ZFIN Lab: Center for Bioinformatics

ZFIN ID: ZDB-LAB-050727-1

ZFIN ID: ZDB-LAB-050727-1

Center for Bioinformatics

PI/Director:	Wong, Stephen T.C.
Co-PI / Senior Researcher:	Zhu, Jinmin
Contact Person:	Liu, Tianming
Email:	tliu@bwh.harvard.edu
URL:	http://neuroinformatics.harvard.edu
Address:	Harvard Center for Neurodegeneration and Repair Harvard Medical School 1249 Boylston Street 3rd floor Boston MA 02215
Country:	United States
Phone:	617-525-6241
Fax:
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Our lab is working to fill the gap between the explosion of zebrafish image data and the lack of robust quantitative analysis tools by developing zebrafish-specific image analysis algorithms and integrating them into a software package, called the Zfig: Zebrafish image quantitator. The Zfiq: image informatics platform would be designed to be applicable from small scales of biological studies to high throughput screens.

LAB MEMBERS

Liu, Tianming Post-Doc

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Wu, T., Lu, J., Lu, Y., Liu, T., and Yang, J. (2013) Embryo zebrafish segmentation using an improved hybrid method. Journal of microscopy. 250(1):68-75

Lu, Y., Lu, J., Liu, T., and Yang, J. (2011) Automated gene oscillation phase classification for zebrafish presomitic mesoderm cells. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 79(9):727-35

Zhao, H., Tang, C., Cui, K., Ang, B.T., and Wong, S.T. (2009) A screening platform for glioma growth and invasion using bioluminescence imaging. Journal of neurosurgery. 111(2):238-246

Zhao, H., Cui, K., Xia, W., and Wong, S.T.C. (2009) A new platform using bioluminescence imaging and zebrafish xenograft. Application in [gamma]-secretase inhibitors affect tumorigenesis. Texas and Southern Plains Zebrafish Meeting.

Liu, T., Nie, J., Li, G., Guo, L., and Wong, S.T. (2008) ZFIQ: a software package for zebrafish biology. Bioinformatics (Oxford, England). 24(3):438-439

Liu, T., Li, G., Nie, J., Tarokh, A., Zhou, X., Guo, L., Malicki, J., Xia, W., and Wong, S.T. (2008) An Automated Method for Cell Detection in Zebrafish. Neuroinformatics. 6(1):5-21

Li, G., Liu, T., Nie, J., Guo, L., Malicki, J., Mara, A., Holley, S.A., Xia, W., and Wong, S.T. (2007) Detection of blob objects in microscopic zebrafish images based on gradient vector diffusion. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 71(10):835-845

Liu, T., Lu, J., Wang, Y., Campbell, W.A., Huang, L., Zhu, J., Xia, W., and Wong, S.T.C. (2006) Computerized image analysis for quantitative neuronal phenotyping in zebrafish. Journal of Neuroscience Methods. 153(2):190-202

Campbell, W.A., Yang, H., Zetterberg, H., Baulac, S., Sears, J.A., Liu, T., Wong, S.T., Zhong, T.P., and Xia, W. (2006) Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. Journal of neurochemistry. 96(5):1423-1440