, M., Lee, M.T., Fukuda, N., Marass, M., Witty, A., Fiddes, I., Kuo, T., Chung, W.S., Salek, S., Lerrigo, R., Alsiö, J., Luo, S., Tworus, D., Augustine, S.M., Mucenieks, S., Nystedt, B., Giraldez, A.J., Schroth, G.P., Andersson, O., Stainier, D.Y.R. (2018) Corrigendum: Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 555:543

Peneyra, S.M., Cardona-Costa, J., White, J., Whipps, C.M., Riedel, E.R., Lipman, N.S., Lieggi, C. (2017) Transmission of Pseudoloma neurophilia in Laboratory Zebrafish (Danio rerio) When Using Mass Spawning Chambers and Recommendations for Chamber Disinfection. Zebrafish. 15(1):63-72

Hwangbo, C., Lee, H.W., Kang, H., Ju, H., Wiley, D.S., Papangeli, I., Han, J., Kim, J.D., Dunworth, W.P., Hu, X., Lee, S., El-Hely, O., Sofer, A., Pak, B., Peterson, L., Comhair, S., Hwang, E.M., Park, J.Y., Thomas, J.L., Bautch, V.L., Erzurum, S.C., Chun, H.J., Jin, S.W. (2017) Modulation of Endothelial BMPR2 Activity by VEGFR3 in Pulmonary Arterial Hypertension. Circulation. 135(23):2288-2298

Mouillesseaux, K.P., Wiley, D.S., Saunders, L.M., Wylie, L.A., Kushner, E.J., Chong, D.C., Citrin, K.M., Barber, A.T., Park, Y., Kim, J.D., Samsa, L.A., Kim, J., Liu, J., Jin, S.W., Bautch, V.L. (2016) Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6.. Nature communications. 7:13247

Kim, Y.S., Jeong, H.Y., Kim, A.R., Kim, W.H., Cho, H., Um, J., Seo, Y., Kang, W.S., Jin, S.W., Kim, M.C., Kim, Y.C., Jung, D.W., Williams, D.R., Ahn, Y. (2016) Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment. Scientific Reports. 6:30726

Reischauer, S., Stone, O.A., Villasenor, A., Chi, N., Jin, S.W., Martin, M., Lee, M.T., Fukuda, N., Marass, M., Witty, A., Fiddes, I., Kuo, T., Chung, W.S., Salek, S., Lerrigo, R., Alsiö, J., Luo, S., Tworus, D., Augustine, S.M., Mucenieks, S., Nystedt, B., Giraldez, A.J., Schroth, G.P., Andersson, O., Stainier, D.Y. (2016) Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 535:294-8

Cha, J.J., Park, Y., Yun, J., Kim, H.W., Park, C.J., Kang, G., Jung, M., Pak, B., Jin, S.W., Lee, J.H. (2016) Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers. BioMed Research International. 2016:8484217

So, J.H., Kim, J.D., Yoo, K.W., Kim, H.T., Jung, S.H., Choi, J.H., Lee, M.S., Jin, S.W., Kim, C.H. (2014) FIH-1, a Novel Interactor of Mindbomb, Functions as an Essential Anti-Angiogenic Factor during Zebrafish Vascular Development. PLoS One. 9:e109517

Kim, J.D., Lee, H.W., Jin, S.W. (2014) Diversity Is in My Veins: Role of Bone Morphogenetic Protein Signaling During Venous Morphogenesis in Zebrafish Illustrates the Heterogeneity Within Endothelial Cells. Arterioscler. Thromb. Vasc. Biol.. 34(9):1838-45

Kim, J.D., Jin, S.W. (2014) A Tale of Two Models: Mouse and Zebrafish as Complementary Models for Lymphatic Studies. Molecules and cells. 37(7):503-10

Sakurai, T., Woolls, M.J., Jin, S.W., Murakami, M., Simons, M. (2014) Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PLoS One. 9:e90736

Kim, J.D., Kang, Y., Kim, J., Papangeli, I., Kang, H., Wu, J., Park, H., Nadelmann, E., Rockson, S.G., Chun, H.J., and Jin, S.W. (2014) Essential role of apelin signaling during lymphatic development in zebrafish. Arterioscler. Thromb. Vasc. Biol.. 34(2):338-345

Dunworth, W.P., Cardona-Costa, J., Cagavi, E., Kim, J.D., Fischer, J.C., Meadows, S., Wang, Y., Cleaver, O., Qyang, Y., Ober, E.A., and Jin, S.W. (2014) Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos. Circulation research. 114(1):56-66

Nie, L., Guo, X., Esmailzadeh, L., Zhang, J., Asadi, A., Collinge, M., Li, X., Kim, J.D., Woolls, M., Jin, S.W., Dubrac, A., Eichmann, A., Simons, M., Bender, J.R., and Sadeghi, M.M. (2013) Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J. Clin. Invest.. 123(12):5082-97

Schmitt, C.E., Woolls, M.J., and Jin, S.W. (2013) Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish. Molecules and cells. 35(2):166-172

Kim, S.H., Schmitt, C.E., Woolls, M.J., Holland, M.B., Kim, J.D., and Jin, S.W. (2013) Vascular Endothelial Growth Factor Signaling Regulates the Segregation of Artery and Vein via ERK Activity during Vascular Development. Biochemical and Biophysical Research Communications. 430(4):1212-1216

Schmitt, C.E. (2013) Identification of Novel Transcription Factors Regulating Recovery of the Endothelial Lineage in Avascular Mutants. Ph.D. Thesis.

Woolls, M.J. (2013) Hemogenic Endothelium within the Zebrafish Caudal Hematopoietic Tissue illustrates the Common Ties of the Vascular and Hematopoietic Systems. Ph.D. Thesis.

Pi, X., Schmitt, C.E., Xie, L., Portbury, A.L., Wu, Y., Lockyer, P., Dyer, L.A., Moser, M., Bu, G., Flynn, E.J., Jin, S.W., and Patterson, C. (2012) An LRP1-Dependent Endocytic Mechanism Governs the Signaling Output of the BMP System in Endothelial Cells and in Angiogenesis. Circulation research. 111(5):564-574

Kim, J.D., Kang, H., Larrivée, B., Lee, M.Y., Mettlen, M., Schmid, S.L., Roman, B.L., Qyang, Y., Eichmann, A., and Jin, S.W. (2012) Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Developmental Cell. 23(2):441-448

Cardona-Costa, J., Pérez-Camps, M., and García-Ximénez, F. (2012) Somatic cells derived from haploid larvae are feasible as donors for nuclear transplant in zebrafish. Preliminary results. Zygote (Cambridge, England). 20(3):277-280

Schmitt, C.E., Holland, M.B., and Jin, S.W. (2012) Visualizing vascular networks in zebrafish: an introduction to microangiography. Methods in molecular biology (Clifton, N.J.). 843:59-67

Wiley, D.M., Kim, J.D., Hao, J., Hong, C.C., Bautch, V.L., and Jin, S.W. (2011) Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nature cell biology. 13(6):686-92

Francisco-Simão, M., Cardona-Costa, J., Pérez-Camps, M., and García-Ximénez, F. (2011) Ultraviolet radiation and handling medium osmolarity affect chimaerism success in zebrafish. Zygote (Cambridge, England). 19(1):67-70

Cardona-Costa, J., Pérez-Camps, M., and García-Ximénez, F. (2011) Electroactivation of zebrafish (Danio rerio) eggs. Spanish journal of agricultural research. 9(1):59-65

Francisco-Simão, M., Cardona-Costa, J., Perez Camps, M., and García-Ximénez, F. (2010) Ultraviolet Radiation Dose to be Applied in Recipient Zebrafish Embryos for Germ-line Chimaerism is Strain Dependent. Reproduction in domestic animals = Zuchthygiene. 45(6):1098-1103

Pérez-Camps, M., Cardona-Costa, J., and García-Ximénez, F. (2010) Transplantation of Adult Fibroblast Nuclei into the Central Region of Metaphase II Eggs Resulted in Mid-Blastula Transition Embryos. Zebrafish. 7(2):215-218

Cardona-Costa, J., Francisco-Simão, M., Pérez-Camps, M., and García-Ximénez, F. (2010) Micromanipulation medium osmolarity compromises zebrafish (Danio rerio) embryo and cell survival in chimaerism experiments. Zygote (Cambridge, England). 18(2):155-158

Pérez-Camps, M., Cardona-Costa, J., Francisco-Simao, M., and García-Ximénez, F. (2010) Definition of three somatic adult cell nuclear transplant methods in zebrafish (Danio rerio): before, during and after egg activation by sperm fertilization. Zygote (Cambridge, England). 18(1):33-39

Cardona-Costa, J., Francisco-Simão, M., and García-Ximénez, F. (2009) Can vitrified zebrafish blastomeres be used to obtain germ-line chimaeras?. Cryo letters. 30(6):422-428

Lee, C.Y., Vogeli, K.M., Kim, S.H., Chong, S.W., Jiang, Y.J., Stainier, D.Y., and Jin, S.W. (2009) Notch Signaling Functions as a Cell-Fate Switch between the Endothelial and Hematopoietic Lineages. Current biology : CB. 19(19):1616-1622

Bono-Mestre, C., Cardona-Costa, J., and García-Ximenez, F. (2009) Effects on cell viability of three zebrafish testicular cell or tissue cryopreservation methods. Cryo letters. 30(2):148-152

Cardona-Costa, J., Pérez-Camps, M., García-Ximénez, F., and Espinós, F.J. (2009) Effect of Gametes Aging on Their Activation and Fertilizability in Zebrafish (Danio rerio). Zebrafish. 6(1):93-95

Osborne, N., Brand-Arzamendi, K., Ober, E.A., Jin, S.W., Verkade, H., Holtzman, N.G., Yelon, D., and Stainier, D.Y. (2008) The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Current biology : CB. 18(23):1882-1888

Pérez-Camps, M., Francisco-Simão, M., Cardona-Costa, J., and García-Ximénez, F. (2008) Evaluation of presumptive caudal fin blastema cells as candidate donors in intrasecies zebrafish (Danio rerio) chimaeras. Spanish journal of agricultural research. 6(4):610-614

Cardona-Costa, J., and Garcia-Ximenez, F. (2007) Vitrification of zebrafish embryo blastomeres in microvolumes. Cryo letters. 28(4):303-310

Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y. (2007) A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Developmental Biology. 307(1):29-42

Scott, I.C., Masri, B., D'Amico, L.A., Jin, S.W., Jungblut, B., Wehman, A.M., Baier, H., Audigier, Y., and Stainier, D.Y. (2007) The G protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Developmental Cell. 12(3):403-413

Vogeli, K.M., Jin, S.W., Martin, G.R., and Stainier, D.Y. (2006) A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula. Nature. 443(7109):337-339

Cardona-Costa, J., Roig, J., Perez-Camps, M., and Garcia-Ximenez, F. (2006) Vitrification of caudal fin explants from zebrafish adult specimens. Cryo letters. 27(5):329-332

Jin, S.W., Beis, D., Mitchell, T., Chen, J.N., Stainier, D.Y. (2005) Cellular and molecular analyses of vascular tube and lumen formation in zebrafish. Development (Cambridge, England). 132(23):5199-5209

Beis, D., Bartman, T., Jin, S.W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.N., Stainier, D.Y., and Jungblut, B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (Cambridge, England). 132(18):4193-4204

Bree, R.T., McLoughlin, S., Jin, S.W., McMeel, O.M., Stainier, D.Y., Grealy, M., and Byrnes, L. (2005) nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafish. Biochemical and Biophysical Research Communications. 333(3):722-728

Qian, F., Zhen, F., Ong, C., Jin, S.W., Meng Soo, H., Stainier, D.Y., Lin, S., Peng, J., and Wen, Z. (2005) Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(3):1163-1172

Parker, L.H., Schmidt, M., Jin, S.W., Gray, A.M., Beis, D., Pham, T., Frantz, G., Palmieri, S., Hillan, K., Stainier, D.Y., De Sauvage, F.J., Ye, W. (2004) The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature. 425(6984):754-758

Ober, E.A., Olofsson, B., Makinen, T., Jin, S.W., Shoji, W., Koh, G.Y., Alitalo, K., and Stainier, D.Y. (2004) Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. EMBO reports. 5(1):78-84